Has antiproliferative effects on HIV-1 and reduces HIV-1 replication.
- Mechanism
- Curator reviewed
Fluasterone is a synthetically stable adrenocortical steroid fluorinated analogue of dehydroepiandrosterone (DHEA), a powerful anti-inflammatory molecule with androgenic or estrogenic side effects. It is proposed that fluasterone inhibits NF-kB activation and reduces oxidative stress, but other mechanisms may play a role. Fluasterone suppresses inflammation and is effective in preclinical models of chronic inflammatory disease including psoriasis, asthma, rheumatoid arthritis, multiple sclerosis and lupus erythematosus. Fluasterone has anti-inflammatory effects inpreclinical models of chronic inflammatory disease including psoriasis, asthma, rheumatoid arthritis, multiple sclerosis and lupus erythematosus. [Aeson Pharmaceuticals Executive Report]
- Primary indication
- Investigated for use/treatment in psoriasis and psoriatic disorders, hyperlipidemia, metabolic disease, cancer/tumors (unspecified), and obesity.Curator reviewed
- Formula / weight
- C19H27FO · 290.422 g/mol (avg)
- Code names
- HE-2500
Resolves to
VHZXNQKVFDBFIK-NBBHSKLNSA-NSMILESC[C@]12CC[C@H]3[C@@H](CC=C4CCCC[C@]34C)[C@@H]1C[C@@H](F)C2=OWhat you can answer from here — as of March 06, 2025
Which companies are running trials of Fluasterone, in which indications and phases, and which of those programs are still active?
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