Monoamine Oxidase Inhibitors

Monoamine Oxidase Inhibitors
Accession Number
DBCAT001004  (DBCAT002868)

A chemically heterogeneous group of drugs that have in common the ability to block oxidative deamination of naturally occurring monoamines. (From Gilman, et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p414)

ATC Classification
DrugDrug Description
TranylcypromineA monoamine oxidase inhibitor used to treat major depressive disorder.
PhenelzineA monoamine oxidase inhibitor used to treat atypical, nonendogenous, or neurotic depression.
SelegilineA monoamine oxidase inhibitor used to treat major depressive disorder and Parkinson's.
MoclobemideA monoamine oxidase inhibitor used in the treatment of major depressive disorder and bipolar disorder.
IsocarboxazidA monoamine oxidase inhibitor used to treat enduring and debilitating symptoms of depression following inadequate clinical response to other antidepressant drugs.
RasagilineAn irreversible inhibitor of monoamine oxidase used for the symptomatic management of idiopathic Parkinson's disease as initial monotherapy and as adjunct therapy to levodopa.
PargylineFor the treatment of moderate to severe hypertension.
MinaprineFor the treatment of depression
IproniazidFor the treatment of depression (originally intended to treat tuberculosis).
NialamideWithdrawn from the Canadian, US, and UK markets in 1963 due to interactions with food products containing tyrosine.
PirlindoleFor the treatment of major depression. It is being studied in the treatment of fibromyalgia pain syndrome. One study determined that the effect of pirlindole on sensorimotor performance while driving...
ToloxatoneFor the treatment of major depressive disorder.
HydracarbazineWas used for the treatment of hypertension .
Methylene blueAn oxidation-reduction agent used for the treatment of pediatric and adult patients with acquired methemoglobinemia.
BenmoxinFor the treatment of depression.
MebanazineFor the treatment of depression.
OctamoxinFor the treatment of depression.
PheniprazineFor the treatment of depression, schizophrenia, and angina pectoris.
PhenoxypropazineFor the treatment of depression.
PivhydrazineFor the treatment of depression.
SafrazineFor the treatment of depression.
CaroxazoneFor the treatment of depression.
FurazolidoneA drug for the treatment of infectious diarrhea.
7,8-Dichloro-1,2,3,4-tetrahydroisoquinolinePotent reversible inhibitor of phenylethanolamine N-methyltransferase.
HarmalineNot Annotated
BrofaromineNot Annotated
ProcaineA local anesthetic used for anesthesia, peripheral nerve block, and spinal nerve block.
ProcarbazineAn antineoplastic agent indicated for the treatment of stage III and stage IV Hodgkin's disease in combination with other chemotherapeutic agents.
LinezolidAn oxazolidinone antibiotic used to treat infections by susceptible strains of aerobic Gram-positive bacteria.
SafinamideA MAO-B inhibitor used as an add-on treatment to levodopa/carbidopa for Parkinson's disease during "off" episodes.
ClorgilineAn antidepressive agent and monoamine oxidase inhibitor related to PARGYLINE.
HarmineNot Available
Drugs & Drug Targets
TranylcypromineAmine oxidase [flavin-containing] Btarget
TranylcypromineAmine oxidase [flavin-containing] Atarget
TranylcypromineCytochrome P450 2C19enzyme
TranylcypromineCytochrome P450 2A6enzyme
TranylcypromineCytochrome P450 2D6enzyme
TranylcypromineCytochrome P450 1A2enzyme
TranylcypromineCytochrome P450 2C9enzyme
TranylcypromineCytochrome P450 3A4enzyme
PhenelzineMembrane primary amine oxidasetarget
PhenelzineAmine oxidase [flavin-containing] Btarget
PhenelzineAmine oxidase [flavin-containing] Atarget
PhenelzineAmine oxidase [flavin-containing] Aenzyme
PhenelzineAmine oxidase [flavin-containing] Benzyme
PhenelzineCytochrome P450 2E1enzyme
Phenelzine4-aminobutyrate aminotransferase, mitochondrialtarget
PhenelzineGlutamic acid decarboxylasetarget
PhenelzineAlanine aminotransferase 1target
PhenelzineAlanine aminotransferase 2target
PhenelzineCytochrome P450 2C19enzyme
PhenelzineCytochrome P450 2C8enzyme
PhenelzineCytochrome P450 3A4enzyme
PhenelzineCytochrome P450 3A5enzyme
PhenelzineCytochrome P450 3A7enzyme
PhenelzineCytochrome P450 2D6enzyme
PhenelzineCytochrome P450 3A Subfamilyenzyme
SelegilineAmine oxidase [flavin-containing] Btarget
SelegilineCytochrome P450 2B6enzyme
SelegilineAmine oxidase [flavin-containing] Atarget
SelegilineCytochrome P450 2A6enzyme
SelegilineCytochrome P450 3A4enzyme
SelegilineP-glycoprotein 1transporter
SelegilineCytochrome P450 1A2enzyme
SelegilineCytochrome P450 2C19enzyme
SelegilineCytochrome P450 2C8enzyme
