Pulmonary Arterial Hypertension (PAH)

Also known as: Hypertension, Pulmonary Artery / Pulmonary arterial hypertension

DrugDrug NameDrug Description
DB01240EpoprostenolA vasodilator and platelet aggregation inhibitor used for the management of primary pulmonary hypertension and pulmonary hypertension in patients with heart failure.
DB08931RiociguatA stimulator of soluble guanylate cyclase indicated for the management of persistent or recurrent chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension.
DB00203SildenafilA phosphodiesterase inhibitor used for the treatment of erectile dysfunction.
DB00820TadalafilA phosphodiesterase 5 inhibitor used to treat erectile dysfunction, benign prostatic hyperplasia, and pulmonary arterial hypertension.
DrugDrug NameTargetType
DB01240EpoprostenolP2Y purinoceptor 12target
DB01240EpoprostenolProstacyclin receptortarget
DB01240EpoprostenolProstacyclin synthasetarget
DB08931RiociguatSerum albumincarrier
DB08931RiociguatAlpha-1-acid glycoprotein 1carrier
DB08931RiociguatGuanylate cyclase soluble subunit alpha-2target
DB08931RiociguatATP-binding cassette sub-family G member 2transporter
DB08931RiociguatCytochrome P450 1A1enzyme
DB08931RiociguatCytochrome P450 3A4enzyme
DB08931RiociguatCytochrome P450 2C8enzyme
DB08931RiociguatCytochrome P450 2J2enzyme
DB00203SildenafilcGMP-specific 3',5'-cyclic phosphodiesterasetarget
DB00203SildenafilCytochrome P450 2C9enzyme
DB00203SildenafilRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gammatarget
DB00203SildenafilRetinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gammatarget
DB00203SildenafilCytochrome P450 3A4enzyme
DB00203SildenafilCytochrome P450 3A5enzyme
DB00203SildenafilCytochrome P450 3A7enzyme
DB00203SildenafilMultidrug resistance-associated protein 4transporter
DB00203SildenafilMultidrug resistance-associated protein 5transporter
DB00203SildenafilMultidrug resistance-associated protein 7transporter
DB00203SildenafilCytochrome P450 2C19enzyme
DB00203SildenafilCytochrome P450 2D6enzyme
DB00203SildenafilCytochrome P450 2E1enzyme
DB00203SildenafilSolute carrier organic anion transporter family member 1B1transporter
DB00203SildenafilP-glycoprotein 1transporter
DB00820TadalafilcGMP-specific 3',5'-cyclic phosphodiesterasetarget
DB00820TadalafilCytochrome P450 3A4enzyme
DB00820TadalafilDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11Atarget
DB00820TadalafilCytochrome P450 3A5enzyme
DrugDrug NamePhaseStatusCount
DB12000Apabetalone0Recruiting1
DB00559Bosentan0Completed1
DB09074Olaparib0Terminated1
DB00503Ritonavir0Unknown Status1
DB01232Saquinavir0Unknown Status1
DB06268Sitaxentan0Completed1
DB03128Acetylcholine1Recruiting1
DB00026Anakinra1Completed1
DB11842Angiotensin II1Recruiting1
DB00126Ascorbic acid1Recruiting1
DB12054BQ-1231Recruiting1
DB00559Bosentan1Completed1
DB15744CAP-10021Recruiting1
DB05161Elafin1Active Not Recruiting1
DB12039Epicatechin1Withdrawn1
DB00736Esomeprazole1Completed1
DB00950Fexofenadine1Recruiting1
DB00281Lidocaine1Withdrawn1
DB00166Lipoic acid1Recruiting1
