Chlorotoxin I-131 is investigated in clinical trials for treating brain cancer. Chlorotoxin I-131 binds to and reduces the activity of a matrix metalloproteinase (MMP) that regulates functioning of the chloride... Chlorotoxin is a small 36-amino-acid peptide that selectively binds to glioma cells but not normal brain parenchyma.
- Mechanism
- Curator reviewed
TX binds to and reduces the activity of a matrix metalloproteinase (MMP) that is regulates functioning of the chloride channels on cell membranes. CTX reduced the migration ability of glioma cells through tight extracellular spaces in the brain tissue by inhibition of the MMP2, because this prevented the cells from shrinking and releasing from the extracellular matrix.
- Primary indication
- Investigated for use/treatment in various forms of brain cancer; Malignant Glioma, Glioblastoma Multiforme, GBM, Anaplastic Astrocytoma, Oligo-Astrocytoma, GliosarcomaCurator reviewed
- Formula / weight
- C26H31NO · 373.5304 g/mol (avg)
- Also known as
- I(131)-TM-601 (chlorotoxin)
- Code names
- I(131)-TM-601 · TM-601 I-131
Resolves to
YUFAHBUWIVNVNJ-UHFFFAOYSA-NSMILESCCC(C(C1=CC=CC=C1)C1=CC=C(OCCN(C)C)C=C1)C1=CC=CC=C1What you can answer from here — as of July 18, 2023
Which companies are running trials of Chlorotoxin I-131, in which indications and phases, and which of those programs are still active?
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