SelegilineCytochrome P450 2C9enzyme
SelegilineCytochrome P450 2D6enzyme
MoclobemideAmine oxidase [flavin-containing] Atarget
MoclobemideCytochrome P450 2C19enzyme
MoclobemideCytochrome P450 2D6enzyme
MoclobemideAmine oxidase [flavin-containing] Aenzyme
MoclobemideAmine oxidase [flavin-containing] Benzyme
MoclobemideCytochrome P450 2C9enzyme
MoclobemideMonoamine oxidasetarget
MoclobemideAmine oxidase [flavin-containing] Btarget
IsocarboxazidAmine oxidase [flavin-containing] Atarget
IsocarboxazidAmine oxidase [flavin-containing] Btarget
RasagilineApoptosis regulator Bcl-2target
RasagilineAmine oxidase [flavin-containing] Btarget
RasagilineCytochrome P450 1A2enzyme
PargylineAmine oxidase [flavin-containing] Btarget
PargylineAmine oxidase [flavin-containing] Atarget
MinaprineDopamine D1 receptortarget
MinaprineDopamine D2 receptortarget
Minaprine5-hydroxytryptamine receptor 2Atarget
Minaprine5-hydroxytryptamine receptor 2Btarget
Minaprine5-hydroxytryptamine receptor 2Ctarget
MinaprineSodium-dependent serotonin transportertarget
MinaprineCytochrome P450 2D6enzyme
MinaprineMuscarinic acetylcholine receptor M1target
MinaprineAmine oxidase [flavin-containing] Atarget
IproniazidAmine oxidase [flavin-containing] Benzyme
IproniazidCytochrome P450 2D6enzyme
IproniazidCytochrome P450 2C9enzyme
IproniazidAmine oxidase [flavin-containing] Aenzyme
NialamideAmine oxidase [flavin-containing] Btarget
NialamideAmine oxidase [flavin-containing] Atarget
NialamideCatechol O-methyltransferasetarget
PirlindoleAmine oxidase [flavin-containing] Atarget
Pirlindole5-hydroxytryptamine receptor 1Atarget
PirlindoleAlpha-2A adrenergic receptortarget
PirlindoleAmine oxidase [flavin-containing] Aenzyme
ToloxatoneAmine oxidase [flavin-containing] Atarget
ToloxatoneAmine oxidase [flavin-containing] Aenzyme
Methylene blueGuanylate cyclase soluble subunit alpha-2target
Methylene blueNitric oxide synthase, braintarget
Methylene blueUDP-glucuronosyltransferase 1-4enzyme
Methylene blueUDP-glucuronosyltransferase 1-9enzyme
Methylene blueCytochrome P450 1A2enzyme
Methylene blueCytochrome P450 2B6enzyme
Methylene blueCytochrome P450 2C8enzyme
Methylene blueCytochrome P450 2C9enzyme
Methylene blueCytochrome P450 2C19enzyme
Methylene blueCytochrome P450 3A4enzyme
Methylene blueCytochrome P450 3A5enzyme
Methylene blueSerum albumincarrier
Methylene blueP-glycoprotein 1transporter
Methylene blueSolute carrier family 22 member 2transporter
Methylene blueMultidrug and toxin extrusion protein 2transporter
Methylene blueMultidrug and toxin extrusion protein 1transporter
Methylene blueFlavin reductase (NADPH)enzyme
Methylene blueCytochrome P450 2D6enzyme
FurazolidoneAmine oxidase [flavin-containing] Benzyme
FurazolidoneAmine oxidase [flavin-containing] Aenzyme
7,8-Dichloro-1,2,3,4-tetrahydroisoquinolinePhenylethanolamine N-methyltransferasetarget
HarmalineHistamine N-methyltransferasetarget
BrofaromineAmine oxidase [flavin-containing] Atarget
ProcaineSodium channel protein type 10 subunit alphatarget
ProcaineGlutamate receptor ionotropic, NMDA 3Atarget
Procaine5-hydroxytryptamine receptor 3Atarget
ProcaineSodium-dependent dopamine transportertarget
ProcaineNeuronal acetylcholine receptor subunit alpha-2target
ProcaineDNA (cytosine-5)-methyltransferase 1target
ProcaineCalcium-activated potassium channeltarget
ProcaineCytosolic phospholipase A2target
Procaine60 kDa lysophospholipasetarget
ProcaineMonoamine oxidasetarget
ProcaineSodium-dependent dopamine transportertransporter
ProcaineSodium-dependent noradrenaline transportertransporter
ProcaineSodium-dependent serotonin transportertransporter
ProcaineDNA (cytosine-5)-methyltransferase 3Atarget
ProcarbazineXanthine dehydrogenase/oxidaseenzyme
ProcarbazineMonoamine oxidasetarget
Linezolid23S ribosomal RNAtarget
LinezolidAmine oxidase [flavin-containing] Aenzyme
LinezolidAmine oxidase [flavin-containing] Benzyme
LinezolidSerum albumincarrier
LinezolidSolute carrier family 22 member 6transporter
LinezolidSolute carrier family 22 member 8transporter
SafinamideAmine oxidase [flavin-containing] Btarget
SafinamideAmine oxidase [flavin-containing] Aenzyme
SafinamideATP-binding cassette sub-family G member 2transporter
SafinamideSolute carrier organic anion transporter family member 3A1transporter
SafinamideCytochrome P450 3A4enzyme
SafinamideCytochrome P450 1A1enzyme
SafinamideCytochrome P450 1A2enzyme
SafinamideCytochrome P450 2D6enzyme
SafinamideCytochrome P450 2C19enzyme
SafinamideCytochrome P450 3A5enzyme
ClorgilineAmine oxidase [flavin-containing] Atarget
HarmineAmine oxidase [flavin-containing] Atarget