Cyclohexanes

Name
Cyclohexanes
Accession Number
DBCAT000358
Description

Six-carbon alicyclic hydrocarbons.

Drugs
DrugDrug Description
Vitamin AA vitamin important for retinal function that is used clinically to correct vitamin A deficiency.
TramadolA centrally-acting opioid agonist and SNRI (serotonin/norepinephrine reuptake inhibitor) used for the management of moderate to severe pain in adults.
VenlafaxineA selective serotonin and norepinephrine reuptake inhibitor (SNRI) used for the treatment of major depression.
Tranexamic acidAn antifibrinolytic agent used for heavy menstrual bleeding.
NitisinoneA hydroxyphenylpyruvate dioxygenase inhibitor used as an adjunct to dietary restrictions for the treatment of hereditary tyrosinemia type 1 (HT-1), which causes intolerance to tyrosine containing foods.
AcitretinAn oral retinoid used in the treatment of severe psoriasis.
PicrotoxinUsed internally for relieving respiratory distress. Also for use as an antidote in poisoning by CNS depressants, especially barbiturates.
HexylcaineUsed as a local anesthetic for surface application, infiltration or nerve block
AlitretinoinA vitamin A derivative used to treat Kaposi's sarcoma and used off label to treat chronic hand eczema and psoriasis.
AdenosineA medication used in myocardial perfusion scintigraphy.
TretinoinA vitamin A derivative used to treat acne vulgaris, certain types of promyelocytic leukemia, and fine wrinkles.
DicyclomineAn antimuscarinic agent used to treat IBS.
EtretinateFor the treatment of severe psoriasis in adults.
IsotretinoinA retinoid used to treat severe recalcitrant acne.
GabapentinAn anticonvulsant medication used in the management of peripheral neuropathic pains, postherpetic neuralgia, and partial-onset seizures.
KetamineA rapid-acting general anesthetic and NMDA receptor antagonist used for induction of anesthesia diagnostic and surgical procedures typically in combination with a muscle relaxant.
1-PhenylcyclohexylamineNot Available
GabaculineNot Available
CyclohexanoneCyclohexanone (also known as oxocyclohexane, pimelic ketone, ketohexamethylene, cyclohexyl ketone or ketocyclohexane) is a six-carbon cyclic molecule with a ketone functional group. It is a colorless, oily liquid with an...
4-OxoretinolNot Available
Isochorismic AcidNot Available
Arotinoid acidArotinoid acid is a retinoic acid analog which acts as a selective RAR agonist.
PeridininNot Available
ViolaxanthinNot Available
CyclohexanolMonohydroxy derivatives of cyclohexanes that contain the general formula R-C6H11O. They have a camphorlike odor and are used in making soaps, insecticides, germicides, dry cleaning, and plasticizers. [PubChem]
CilomilastInvestigated for use/treatment in chronic obstructive pulmonary disease (COPD).
EucalyptolA common ingredient in mouthwash and cosmetics derived naturally from the eucalyptus plant that is frequently used to to improve symptoms of airway mucus hypersecretion.
3-Dehydroquinic AcidNot Available
Shikimate-3-PhosphateNot Available
3-DehydroshikimateNot Available
VogliboseFor the treatment of diabetes. It is specifically used for lowering post-prandial blood glucose levels thereby reducing the risk of macrovascular complications.
ApadenosonInvestigated for use/treatment in cardiovascular disorders and inflammatory disorders (unspecified).
FenretinideInvestigated for use/treatment in macular degeneration.
Atl146eInvestigated for use/treatment in inflammatory disorders (unspecified).
IRX-5183Investigated for use/treatment in adverse effects (chemotherapy) and blood (blood forming organ disorders, unspecified).
TranscrocetinateInvestigated for use/treatment in cancer/tumors (unspecified), hemorrhage, hypoxia, respiratory failure, and strokes.
AstaxanthinInvestigated for use/treatment in eye disorders/infections, cancer/tumors (unspecified), and asthma.
