Cabozantinib

DB08875ApprovedInvestigationalSmall moleculeKinase Inhibitor

Cabozantinib is a tyrosine kinase inhibitor used to treat advanced renal cell carcinoma, hepatocellular carcinoma, and medullary thyroid cancer. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer.

Mechanism: Cabozantinib inhibits specific receptor tyrosine kinases such as VEGFR-1, -2 and -3, KIT, TRKB, FLT-3, AXL, RET, MET, and TIE-2.
Curator reviewed · 1 reference
Primary indication: Cabozantinib, marketed under the brand name Cometriq, is indicated for the treatment of progressive, metastatic medullary thyroid cancer (MTC).Curator reviewed · 16 structured indications
Formula / weight: C₂₈H₂₄FN₃O₅ · 501.514 g/mol (avg)
First approval: Canada, 2018 · United States, 2012 · European Union, 2016
Code names: BMS-907351 · XL-184
Brand names: Cabometyx
Cometriq

Resolves to

Compound

UNII1C39JW444GCAS849217-68-1ChEMBLCHEMBL2105717ChEBI72317PubChem25102847KEGGD10062

Clinical / RWD

RxNorm1363268ATCL01EX07

Structure

InChIKeyONIQOQHATWINJY-UHFFFAOYSA-NSMILESCOC1=CC2=C(C=C1OC)C(OC1=CC=C(NC(=O)C3(CC3)C(=O)NC3=CC=C(F)C=C3)C=C1)=CC=N2

Targets

P08581METP07949RETP35968KDRP17948FLT1P35916FLT4P10721KITQ16620NTRK2P36888FLT3+5 more

What you can answer from here — as of September 13, 2026

13Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

522Drug interactionsStructured to mechanism, not free text

253Clinical trialsPhase, status and sponsor resolved per trial

16Structured indicationsCondition, population, route and combination as fields, not prose

1ContraindicationEach with its own population and attribute set

47Marketed productsAcross 7 countries and 6 labellers

1ATC codeIncluding every combination product, plus 20 drug categories

38+ReferencesStructured and connected to the statements they support

Which drugs share a target with Cabozantinib, and which of those have an active Phase 3 trial?

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