- Chelating Agents
- Accession Number
Chemicals that bind to and remove ions from solutions. Many chelating agents function through the formation of COORDINATION COMPLEXES with METALS.
Drug Drug Description Calcium acetate A phosphate binder used in patients with end-stage renal disease (ESRD) to prevent elevated phosphate levels and resulting ectopic calcification and secondary hyperparathyroidism. Succimer A mercaptodicarboxylic acid heavy metal chelator used in the treatment of heavy metal poisoning. Sevelamer A phosphate binder used to treat hyperphosphatemia. Deferoxamine A chelating agent used to treat iron or aluminum toxicity and some blood transfusion dependent anemias. Penicillamine A chelator used to treat Wilson's disease, cystinuria, and rheumatoid arthritis. Edetic acid A chelating agent used to treat mercury and lead toxicity and some blood transfusion dependent anemias. Tolevamer A potassium-binding resin used in the treatment of hyperkalemia. Deferasirox An iron chelator used to treat chronic iron overload caused by blood transfusions. Also used in patients with non-transfusion-dependent thalassemia syndromes, and in patients with elevated liver iron concentration and serum ferritin. 1,10-Phenanthroline Not Available Ditiocarb A chelating agent that has been used to mobilize toxic metals from the tissues of man and experimental animals. It is the main metabolite of DISULFIRAM. Nitrilotriacetic acid Nitrilotriacetic acid is a derivative of acetic acid, N(CH2COOH)3. It is a complexing (sequestering) agent that forms stable complexes with Zn2+. (From Miall's Dictionary of Chemistry, 5th ed.) Dipicolinic acid Not Available Citric acid An anti-chelation additive used in blood collection tubes and as a flavoring and preservative agent in various cosmetic and pharmaceutical products. Thenoyltrifluoroacetone Thenoyltrifluoroacetone is a chelating agent and inhibitor of cellular respiration. Tagatose Intended for use as a therapeutic adjunct in the treatment of type II diabetes. Tetrathiomolybdate Investigated for use/treatment in liver disease and pulmonary fibrosis. Alanosine Investigated for use/treatment in brain cancer and cancer/tumors (unspecified). Dimercaprol A chelating agent used as an antidote to arsenic, gold, and mercury poisoning, as well as acute lead poisoning in combination with edetate calcium disodium. Triethylenetetramine A copper chelating agent used for the management of Wilson's disease in cases where penicillamine therapy is clinically inappropriate. Deferiprone An iron chelator used to treat patients with transfusional iron overload caused by thalassemia syndromes. Gadoteric acid A diagnostic contrast agent used with magnetic resonance imaging to provide contrast enhancement for intracranial and spinal lesions with abnormal blood brain barrier or abnormal vascularity, and for whole body imaging. Poliglusam Poliglusam, or chitosan, is a linear polysaccharide consisting of D-glucosamine and N-acetyl-D-glucosamine. Naturally-occuring poliglusam is found in the cell walls of fungi, soil and sediments where it is produced from... Acteoside Acteoside is under investigation in clinical trial NCT02662283 (Validity and Security of Reh-acteoside Therapy for Patients of IgA Nephropathy). Pentetic acid DTPA is widely used in industry and medicine. As a medical agent, it is approved for its use in medical imaging and for the decorporation of internally deposited radionuclides. It... Gluconic Acid An electrolyte supplement used in total parenteral nutrition. L-tartaric acid Tartaric Acid is primarily indicated in conditions like Antiscorbutic, Antiseptic. Thiosulfuric acid A sulfur donor used for sequential use with sodium nitrite for the reversal of acute cyanide poisoning that is judged to be life-threatening. Emeramide Emeramide has been used in trials studying the treatment of Mercury Poisoning. Edetate disodium anhydrous A polyvalent ion chelator indicated for emergency treatment of hypercalcemia and digitalis toxicity associated ventricular arrhythmias. Edetate calcium disodium anhydrous A chelating agent used to treat lead poisoning. Dimercaptosuccinic acid Not Annotated 2,3-Dimercapto-1-propanesulfonic acid Not Annotated Ditiocarb zinc Ditiocarb Zinc is approved for use within allergenic epicutaneous patch tests which are indicated for use as an aid in the diagnosis of allergic contact dermatitis (ACD) in persons 6... Picolinic acid Investigated for use/treatment in acne, herpes labialis infections (cold sores), and venereal disease.
- Drugs & Drug Targets