DesvenlafaxineAn antidepressant agent and SNRI used for the treatment of major depressive disorders in adults.
AmbroxolAmbroxol is indicated for secretolytic therapy in bronchoplmonary diseaes with abnormal mucus secretion and transport. It allows the mucus to be more easily cleared and ease a patient's breathing.
Beta caroteneA vitamin A precursor found in various nutritional supplements and health products.
3-Fluoro-4-{[(2R)-2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)acetyl]amino}benzoic acidNot Available
Prephenic acidNot Available
Ro 12-7310Not Available
(4R)-limoneneLimonene is common in cosmetic products. As the main odor constituent of citrus (plant family Rutaceae), D-limonene is used in food manufacturing and some medicines, e.g. as a flavoring to...
BromhexineBromhexine is an expectorant/mucolytic agent. Bromhexine is not available in the United States. It is marketed under the trade name Bisolvon(R) in Germany, England, Belgium, France, Italy, Netherlands, Norway, Sweden,...
ZeaxanthinZeaxanthin is a most common carotenoid alcohols found in nature that is involved in the xanthophyll cycle. As a coexistent isomer of lutein, zeaxanthin is synthesized in plants and some...
LycopeneAn ingredient found in a variety of supplements and vitamins.
TiletamineThis drug is a dissociative anesthetic agent that falls under the drug category of NMDA receptor antagonists. Tiletamine is chemically similar to another dissociative anesthetic, ketamine. Tiletamine hydrochloride, the salt...
CandoxatrilatA dicarboxylic acid monoamide obtained by formal condensation between the amino group of cis-4-aminocyclohexanecarboxylic acid and the cyclopentanecarboxylic acid group of 1-[(2S)-2-carboxy-3-(2-methoxyethoxy)propyl]cyclopentanecarboxylic acid. A potent inhibitor of neutral endopeptidase (NEP,...
TanzisertibTanzisertib has been used in trials studying the treatment of Fibrosis, Discoid Lupus, Pulmonary Fibrosis, Interstitial Lung Disease, and Lung Diseases, Interstitial, among others.
CrocinCrocin has been investigated for the treatment of Hyperglycemia, Metabolic Syndrome, Hypertriglyceridemia, and Hypercholesterolemia.
LomibuvirLomibuvir has been used in trials studying the treatment of Chronic Hepatitis C Virus and Chronic Hepatitis C Virus Infection.
Chlorogenic AcidChlorogenic Acid has been used in trials studying the treatment of Advanced Cancer and Impaired Glucose Tolerance.
Zuretinol acetateZuretinol acetate has been used in trials studying the treatment of Impaired Dark Adaptation, RP (Retinitis Pigmentosa), Retinitis Pigmentosa (RP), and LCA (Leber Congenital Amaurosis).
MK-5108MK-5108 has been used in trials studying the treatment of Cancer, Neoplasms, Tumors.
AQX-1125AQX-1125 has been used in trials studying the treatment of COPD, Atopic Dermatitis, Interstitial Cystitis, and Bladder Pain Syndrome.
GacyclidineGacyclidine has been used in trials studying the treatment of Tinnitus.
Ambroxol acefyllinateNot Annotated
Terpin hydrateAn expectorant used to treat bronchitis, pneumonia, bronchiectasis, COPD, and infectious or inflammatory diseases of the upper respiratory tract.
NeltenexineNeltenexine is an elastase inhibitor. It may be useful for preventing pulmonary emphysema.
MotretinideNot Annotated
RociverineNot Annotated
TilidineNot Annotated
13-cis-12-(3'-Carboxyphenyl)retinoic acidNot Annotated
LuteinXanthophylls are taken for nutritional supplementation, and also for treating dietary shortage or imbalance.
Oseltamivir acidNot Available
NorbixinNorbixin is under investigation in clinical trial NCT03820245 (Effect of Short-term Annatto Carotenoids Supplementation on Oxidative Stress Status in Healthy Individuals).
