Antifungals for Topical Use

Antifungals for Topical Use
Accession Number
Not Available
ATC Classification
DrugDrug Description
TolnaftateAn antifungal agent used to treat various skin infections caused by fungi.
NaftifineAn antifungal agent used to treat infections of the Tinea, Trichophyton, and Epidermophyton species.
HaloproginUsed to treat fungal (Tinea) skin infections such as athlete's foot, jock itch, ringworm, and tinea versicolor.
ChlorphenesinA phenol ether used to treat painful muscular conditions.
TerbinafineAn allylamine antifungal used to treat dermatophyte infections of toenails and fingernails as well as other fungal skin infections.
Selenium SulfideAn antifungal used to treat dandruff, seborrheic dermatitis of the scalp, and tinea capitis.
TioconazoleAn imidazole antifungal used to treat vulvovaginal candidiasis.
ButenafineA topical antifungal used to treat tinea versicolor, tinea pedis, tinea cruris, and tinea corporis.
MiconazoleAn azole antifungal with broad-spectrum activity used to treat fungal infections affecting the vagina, mouth and skin, including candidiasis.
CiclopiroxA broad-spectrum topical antifungal agent used to treat mild to moderate onychomycosis of fingernails and toenails in immunocompetent patients.
BifonazoleUsed for the treatment of various topical fungal infections, including athlete's foot (tinea pedis).
SulconazoleA topical antifungal agent used for the treatment of tinea cruris, tinea corporis, and tinea versicolor caused by susceptible fungal strains.
LuliconazoleA topical antifungal agent used to treat fungal infections.
EfinaconazoleAn antifungal agent used to treat onychomycosis, a fungal infection of the nail.
AmorolfineAmorolfine or amorolfin, is a morpholine antifungal drug that inhibits the fungal enzymes D14 reductase and D7-D8 isomerase. This inhibition affects fungal sterol synthesis pathways, depleting ergosterol and causing ignosterol...
Undecylenic acidAn antifungal used to treat tinea species infections.
ChlorophetanolChlorophetanol is an agent known to have antifungal activities.
HachimycinNot Annotated
TolciclateNot Annotated
FenticonazoleNot Annotated
PecilocinNot Annotated
TribromometacresolNot Annotated
PyrrolnitrinNot Annotated
ChlormidazoleNot Annotated
TiclatoneNot Annotated
Ethyl hydroxybenzoateNot Annotated
EberconazoleNot Annotated
SulbentineNot Annotated
BromochlorosalicylanilideNot Annotated
DimazoleDimazole (diamthazole) is an antifungal. It was withdrawn in Franch in 1972 due to neuropsychiatric reactions.
FluconazoleA triazole antifungal used to treat various fungal infections including candidiasis.
OxiconazoleA topical antifungal used to treat a variety of dermatophyte infections.
ClotrimazoleA topical broad-spectrum antifungal agent used for the treatment of a wide variety of dermatophyte infections and candidiasis.
GriseofulvinAn antifungal agent used to treat a variety of superficial tinea infections and fungal infections of the fingernails and toes.
Gentian violet cationAn antiseptic violet dye used to prevent various infections, including fungal and bacterial infections.
NystatinA polyene ionophore antifungal used to treat cutaneous, mucocutaneous, and gastrointestinal mycotic infections, particularly those caused by Candida species.
ThiabendazoleA benzimidazole used in the treatment of strongyloides, cutaneous larva migrans, visceral larva migrans, and trichinosis infections.
NatamycinA macrolide antifungal used to treat fungal infections of the eye.
Salicylic acidAn acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts.
KetoconazoleA broad spectrum antifungal used to treat seborrheic dermatitis and fungal skin infections.
FlucytosineAn antifungal indicated only to treat severe infections throughout the body caused by susceptible strains of Candida or Cryptococcus.
EconazoleA topical antifungal used to treat tinea pedis, tinea cruris, tinea corporis, cutaneous candidiasis and tinea versicolor.
SertaconazoleA topical antifungal agent used in the treatment of interdigital tinea pedis in immunocompetent patients.
IsoconazoleIsoconazole is an azole antifungal drug that has similar effectiveness to clotrimazole in the treatment of foot and vaginal infections.
FlutrimazoleNot Annotated
MepartricinNot Annotated
OmoconazoleNot Annotated
TavaboroleAn antifungal agent used to treat onychomycosis, a fungal infection of the nail.