DB05063Mitoquinone1Recruiting1
DB00218Moxifloxacin1Completed1
DB00325Nitroprusside1Recruiting1
DB09112Nitrous acid1Completed2
DB00368Norepinephrine1Recruiting1
DB00692Phentolamine1Recruiting1
DB15730Placental Mesenchymal Stem Cells1Terminated1
DB00863Ranitidine1Recruiting1
DB00243Ranolazine1Completed1
DB00206Reserpine1Withdrawn1
DB01045Rifampicin1Withdrawn1
DB00503Ritonavir1Withdrawn1
DB00360Sapropterin1Completed1
DB00203Sildenafil1Terminated1
DB06268Sitaxentan1Terminated1
DB06268Sitaxentan1Withdrawn2
DB00398Sorafenib1Completed1
DB00820Tadalafil1Terminated1
DB11815Tilarginine1Recruiting1
DB00374Treprostinil1Completed7
DB00374Treprostinil1Recruiting2
DB00163Vitamin E1Recruiting1
DB12389Zamicastat1Completed2
DB06403Ambrisentan1 / 2Recruiting1
DB01136Carvedilol1 / 2Completed1
DB01136Carvedilol1 / 2Withdrawn1
DB01088Iloprost1 / 2Completed1
DB09074Olaparib1 / 2Recruiting1
DB00795Sulfasalazine1 / 2Recruiting1
DB00820Tadalafil1 / 2Completed1
DB15111Acetic acid C-112Terminated1
DB01217Anastrozole2Completed1
DB01217Anastrozole2Recruiting1
DB05983Bardoxolone methyl2Completed1
DB05229Beraprost2Completed1
DB00559Bosentan2Unknown Status1
DB15026CXA-102Active Not Recruiting1
DB06774Capsaicin2Completed1
DB01136Carvedilol2Terminated1
DB12766Cicletanine2Terminated1
DB01240Epoprostenol2Active Not Recruiting1
DB00927Famotidine2Recruiting1
DB00472Fluoxetine2Completed2
DB00947Fulvestrant2Completed1
DB00743Gadobenic acid2Terminated1
DB01088Iloprost2Withdrawn1
DB00619Imatinib2Not Yet Recruiting1
DB01592Iron2Completed1
DB00893Iron Dextran2Completed1
DB15763Iron polymaltose2Completed1
DB08932Macitentan2Unknown Status1
DB00331Metformin2Recruiting1
DB00331Metformin2Withdrawn1
DB00295Morphine2Unknown Status1
DB04868Nilotinib2Terminated1
DB00435Nitric Oxide2Completed5
DB12529Nitrite2Terminated1
DB09112Nitrous acid2Terminated2
DB09140Oxygen2Recruiting1
DB01708Prasterone2Recruiting1
DB12462Ralinepag2Active Not Recruiting1
DB12462Ralinepag2Completed1
DB11362Selexipag2Recruiting1
DB14916Selonsertib2Completed1
DB00641Simvastatin2Unknown Status1
DB12118Sotatercept2Active Not Recruiting1
DB12118Sotatercept2Recruiting1
DB00421Spironolactone2Recruiting1
DB00864Tacrolimus2Completed1
DB00820Tadalafil2Recruiting1
DB00675Tamoxifen2Recruiting1
DB06558Tezosentan2Terminated2
DB06273Tocilizumab2Completed1
DB00374Treprostinil2Active Not Recruiting1
DB00374Treprostinil2Completed2
DB00374Treprostinil2Withdrawn1
DB09069Trimetazidine2Unknown Status1
DB03424Ubenimex2Completed1
DB03424Ubenimex2Terminated1
DB06267Udenafil2Completed1
DB00862Vardenafil2Recruiting1
DB12389Zamicastat2Recruiting1
DB00559Bosentan2 / 3Completed1
DB00619Imatinib2 / 3Completed1
DB00203Sildenafil2 / 3Unknown Status1
DB06267Udenafil2 / 3Completed1
DB06403Ambrisentan3Completed4
DB00559Bosentan3Completed4
DB00559Bosentan3Unknown Status1
DB01240Epoprostenol3Completed2
DB01088Iloprost3Completed2
DB01088Iloprost3Terminated1
DB01088Iloprost3Unknown Status1
DB00619Imatinib3Completed2
DB00619Imatinib3Terminated2
DB00332Ipratropium3Withdrawn1
DB08932Macitentan3Active Not Recruiting1