FucoxanthinFucoxanthin is under investigation in clinical trial NCT03613740 (Effect of Fucoxanthin on the Components of the Metabolic Syndrome, Insulin Sensitivity and Insulin Secretion).
BexaroteneA retinoid drug used for cutaneous manifestations of T-cell lymphoma in patients who have not responded well to previous systemic therapy.
NateglinideA meglitinide used to treat non insulin dependent diabetes mellitus.
CiclopiroxA broad-spectrum topical antifungal agent used to treat mild to moderate onychomycosis of fingernails and toenails in immunocompetent patients.
MaravirocA CCR5 co-receptor antagonist used with other antiretroviral medications to treat CCR5-tropic HIV-1 infection.
TNP-470O-(chloroacetylcarbamoyl)fumagillol (TNP-470) has been used in trials studying the treatment of HIV Infections, Sarcoma, Kaposi, and Pancreatic Neoplasms.
EsketamineA NMDA receptor antagonist used for treatment-resistant depression.
LevomentholAn organic compound used to treat mild to moderate muscle and joint pain.
Anhydrovitamin ANot Available
3-(cyclohexylamino)propanesulfonic acidNot Available
N-EthylretinamideN-Ethylretinamide is the ethylamide of all-trans B-retinoic acid.
Drugs & Drug Targets
DrugTargetType
Vitamin ARetinol dehydrogenase 12target
Vitamin A11-cis retinol dehydrogenasetarget
Vitamin ARetinol dehydrogenase 13target
Vitamin ARetinol-binding protein 5carrier
Vitamin ARetinoid-binding protein 7carrier
Vitamin ARetinol-binding protein 4carrier
Vitamin ARetinol-binding protein 2carrier
Vitamin ARetinal dehydrogenase 2target
Vitamin ARetinal dehydrogenase 1target
Vitamin ALecithin retinol acyltransferasetarget
Vitamin AShort-chain dehydrogenase/reductase 3target
Vitamin AAldehyde dehydrogenase family 1 member A3target
Vitamin AAll-trans-retinol 13,14-reductasetarget
Vitamin ARetinol dehydrogenase 11target
Vitamin ADehydrogenase/reductase SDR family member 4target
Vitamin ARetinol dehydrogenase 14target
Vitamin ARetinol dehydrogenase 8target
Vitamin ACytochrome P450 26A1enzyme
Vitamin AApolipoprotein Dtarget
Vitamin AProstaglandin-H2 D-isomerasetarget
Vitamin ASerum albumincarrier
Vitamin ARetinaldehyde-binding protein 1carrier
Vitamin ARetinol-binding protein 3carrier
Vitamin ARetinol-binding protein 1carrier
Vitamin AReceptor for retinol uptake STRA6transporter
TramadolMu-type opioid receptortarget
TramadolSodium-dependent noradrenaline transportertarget
Tramadol5-hydroxytryptamine receptor 2Ctarget
TramadolKappa-type opioid receptortarget
TramadolSodium-dependent serotonin transportertarget
TramadolCytochrome P450 2D6enzyme
TramadolDelta-type opioid receptortarget
TramadolCytochrome P450 3A4enzyme
TramadolCytochrome P450 2B6enzyme
TramadolAlpha-7 nicotinic cholinergic receptor subunittarget
TramadolMuscarinic acetylcholine receptor M3target
TramadolMuscarinic acetylcholine receptor M1target
TramadolUDP-glucuronosyltransferase 1-1enzyme
TramadolNeurokinin 1 receptortarget
TramadolSodium channel protein type 2 subunit alphatarget
TramadolTransient receptor potential cation channel subfamily V member 1target
TramadolNMDA receptortarget
TramadolAdenosine receptor A1target
TramadolAlpha-2 adrenergic receptorstarget
VenlafaxineSodium-dependent serotonin transportertarget
