This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Explore a selection of our essential drug information below, or:
Identification
- Generic Name
- Octamoxin
- DrugBank Accession Number
- DB09249
- Background
Octamoxin, also known as 2-octylhydrazine, is both an irreversible and nonselective monoamine oxidase enzyme inhibitor (MAOI) of the hydrazine chemical class. This drug was used in the past as an antidepressant agent in the 1960s, however, has since been discontinued.
- Type
- Small Molecule
- Groups
- Withdrawn
- Structure
Structure for Octamoxin (DB09249)
- Weight
- Average: 144.262
Monoisotopic: 144.162648652 - Chemical Formula
- C8H20N2
- Synonyms
- 2-octylhydrazine
- Octamoxin
Pharmacology
- Indication
For the treatment of depression.
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Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
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Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your software1,2-Benzodiazepine The risk or severity of CNS depression can be increased when Octamoxin is combined with 1,2-Benzodiazepine. Abaloparatide Octamoxin may increase the orthostatic hypotensive activities of Abaloparatide. Abciximab The risk or severity of bleeding and hemorrhage can be increased when Octamoxin is combined with Abciximab. Acarbose Octamoxin may increase the hypoglycemic activities of Acarbose. Acebutolol Octamoxin may increase the hypotensive activities of Acebutolol. - Food Interactions
- Not Available
Products
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- Nimaol / Ximaol
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as alkylhydrazines. These are organonitrogen compounds that containing a hydrazine group to which an alkyl group is attached.
- Kingdom
- Organic compounds
- Super Class
- Organic nitrogen compounds
- Class
- Organonitrogen compounds
- Sub Class
- Hydrazines and derivatives
- Direct Parent
- Alkylhydrazines
- Alternative Parents
- Organopnictogen compounds / Hydrocarbon derivatives
- Substituents
- Aliphatic acyclic compound / Alkylhydrazine / Hydrocarbon derivative / Organopnictogen compound
- Molecular Framework
- Aliphatic acyclic compounds
- External Descriptors
- Not Available
- Affected organisms
- Humans and other mammals
Chemical Identifiers
- UNII
- 0HXY3M6S54
- CAS number
- 4684-87-1
- InChI Key
- FODQIVGFADUBKE-UHFFFAOYSA-N
- InChI
- InChI=1S/C8H20N2/c1-3-4-5-6-7-8(2)10-9/h8,10H,3-7,9H2,1-2H3
- IUPAC Name
- (octan-2-yl)hydrazine
- SMILES
- CCCCCCC(C)NN
References
- General References
- Gayral L, Stern H, Puyuelo R: [Indications and results of the treatment of mental depression by octamoxine (ximaol)]. Therapie. 1966 Sep-Oct;21(5):1183-90. [Article]
- External Links
Clinical Trials
- Clinical Trials
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Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 6.27 mg/mL ALOGPS logP 2.54 ALOGPS logP 2.26 Chemaxon logS -1.4 ALOGPS pKa (Strongest Basic) 5.92 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 38.05 Å2 Chemaxon Rotatable Bond Count 6 Chemaxon Refractivity 56.99 m3·mol-1 Chemaxon Polarizability 19.11 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted GC-MS Spectrum - GC-MS Predicted GC-MS splash10-0a4i-9100000000-f73508c11a24d1cfb41b Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS splash10-0002-9700000000-6cbe61f56c268c335e35 Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS splash10-0006-0900000000-edb0c370fb2ad3dc9aad Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS splash10-0abc-9000000000-bddbc3d0704978288726 Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS splash10-01ox-0900000000-b1807a9e2aa4d0e5629b Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS splash10-052f-9000000000-86ac98ca311e115fed14 Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS splash10-05bf-9100000000-953be9d74cdf9d4a6899 Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 135.16231 predictedDeepCCS 1.0 (2019) [M+H]+ 138.27223 predictedDeepCCS 1.0 (2019) [M+Na]+ 147.24559 predictedDeepCCS 1.0 (2019)
Drug created at October 24, 2015 04:02 / Updated at February 21, 2021 18:52