Agents that reduce seizure threshold
- Agents that reduce seizure threshold
- Accession Number
Drug Drug Description Borage oil Borage oil, or borage seed oil, is a rich source of gamma-linolenic acid (GLA) that is obtained from the seeds of the Borago officinalis (borage). Borage oil is used as... Evening primrose oil Evening primrose oil is used as part of over-the-counter dietary supplements. It is also used for the treatment of systemic inflammatory diseases and for women's health conditions such as cyclical... Gamolenic acid An ingredient found in a variety of nutritional products. Sage oil Sage oil is extracted from sage or Salvia officinalis, the herb commonly used for culinary purposes. Salvia officinalis is a common sage and a member of the genus Salvia, that... Centella asiatica Centella asiatica is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug. Aminophylline A bronchodilator consisting of theophylline that is used for the treatment of bronchospasm due to asthma, emphysema and chronic bronchitis. Theophylline A xanthine used to manage the symptoms of asthma, COPD, and other lung conditions caused by reversible airflow obstruction. Isoniazid An antibiotic used to treat mycobacterial infections; most commonly use in combination with other antimycobacterial agents for the treatment of active or latent tuberculosis. Lindane An ectoparasiticide and ovicide used in the treatment of Pediculosis humanis capitis (head lice) and Phthirus pubis (crab lice). Metronidazole A nitroimidazole used to treat trichomoniasis, amebiasis, inflammatory lesions of rosacea, and bacterial infections, as well as prevent postoperative infections. Nalidixic acid A quinolone antibiotic used to treat urinary tract infections. Bupropion A norepinephrine and dopamine reuptake inhibitor used in the treatment of major depressive disorder (MDD), seasonal affective disorder (SAD), and as an aid to smoking cessation. Enflurane A halogenated inhalational anesthetic agent used for the induction and maintenance of anesthesia and for analgesia during labor and delivery. Chlorambucil A chemotherapy agent used in the management of chronic lymphocytic leukemia and malignant lymphomas. Cyclosporine A steroid-sparing immunosuppressant used in organ and bone marrow transplants as well as inflammatory conditions such as ulcerative colitis, rheumatoid arthritis, and atopic dermatitis. Lidocaine A local anesthetic used in a wide variety of superficial and invasive procedures. Bupivacaine A local anesthetic used in a wide variety of superficial and invasive procedures. Procaine A local anesthetic used for anesthesia, peripheral nerve block, and spinal nerve block. Fentanyl An opioid analgesic used in anesthesia, for breakthrough cancer pain, or round the clock pain management. Meperidine An opioid agonist with analgesic and sedative properties used to manage severe pain. Pentazocine An analgesic used to treat moderate to severe pain. Dextropropoxyphene An opioid analgesic used to treat mild to moderate pain. Levopropoxyphene Levopropoxyphene was used as an antitussive. An antitussive is a medication often recommended for the treatment of cough and associated respiratory tract disorders. Its enantiomer, dextropropoxyphene, presents an analgesic effect. Amphetamine A CNS stimulant and sympathomimetic agent indicated for the treatment of Attention Deficit Hyperactivity Disorder (ADHD). Cocaine An ester local anesthetic used during diagnostic procedures and surgeries in or through the nasal cavities. Methylphenidate A stimulant used in the management of Attention Deficit Hyperactivity Disorder (ADHD). Phenylpropanolamine A sympathomimetic that was previously used in nasal decongestants and weight loss products, but has been withdrawn by the FDA due to safety risks and lack of efficacy. Clozapine An antipsychotic drug used in treatment resistant schizophrenia and to decrease suicide risk in schizophrenic patients. Phenothiazine Phenothiazine (PTZ) is an organic thiazine compound. Isoflurane An inhaled general anesthetic used in surgery. Propofol A medication used in general anesthesia and for sedation. Fospropofol A sedative-hypnotic agent indicated for monitored anesthesia care (MAC) sedation in adult patients undergoing diagnostic or therapeutic procedures. Cephalosporin C Not Available Cephalosporin analog Not Available Deacetoxycephalosporin C Not Available Cefalotin A broad-spectrum cephalosporin antibiotic used for the treatment of serious bacterial infections in various locations, such as the urinary tract, skin, bone, and lower respiratory