Dry Skin (DBCOND0036024)

Identifiers

Synonyms

Xerosis Cutis / Xeroderma / Dryness of skin / Skin dry / Dryness of the skin / Skin dryness / Dry skin / Pruritus hiemalis / Winter eczema / Senile asteatotic eczema (disorder) / Xerotic eczema / Eczema craquele / Asteatosis / Eczema asteatotic / Winter itch (disorder) / Winter itch / Dry skin dermatitis (disorder) / Asteatotic eczema / Skin xerosis / Asteatosis cutis (disorder) / Other manifestations of vitamin A deficiency / Xeroderma (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Dexpanthenol	An alcoholic analogue of D-pantothenic acid that is used as a supplement or application to support a healthy epithelium and is also used to prevent vitamin deficiency in patients receiving total parenteral nutrition (TPN).	No drug targets
Dimethicone	An ingredient used to treat dry and irritated eyes.	No drug targets
Dimethicone 410	Dimethicone is approved as a transdermal drug delivery system. Dimethicone 410 is part of the simethicone element in Dow Corning Q7-2242 LVA which is an antifoam.[L2163, L2166] Some OTC's containing...	No drug targets
Glycerin	It is used as a solvent, emollient, pharmaceutical agent, and sweetening agent.	Group IIE secretory phospholipase A2target Inositol-3-phosphate synthase 1target All-trans-retinol dehydrogenase [NAD(+)] ADH1Btarget Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1target Glycodelintarget Alpha-N-acetylgalactosaminidasetarget ADP-ribosylation factor 1target Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1target DNA mismatch repair protein MutLtarget Ribonucleoside-diphosphate reductase 1 subunit betatarget Adenine DNA glycosylasetarget tRNA (cytosine(38)-C(5))-methyltransferasetarget Cytochrome P450 2E1enzyme Aldehyde dehydrogenase 1A1enzyme Peroxisome proliferator-activated receptor deltatarget Maleylacetoacetate isomerasetarget Aquaporin-7transporter Aquaporin-9transporter Glycerol uptake facilitator proteintransporter
Ichthammol	Ichthammol is also referred to as ammonium bituminosulfonate or ammonium bituminosulphonate. It is an ammonium salt of dark sulfonated shale oil (bituminous schists) produced via distillation of the oil followed...	No drug targets
Linoleic acid	Not Annotated	Fatty acid-binding protein, adipocytetarget
Metronidazole	A nitroimidazole used to treat trichomoniasis, amebiasis, inflammatory lesions of rosacea, and bacterial infections, as well as prevent postoperative infections.	Oxygen-insensitive NADPH nitroreductasetarget Cytochrome P450 2C9enzyme Cytochrome P450 3A4enzyme Cytochrome P450 2C8enzyme UDP-glucuronosyltransferase 1A1enzyme Anaerobic bacterial DNAtarget Protozoal DNAtarget ATP-dependent translocase ABCB1transporter Cytochrome P450 2A6enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme
Palmitic Acid	A fatty used as a food additive and emollient or surfactant in cosmetics.	Rhodopsintarget Albumincarrier Palmitoyl-protein thioesterase 1target Myelin P2 proteintarget Fatty acid-binding protein, adipocytecarrier Fatty acid-binding protein 5carrier Glycodelintarget Fatty acid-binding protein, heartcarrier Hepatocyte nuclear factor 4-gammatarget Lipid binding proteintarget Cytochrome P450 2C8target Trafficking protein particle complex subunit 3target Fatty acid-binding protein TM_1468target Fatty acid-binding protein, intestinalcarrier Alpha-lactalbumintarget Peroxisome proliferator-activated receptor alphatarget Fatty acid-binding protein, adipocytetarget Fatty acid-binding protein 5target
Panthenol	An ingredient used in skin, hair care, and nutritional products but is not an approved medication.	No drug targets
Peanut oil	A compound used to lubricate ear wax, as an emollient, and used in laxatives.	No drug targets
Petrolatum	For use as an over the counter skin protectant [FDA Label]. Commonly used to treat diaper rash and chapped lips [FDA Label] .	No drug targets
Pidolic acid	There is currently no clinically approved and/or marketed medicine that relies upon pidolic acid as an active ingredient for any formal therapeutic indication. Although pidolic acid may be sold in...	Alpha-amylase 2Btarget Vascular endothelial growth factor A, long formtarget Pancreatic alpha-amylasetarget Immunoglobulin lambda constant 1target Immunoglobulin lambda variable 2-8target Trefoil factor 2target Cytochrome c2target Disintegrin and metalloproteinase domain-containing protein 28target Endo-1,4-beta-xylanasetarget Copper-containing nitrite reductasetarget Keratin-associated protein 5-2target Hypocretin neuropeptide precursortarget C-C motif chemokine 8target Cytochrome c'target Pancreatic alpha-amylaseenzyme
Pine tar	A medication indicated in itchy, inflamed, and flaky skin conditions.	No drug targets