Drugs & Drug Targets
TolnaftateSqualene monooxygenasetarget
NaftifineSqualene monooxygenasetarget
ChlorphenesinCytochrome P450 19A1enzyme
ChlorphenesinCytochrome P450 3A4enzyme
ChlorphenesinXanthine dehydrogenase/oxidaseenzyme
ChlorphenesinProstaglandin G/H synthase 2enzyme
TerbinafineSqualene monooxygenasetarget
TerbinafineCytochrome P450 2D6enzyme
TerbinafineCytochrome P450 2C9enzyme
TerbinafineCytochrome P450 1A2enzyme
TerbinafineCytochrome P450 3A4enzyme
TerbinafineCytochrome P450 2C8enzyme
TerbinafineCytochrome P450 2C19enzyme
TerbinafineProstaglandin G/H synthase 1enzyme
TerbinafineSerum albumincarrier
Terbinafinealpha1-acid glycoproteincarrier
TerbinafineABC multidrug transporter MDR2transporter
TerbinafineSqualene monooxygenasetarget
TioconazoleLanosterol 14-alpha demethylasetarget
TioconazoleCytochrome P450 19A1enzyme
TioconazoleCytochrome P450 2C19enzyme
TioconazoleCytochrome P450 2E1enzyme
TioconazoleCytochrome P450 3A4enzyme
TioconazoleCytochrome P450 51target
ButenafineSqualene monooxygenasetarget
MiconazoleCytochrome P450 2C9enzyme
MiconazoleCytochrome P450 2D6enzyme
MiconazoleCytochrome P450 3A4enzyme
MiconazoleP-glycoprotein 1transporter
MiconazoleCytochrome P450 51target
MiconazoleNitric oxide synthase, endothelialtarget
MiconazoleNitric oxide synthase, inducibletarget
MiconazoleCytochrome P450 11B1, mitochondrialenzyme
MiconazoleCytochrome P450 2A6enzyme
MiconazoleCytochrome P450 2B6enzyme
MiconazoleCytochrome P450 2C19enzyme
MiconazoleCytochrome P450 2E1enzyme
MiconazoleNuclear receptor subfamily 1 group I member 2target
MiconazoleLanosterol 14-alpha demethylaseenzyme
MiconazoleCytochrome P450 19A1enzyme
MiconazoleCalcium-activated potassium channeltarget
MiconazoleVoltage-gated Potassium Channelstarget
MiconazoleInward rectifier potassium channeltarget
MiconazoleVoltage gated L-type calcium channeltarget
MiconazoleSerum albumincarrier
MiconazoleCytochrome P450 2C8enzyme
CiclopiroxSodium/potassium-transporting ATPase subunit alpha-1target
BifonazoleCytochrome P450 2B6target
BifonazoleCytochrome P450 51target
BifonazoleCytochrome P450 19A1enzyme
BifonazoleCytochrome P450 2E1enzyme
BifonazoleCytochrome P450 3A4enzyme
SulconazoleCytochrome P450 1A2enzyme
SulconazoleCytochrome P450 2C9enzyme
SulconazoleCytochrome P450 2D6enzyme
LuliconazoleCytochrome P450 51target
LuliconazoleCytochrome P450 3A4enzyme
LuliconazoleCytochrome P450 2C19enzyme
EfinaconazoleLanosterol 14-alpha demethylasetarget
FluconazoleCytochrome P450 3A4enzyme
FluconazoleCytochrome P450 2C9enzyme
FluconazoleCytochrome P450 2C19enzyme
FluconazoleP-glycoprotein 1transporter
FluconazoleCytochrome P450 51target
FluconazoleCytochrome P450 3A5enzyme
OxiconazoleCytochrome P450 51target
OxiconazoleLanosterol synthasetarget
OxiconazoleCytochrome P450 3A4enzyme
OxiconazoleCytochrome P450 2C19enzyme
OxiconazoleNuclear receptor subfamily 1 group I member 2target
ClotrimazoleIntermediate conductance calcium-activated potassium channel protein 4target
ClotrimazoleCytochrome P450 2D6enzyme
ClotrimazoleCytochrome P450 2C8enzyme
ClotrimazoleCytochrome P450 3A4enzyme
ClotrimazoleCytochrome P450 2B6enzyme
ClotrimazoleP-glycoprotein 1transporter
ClotrimazoleCytochrome P450 2A6enzyme
ClotrimazoleCytochrome P450 2C9enzyme
ClotrimazoleCytochrome P450 2E1enzyme
ClotrimazoleCytochrome P450 3A7enzyme
ClotrimazoleCytochrome P450 51target