tract. Amphotericin B An antifungal used to treat fungal infections in neutropenic patients, cryptococcal meningitis in HIV infection, fungal infections, and leishmaniasis. Imipenem A carbapenem antibiotic normally administered with cilastatin to treat a variety of infections. Azatadine An H1 receptor antagonist used to treat perennial and allergic rhinitis as well as eustachian tube congestion. Cyproheptadine A combined serotonin and histamine antagonist used in the treatment of allergic symptoms, for appetite stimulation, and off-label in the treatment of serotonin syndrome. Dexchlorpheniramine A chlorpheniramine enantiomer antihistamine indicated in the treatment of sunburns, insect bites, and allergic reactions of the skin. Dexchlorpheniramine maleate A first generation antihistamine used to treat allergic and vasomotor rhinitis, allergic conjunctivitis, and mild urticaria and angioedema. Methdilazine Used for the symptomatic relief of hypersensitivity reactions and particularly for the control of pruritic skin disorders Promethazine A first-generation antihistamine used for the treatment of allergic conditions, nausea and vomiting, and motion sickness. Maprotiline A tetracyclic antidepressant used to treat depressive illness, major depressive disorder, bipolar disorder, and anxiety associated with depression. Clomipramine A tricyclic antidepressant used in the treatment of obsessive-compulsive disorder and disorders with an obsessive-compulsive component, such as depression, schizophrenia, and Tourette’s disorder. Chlorpromazine A phenothiazine antipsychotic used to treat nausea, vomiting, preoperative anxiety, schizophrenia, bipolar disorder, and severe behavioral problems in children. Phenelzine A monoamine oxidase inhibitor used to treat atypical, nonendogenous, or neurotic depression. Tranylcypromine A monoamine oxidase inhibitor used to treat major depressive disorder. Fluoxetine A selective serotonin reuptake inhibitor used to treat major depressive disorder, bulimia, OCD, premenstrual dysphoric disorder, panic disorder, and bipolar I. Sertraline A selective serotonin reuptake inhibitor (SSRI) indicated to treat major depressive disorder, social anxiety disorder and many other psychiatric conditions. Desmethylsertraline Desmethylsertraline is a metabolite of sertraline. Desvenlafaxine An antidepressant agent and SNRI used for the treatment of major depressive disorders in adults. Venlafaxine A selective serotonin and norepinephrine reuptake inhibitor (SNRI) used for the treatment of major depression. Trazodone A serotonin uptake inhibitor used to treat major depressive disorder. Fluphenazine A phenothiazine used to treat patients requiring long-term neuroleptic therapy. Haloperidol An antipsychotic agent used to treat schizophrenia and other psychoses, as well as symptoms of agitation, irritability, and delirium. Pimozide An antipsychotic used to manage debilitating motor and phonic tics in patients with Tourette's Disorder. Risperidone A second-generation antipsychotic medication used to treat a number of mental health disorders including schizophrenia, bipolar mania, psychosis, or as an adjunct in severe depression. Mefloquine An antimalarial agent used in the prophylaxis and treatment of malaria caused by Plasmodium falciparum and Plasmodium vivax. Chloroquine An antimalarial drug used to treat susceptible infections with P. vivax, P. malariae, P. ovale, and P. falciparum. It is also used for second line treatment for rheumatoid arthritis. Linezolid An oxazolidinone antibiotic used to treat infections by susceptible strains of aerobic Gram-positive bacteria. Furazolidone A drug for the treatment of infectious diarrhea. Minaprine For the treatment of depression Selegiline A monoamine oxidase inhibitor used to treat major depressive disorder and Parkinson's. Moclobemide A monoamine oxidase inhibitor used in the treatment of major depressive disorder and bipolar disorder. Isocarboxazid A monoamine oxidase inhibitor used to treat enduring and debilitating symptoms of depression following inadequate clinical response to other antidepressant drugs. Rasagiline An irreversible inhibitor of monoamine oxidase used for the symptomatic management of idiopathic Parkinson's disease as initial monotherapy and as adjunct therapy to levodopa. Pargyline For the treatment of moderate to severe hypertension. Iproniazid For the treatment of depression (originally intended to treat tuberculosis). Nialamide Withdrawn from the Canadian, US, and UK markets in 1963 due to interactions with food products containing tyrosine. Safinamide A