Urea	A keratolytic emollient used to treat hyperkeratotic lesions and moisturize the skin.	Arginase-1target Carbonic anhydrase 2target Catenin beta-1target Sulfoxide reductase catalytic subunit YedYtarget Urea transporter 2transporter Urea transporter 1transporter Dihydrofolate reductasetarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT05639933	Study to Investigate the Efficacy, Safety, and Tolerability of Topical HT-001 for the Treatment of Skin Toxicities Associated With Epidermal Growth Factor Receptor Inhibitors	No drug interventions	supportive_care	2	recruiting
NCT02557698	Effectiveness of Using an Oil Bath Additive	No drug interventions	treatment	Not Available	completed
NCT05046015	Comparison Dry Foot Skin Between Diabetic and Non-diabetic Subjects and the Effects of Two Cosmetic Foot Care Products	No drug interventions	treatment	Not Available	completed
NCT04253704	Effects of 2% IDL Lotion on Skin Hydration and Transepidermal Water Loss in Females With Dry Skin	No drug interventions	treatment	1 / 2	completed
NCT03815305	Effect of Centella Asiatica on Xerotic Skin in Diabetes Mellitus Type 2	Centella asiatica Petrolatum	treatment	4	unknown_status
NCT03093597	Skin Barrier Biophysical Properties and Clinical Appearance After Moisturizer in Dry Skin	No drug interventions	treatment	Not Available	completed
NCT04127513	Comparison of 12% Ammonium Lactate and 10% Urea Cream in Geriatric With Xerosis Cutis	Ammonium lactate Urea	treatment	3	completed
NCT03824886	Enhancing SKIN Health and Safety in Aged CARE	No drug interventions	prevention	Not Available	completed
NCT02216526	Skin Health and Effectiveness of Standardized Skin Care Regimens in Nursing Home Residents	No drug interventions	treatment	Not Available	completed
NCT06178367	Effectiveness and Safety of Topical Hyaluronic Acid of Different Molecular Weights in Xerotic Skin Treatment	Hyaluronic acid	treatment	3	completed
NCT05932732	Trial Assessing the Impact on Facial Skin Quality, Hydration, and Skin Barrier of Three (3) Hydrafacial Treatments in Adults of All Skin Types.	Minoxidil	treatment	4	active_not_recruiting
NCT05041205	Functional Test for a Drink Powder Alone and Combined Use With a Cosmetic Apparatus	No drug interventions	treatment	Not Available	completed
NCT06219213	Glyceryl Eicosapentaenoate Based Topic Products as an Irritant-free Cream and Serum for Hydration of Sensitive Skin	No drug interventions	basic_science	Not Available	recruiting
NCT06000839	A Safety and Effectiveness Study of CELLBOOSTER® Lift (Stabilized Booster Complex Using CHAC Technology)	No drug interventions	treatment	Not Available	completed
NCT05646953	Safety and Efficacy Study of Vasu Facial Beauty Oil	No drug interventions	other	Not Available	completed
NCT05013645	Evaluation of Skin Hydration in Adults With Dry Skin Using a Moisturizer With an Added Sterilized Probiotic	No drug interventions	other	Not Available	active_not_recruiting
NCT05059197	Efficacy and Safety of AP Collagen Peptide on the Skin	No drug interventions	supportive_care	Not Available	completed
NCT06489600	A Clinical Study to Assess the Safety, In-use Tolerability of Test Product in Healthy Adult Subjects With Dry and Sensitive Skin.	No drug interventions	other	Not Available	not_yet_recruiting
NCT05872113	Evaluation of Human Efficacy for Skin Moisturization and Wrinkle Improvement	No drug interventions	basic_science	Not Available	completed
NCT00368563	A Capacitance and Transepidermal Water Loss Test to Determine the Ability of Sunscreen to Moisturize Skin	No drug interventions	Not Available	2 / 3	completed
NCT05972512	A Clinical Study to Assess the Safety and Effectiveness of Plant-based Biotin and Plant Based Biotin With Silica in Healthy Human Subjects With Complaints of Hair Fall, Thin, Dry, & Brittle Hair, and Dry Skin	No drug interventions	prevention	Not Available	recruiting
NCT03804710	To Evaluate the Effect of Moisturizing Creams on Skin Barrier Function	No drug interventions	other	Not Available	completed
NCT04085809	This Was a Clinical Study Investigating the Moisturization and Desquamation Effect of AmLactin® Rapid Relief Restoring Lotion + Ceramides on Dry Skin in Healthy Female Volunteers. AmLactin® Rapid Relief is an Over-the-counter Cosmetic	No drug interventions	treatment	Not Available	completed
NCT06489418	A Clinical Study to Assess the Safety and Effectiveness of Test Product in Healthy Adult Human Subjects With Dry and Sensitive Skin.	No drug interventions	other	Not Available	not_yet_recruiting
NCT05982535	Neopep-S Ingredient Easy Dew MD Regen Cream	No drug interventions	supportive_care	Not Available	completed
NCT01305057	Efficacy Test on Skin Hydration and Skin Barrier Function	No drug interventions	health_services_research	Not Available	completed