DB08932Macitentan3Completed5
DB08932Macitentan3Enrolling by Invitation1
DB08932Macitentan3Recruiting2
DB08932Macitentan3Terminated3
DB00435Nitric Oxide3Active Not Recruiting1
DB00435Nitric Oxide3Terminated1
DB00435Nitric Oxide3Withdrawn2
DB12462Ralinepag3Enrolling by Invitation1
DB12462Ralinepag3Not Yet Recruiting1
DB12462Ralinepag3Recruiting1
DB00243Ranolazine3Completed1
DB08931Riociguat3Recruiting1
DB01001Salbutamol3Withdrawn1
DB11362Selexipag3Active Not Recruiting1
DB11362Selexipag3Completed4
DB00203Sildenafil3Completed1
DB00203Sildenafil3Terminated3
DB06268Sitaxentan3Terminated4
DB12118Sotatercept3Not Yet Recruiting1
DB00820Tadalafil3Completed1
DB00374Treprostinil3Active Not Recruiting2
DB00374Treprostinil3Completed2
DB00374Treprostinil3Recruiting1
DB00374Treprostinil3Withdrawn3
DB06403Ambrisentan4Completed3
DB06403Ambrisentan4Terminated2
DB00559Bosentan4Completed4
DB00559Bosentan4Unknown Status1
DB00559Bosentan4Withdrawn1
DB01240Epoprostenol4Completed2
DB01088Iloprost4Completed1
DB00281Lidocaine4Terminated1
DB08932Macitentan4Completed1
DB08932Macitentan4Terminated1
DB08932Macitentan4Unknown Status1
DB08931Riociguat4Completed1
DB11362Selexipag4Completed1
DB11362Selexipag4Not Yet Recruiting1
DB00203Sildenafil4Active Not Recruiting1
DB00203Sildenafil4Completed6
DB00203Sildenafil4Recruiting1
DB00203Sildenafil4Terminated1
DB00203Sildenafil4Unknown Status2
DB00203Sildenafil4Withdrawn1
DB00421Spironolactone4Suspended1
DB00421Spironolactone4Terminated1
DB00820Tadalafil4Completed3
DB00820Tadalafil4Terminated2
DB00820Tadalafil4Unknown Status2
DB00374Treprostinil4Completed5
DB00374Treprostinil4Recruiting1
DB00374Treprostinil4Terminated2
DB00374Treprostinil4Withdrawn3
DB00862Vardenafil4Unknown Status2
DB01418AcenocoumarolNot AvailableRecruiting1
DB00945Acetylsalicylic acidNot AvailableRecruiting1
DB00802AlfentanilNot AvailableCompleted1
DB06403AmbrisentanNot AvailableCompleted1
DB06403AmbrisentanNot AvailableUnknown Status1
DB00479AmikacinNot AvailableCompleted1
DB00513Aminocaproic acidNot AvailableCompleted1
DB00513Aminocaproic acidNot AvailableRecruiting1
DB01118AmiodaroneNot AvailableRecruiting1
DB00182AmphetamineNot AvailableRecruiting1
DB00026AnakinraNot AvailableRecruiting1
DB00207AzithromycinNot AvailableRecruiting1
DB00559BosentanNot AvailableCompleted5
DB00559BosentanNot AvailableRecruiting1
DB00559BosentanNot AvailableUnknown Status1
DB01222BudesonideNot AvailableRecruiting1
DB06168CanakinumabNot AvailableRecruiting1
DB00535CefdinirNot AvailableRecruiting1
DB01413CefepimeNot AvailableCompleted1
DB01413CefepimeNot AvailableRecruiting1
DB00438CeftazidimeNot AvailableRecruiting1
DB00369CidofovirNot AvailableCompleted1
DB00537CiprofloxacinNot AvailableCompleted1
DB01190ClindamycinNot AvailableRecruiting1
DB00349ClobazamNot AvailableRecruiting1
DB00363ClozapineNot AvailableCompleted1
DB01394ColchicineNot AvailableRecruiting1
DB01234DexamethasoneNot AvailableRecruiting1
DB00633DexmedetomidineNot AvailableRecruiting1
DB00343DiltiazemNot AvailableWithdrawn1
DB01240EpoprostenolNot AvailableCompleted2