MAO-B inhibitor used as an add-on treatment to levodopa/carbidopa for Parkinson's disease during "off" episodes. Methylene blue An oxidation-reduction agent used for the treatment of pediatric and adult patients with acquired methemoglobinemia. Hydracarbazine Was used for the treatment of hypertension . Pirlindole For the treatment of major depression. It is being studied in the treatment of fibromyalgia pain syndrome. One study determined that the effect of pirlindole on sensorimotor performance while driving... Toloxatone For the treatment of major depressive disorder. Benmoxin For the treatment of depression. Mebanazine For the treatment of depression. Octamoxin For the treatment of depression. Pheniprazine For the treatment of depression, schizophrenia, and angina pectoris. Phenoxypropazine For the treatment of depression. Pivhydrazine For the treatment of depression. Safrazine For the treatment of depression. Caroxazone For the treatment of depression. Harmaline Not Annotated Disulfiram A carbamate derivative used to treat alcohol addiction. Quinine An alkaloid used to treat uncomplicated Plasmodium falciparum malaria. Quinidine A medication used to restore normal sinus rhythm, treat atrial fibrillation and flutter, and treat ventricular arrhythmias. Halofantrine An antimalarial used for the treatment of severe malaria. Ganciclovir A DNA polymerase inhibitor used to treat cytomegalovirus and herpetic keratitis of the eye. Valganciclovir An antiviral medication used to treat cytomegalovirus (CMV) retinitis in patients diagnosed with acquired immunodeficiency syndrome (AIDS). Amitriptyline A tricyclic antidepressant indicated in the treatment of depressive illness, either endogenous or psychotic, and to relieve depression associated anxiety. Protriptyline A tricyclic antidepressant that is indicated in the treatment of depression only under close clinical supervision. Imipramine A tricyclic antidepressant indicated for the treatment of depression and to reduce childhood enuresis. Nortriptyline A tricyclic antidepressant used in the treatment of depression. Amoxapine A tricyclic antidepressant used in the treatment of neurotic or reactive depressive disorders and endogenous or psychotic depression. Trimipramine A tricyclic antidepressant used to treat depression. Cyclobenzaprine A skeletal muscle relaxant that works on the brainstem to treat muscle spasms of local origin. Doxepin A psychotropic agent used for the treatment of depression, anxiety, manic-depressive disorder, and insomnia. Desipramine A tricyclic antidepressant used in the treatment of depression. Amineptine For the treatment of depression. Dimetacrine Dimetacrine is also known as dimethacrine or acripamine. It is marketed under the names Istonil, Istonyl, Linostil, and Miroistonil. Dimetacrine is a tricyclic antidepressant (TCA) with imipramine-like effects used in... Butriptyline Butriptyline is a tricyclic antidepressant which has been used in Europe since 1974. It is the isobutyl side chain homologue of amitriptyline. Dosulepin A tricyclic antidepressant commonly used only in patients for whom alternative therapies are ineffective due to its toxicity potential. Tianeptine An atypical tricyclic antidepressant with antidepressant and anxiolytic effects primarily used to treat major depressive disorder. Oxaprotiline Investigated for the treatment of depression. Opipramol A medication to treat general anxiety and somatoform disorders. Amitriptylinoxide A tricyclic antidepressant indicated in the treatment of depressive disorders. Dibenzepin Dibenzepin is approved for use in Europe. Quinupramine Quinupramine has been approved in France under the brand name Kinupril, as an antidepressant . Melitracen A thioxanthene neuroleptic indicated in the treatment of anxiety, depression, and asthenia. Lofepramine Not Annotated Iprindole Not Annotated Imipramine oxide Not Annotated Tramadol A centrally-acting opioid agonist and SNRI (serotonin/norepinephrine reuptake inhibitor) used for the management of moderate to severe pain in adults. Sodium phosphate, monobasic A source of phosphorus used prevent or correct hypophosphatemia in patients with restricted or no oral intake. Cefotaxime A third generation cephalosporin used to treat susceptible Gram negative and Gram positive bacterial infections. Azlocillin For the treatment of infections caused by Pseudomonas aeruginosa, Escherichia coli, and Haemophilus influenzae. Iohexol A contrast agent for intrathecal administration used in myelography and contrast enhancement for computerized tomography.
- Drugs & Drug Targets