ClotrimazoleNuclear receptor subfamily 1 group I member 2target
ClotrimazoleHydroxycarboxylic acid receptor 2target
ClotrimazoleBile salt export pumptransporter
ClotrimazoleSolute carrier organic anion transporter family member 1B1transporter
ClotrimazoleSolute carrier organic anion transporter family member 1B3transporter
GriseofulvinTubulin beta chaintarget
GriseofulvinKeratin, type I cytoskeletal 12target
GriseofulvinCytochrome P450 1A2enzyme
GriseofulvinCytochrome P450 3A4enzyme
Gentian violet cationDNAtarget
Gentian violet cationSolute carrier family 22 member 1transporter
NystatinSolute carrier organic anion transporter family member 1B1transporter
NystatinSolute carrier organic anion transporter family member 1B3transporter
ThiabendazoleFumarate reductase flavoprotein subunittarget
ThiabendazoleCytochrome P450 1A2enzyme
ThiabendazoleCytochrome P450 1A1enzyme
NatamycinCytochrome P450 3A4enzyme
Salicylic acidSerum albumincarrier
Salicylic acidProstaglandin G/H synthase 1target
Salicylic acidProstaglandin G/H synthase 2target
Salicylic acidAldo-keto reductase family 1 member C1target
Salicylic acidSolute carrier family 22 member 6transporter
Salicylic acidSolute carrier family 22 member 10transporter
Salicylic acidSolute carrier family 22 member 8transporter
Salicylic acidSolute carrier family 22 member 11transporter
Salicylic acidSolute carrier organic anion transporter family member 2B1transporter
Salicylic acidMonocarboxylate transporter 1transporter
Salicylic acidSolute carrier family 22 member 7transporter
Salicylic acidCytochrome P450 2C9enzyme
KetoconazoleCytochrome P450 3A4enzyme
KetoconazoleCytochrome P450 2C9enzyme
KetoconazoleCytochrome P450 2C19enzyme
KetoconazoleCytochrome P450 3A5enzyme
KetoconazoleCytochrome P450 1A2enzyme
KetoconazoleCytochrome P450 2C8enzyme
KetoconazoleCytochrome P450 1A1enzyme
KetoconazoleCytochrome P450 2D6enzyme
KetoconazoleBile salt export pumptransporter
KetoconazoleP-glycoprotein 1transporter
KetoconazoleCytochrome P450 11B1, mitochondrialenzyme
KetoconazoleCytochrome P450 1B1enzyme
KetoconazoleCytochrome P450 2A6enzyme
KetoconazoleCytochrome P450 2B6enzyme
KetoconazoleLanosterol 14-alpha demethylasetarget
KetoconazoleAndrogen receptortarget
KetoconazoleSteroid 17-alpha-hydroxylase/17,20 lyasetarget
KetoconazoleSteroid 21-hydroxylasetarget
KetoconazolePotassium voltage-gated channel subfamily H member 2target
KetoconazoleNuclear receptor subfamily 1 group I member 2target
KetoconazoleNuclear receptor subfamily 1 group I member 3target
KetoconazoleUDP-glucuronosyltransferase 1-1enzyme
KetoconazoleUDP-glucuronosyltransferase 2B7enzyme
KetoconazoleSolute carrier organic anion transporter family member 1B1transporter
KetoconazoleCytochrome P450 4F12enzyme
KetoconazoleLeukotriene-B(4) omega-hydroxylase 1enzyme
KetoconazoleSerum albumincarrier
KetoconazoleSex hormone-binding globulincarrier
KetoconazoleCytochrome P450 19A1enzyme
KetoconazoleUDP-glucuronosyltransferase 1-7enzyme
FlucytosineThymidylate synthasetarget
FlucytosineDNA (cytosine-5)-methyltransferase 1target
EconazoleCytochrome P450 19A1enzyme
EconazoleCytochrome P450 2E1enzyme
EconazoleCytochrome P450 3A4enzyme
EconazoleCytochrome P450 51target
EconazoleNuclear receptor subfamily 1 group I member 2target
SertaconazoleCytochrome P450 51target
MepartricinCytochrome P450 3A4enzyme
TavaboroleCytosolic leucyl-tRNA synthetasetarget