DB01240EpoprostenolNot AvailableTerminated1
DB08917Ferric carboxymaltoseNot AvailableCompleted1
DB13136FluindioneNot AvailableRecruiting1
DB00828FosfomycinNot AvailableCompleted1
DB00828FosfomycinNot AvailableRecruiting1
DB00695FurosemideNot AvailableRecruiting1
DB00996GabapentinNot AvailableRecruiting1
DB01018GuanfacineNot AvailableRecruiting1
DB00502HaloperidolNot AvailableCompleted1
DB00741HydrocortisoneNot AvailableRecruiting1
DB01088IloprostNot AvailableCompleted6
DB01088IloprostNot AvailableTerminated2
DB15763Iron polymaltoseNot AvailableCompleted1
DB00598LabetalolNot AvailableCompleted1
DB00598LabetalolNot AvailableRecruiting1
DB01601LopinavirNot AvailableRecruiting1
DB08815LurasidoneNot AvailableCompleted1
DB08932MacitentanNot AvailableCompleted2
DB09337Medical airNot AvailableUnknown Status1
DB00760MeropenemNot AvailableRecruiting1
DB00331MetforminNot AvailableRecruiting1
DB00959MethylprednisoloneNot AvailableCompleted1
DB00235MilrinoneNot AvailableRecruiting1
DB01618MolindoneNot AvailableCompleted1
DB00607NafcillinNot AvailableCompleted1
DB00844NalbuphineNot AvailableRecruiting1
DB00622NicardipineNot AvailableRecruiting1
DB01115NifedipineNot AvailableCompleted1
DB01115NifedipineNot AvailableRecruiting1
DB00198OseltamivirNot AvailableRecruiting1
DB00497OxycodoneNot AvailableCompleted1
DB00497OxycodoneNot AvailableRecruiting1
DB00312PentobarbitalNot AvailableCompleted1
DB00319PiperacillinNot AvailableCompleted1
DB14761RemdesivirNot AvailableRecruiting1
DB00811RibavirinNot AvailableRecruiting1
DB00734RisperidoneNot AvailableRecruiting1
DB00503RitonavirNot AvailableRecruiting1
DB00728RocuroniumNot AvailableCompleted1
DB08877RuxolitinibNot AvailableRecruiting1
DB11767SarilumabNot AvailableRecruiting1
DB11362SelexipagNot AvailableCompleted1
DB01104SertralineNot AvailableRecruiting1
DB00658SevelamerNot AvailableCompleted1
DB00658SevelamerNot AvailableRecruiting1
DB00203SildenafilNot AvailableCompleted4
DB00203SildenafilNot AvailableNo Longer Available4
DB00203SildenafilNot AvailableRecruiting1
DB06268SitaxentanNot AvailableCompleted1
DB06268SitaxentanNot AvailableTerminated1
DB06268SitaxentanNot AvailableUnknown Status1
DB00421SpironolactoneNot AvailableCompleted1
DB00421SpironolactoneNot AvailableRecruiting1
DB00820TadalafilNot AvailableCompleted2
DB01606TazobactamNot AvailableCompleted1
DB00871TerbutalineNot AvailableRecruiting1
DB00684TobramycinNot AvailableCompleted1
DB06273TocilizumabNot AvailableRecruiting1
DB00302Tranexamic acidNot AvailableCompleted1
DB00302Tranexamic acidNot AvailableRecruiting1
DB00374TreprostinilNot AvailableCompleted2
DB00374TreprostinilNot AvailableNot Yet Recruiting2
DB00374TreprostinilNot AvailableRecruiting1
DB00512VancomycinNot AvailableCompleted1
DB01339VecuroniumNot AvailableCompleted1
DB00582VoriconazoleNot AvailableRecruiting1
DB00682WarfarinNot AvailableCompleted1
DB00682WarfarinNot AvailableRecruiting1
DB00246ZiprasidoneNot AvailableCompleted1
DB00425ZolpidemNot AvailableCompleted1
DB00425ZolpidemNot AvailableRecruiting1