VenlafaxineSodium-dependent noradrenaline transportertarget
VenlafaxineCytochrome P450 2D6enzyme
VenlafaxineCytochrome P450 3A4enzyme
VenlafaxineSodium-dependent dopamine transportertarget
VenlafaxineP-glycoprotein 1transporter
VenlafaxineATP-binding cassette sub-family G member 2transporter
Tranexamic acidPlasminogentarget
Tranexamic acidSolute carrier family 15 member 2transporter
Nitisinone4-hydroxyphenylpyruvate dioxygenasetarget
AcitretinRetinoic acid receptor alphatarget
AcitretinRetinoic acid receptor RXR-betatarget
AcitretinRetinoic acid receptor gammatarget
AcitretinRetinoic acid receptor betatarget
AcitretinRetinoic acid receptor RXR-gammatarget
AcitretinRetinoic acid receptor RXR-alphatarget
AcitretinSerum albumincarrier
AcitretinRetinol-binding protein 1target
AcitretinRetinoic acid receptor RXRtarget
PicrotoxinGamma-aminobutyric acid receptor subunit rho-1target
PicrotoxinGamma-aminobutyric acid receptor subunit alpha-1target
PicrotoxinGlycine receptor subunit alpha-2target
PicrotoxinGlycine receptor subunit alpha-3target
PicrotoxinCytochrome P450 1A1enzyme
PicrotoxinGlutamine synthetaseenzyme
PicrotoxinGlycine receptor subunit alpha-1target
HexylcaineSodium channel protein type 5 subunit alphatarget
HexylcaineSodium channel protein type 10 subunit alphatarget
AlitretinoinRetinoic acid receptor alphatarget
AlitretinoinRetinoic acid receptor RXR-betatarget
AlitretinoinRetinoic acid receptor gammatarget
AlitretinoinRetinoic acid receptor betatarget
AlitretinoinRetinoic acid receptor RXR-gammatarget
AlitretinoinRetinoic acid receptor RXR-alphatarget
AlitretinoinCellular retinoic acid-binding protein 2carrier
AlitretinoinCellular retinoic acid-binding protein 1carrier
AlitretinoinP-glycoprotein 1transporter
AlitretinoinInsulin-like growth factor-binding protein 3target
AlitretinoinPregnancy-specific beta-1-glycoprotein 5target
AlitretinoinCytochrome P450 26C1target
AdenosineAdenosine receptor A3target
AdenosineAdenosine deaminaseenzyme
AdenosineAdenosine kinaseenzyme
AdenosineAdenosine receptor A1target
AdenosineAdenosine receptor A2atarget
AdenosineAdenosine receptor A2btarget
AdenosineSolute carrier family 28 member 3transporter
TretinoinRetinoic acid receptor gammatarget
TretinoinRetinoic acid receptor RXR-betatarget
TretinoinRetinal dehydrogenase 1target
TretinoinRetinoic acid-induced protein 3target
TretinoinRetinoic acid receptor RXR-gammatarget
TretinoinRetinal dehydrogenase 2target
TretinoinRetinoic acid receptor responder protein 1target
TretinoinCytochrome P450 2C8enzyme
TretinoinCellular retinoic acid-binding protein 1transporter
TretinoinCellular retinoic acid-binding protein 2transporter
TretinoinCytochrome P450 2B6enzyme
TretinoinCytochrome P450 3A4enzyme
TretinoinCytochrome P450 3A5enzyme
TretinoinCytochrome P450 2A6enzyme
TretinoinCytochrome P450 3A7enzyme
TretinoinCytochrome P450 2C18enzyme
TretinoinCytochrome P450 2C9enzyme
TretinoinCytochrome P450 4A11enzyme
TretinoinCytochrome P450 1A1enzyme
TretinoinRetinoic acid receptor alphatarget
TretinoinRetinoic acid receptor betatarget
TretinoinLipocalin-1target
TretinoinOdorant-binding protein 2atarget
TretinoinRetinol-binding protein 4target
TretinoinSerum albumincarrier
Tretinoin[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrialtarget
TretinoinRetinoic acid receptor RXR-alphatarget
TretinoinCytochrome P450 26A1target
TretinoinCytochrome P450 26B1target
TretinoinCytochrome P450 26C1target
TretinoinHematopoietic prostaglandin D synthasetarget
DicyclomineMuscarinic acetylcholine receptor M1target
DicyclomineMuscarinic acetylcholine receptor M2target
EtretinateRetinoic acid receptor alphatarget
EtretinateRetinoic acid receptor RXR-betatarget
EtretinateRetinoic acid receptor gammatarget
EtretinateRetinoic acid receptor betatarget
EtretinateRetinoic acid receptor RXR-gammatarget
EtretinateRetinoic acid receptor RXR-alphatarget
EtretinateCellular retinoic acid-binding protein 1carrier
EtretinateCytochrome P450 19A1enzyme
IsotretinoinRetinoic acid receptor alphatarget
IsotretinoinSerum albumincarrier
IsotretinoinRetinoic acid receptor gammatarget
IsotretinoinCytochrome P450 3A4enzyme
GabapentinAdenosine receptor A1target
GabapentinVoltage-dependent calcium channel subunit alpha-2/delta-1target
GabapentinVoltage-dependent calcium channel subunit alpha-2/delta-2target
GabapentinBranched-chain-amino-acid aminotransferase, cytosolicenzyme
GabapentinLarge neutral amino acids transporter small subunit 1transporter
GabapentinVoltage-dependent N-type calcium channeltarget
GabapentinPotassium voltage-gated channel subfamily KQT member 3target
GabapentinPotassium voltage-gated channel subfamily KQT member 5target
KetamineGlutamate receptor ionotropic, NMDA 3Atarget
KetamineNeurokinin 1 receptortarget
KetamineCytochrome P450 2B6enzyme
KetamineCytochrome P450 2C9enzyme
KetamineCytochrome P450 3A4enzyme
KetamineDopamine D2 receptortarget
KetamineProstaglandin G/H synthase 1enzyme
KetamineCytochrome P450 2C8enzyme
KetamineDelta-type opioid receptortarget
KetamineSodium-dependent noradrenaline transportertarget
KetamineKappa-type opioid receptortarget
KetamineMu-type opioid receptortarget
KetamineMuscarinic acetylcholine receptortarget
Ketamine5-hydroxytryptamine receptor 2target
Ketamine5-hydroxytryptamine receptor 1target
Ketamine5-hydroxytryptamine receptor 3Atarget
KetamineAlpha-7 nicotinic cholinergic receptor subunittarget
KetamineCholinesterasetarget
KetamineNitric oxide synthase, braintarget
GabaculineOrnithine aminotransferase, mitochondrialtarget
GabaculineGlutamate-1-semialdehyde 2,1-aminomutasetarget
CyclohexanonePentaerythritol tetranitrate reductasetarget
Isochorismic AcidPhenazine biosynthesis protein PhzDtarget
Arotinoid acidRetinoic acid receptor betatarget
CyclohexanolAlcohol dehydrogenase 1Btarget
CilomilastcAMP-specific 3',5'-cyclic phosphodiesterase 4Dtarget
CilomilastcAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
3-Dehydroquinic Acid3-dehydroquinate dehydratasetarget
Shikimate-3-Phosphate3-phosphoshikimate 1-carboxyvinyltransferasetarget
Shikimate-3-Phosphate3-phosphoshikimate 1-carboxyvinyltransferasetarget
3-Dehydroshikimate3-dehydroquinate dehydratasetarget
3-Dehydroshikimate3-dehydroquinate dehydratasetarget
VogliboseMaltase-glucoamylase, intestinaltarget
ApadenosonAdenosine receptor A2atarget
FenretinideRetinol-binding protein 4carrier
Atl146eAdenosine receptor A2atarget
AstaxanthinNF-kappa-B inhibitor alphatarget
DesvenlafaxineCytochrome P450 3A4enzyme
DesvenlafaxineSodium-dependent serotonin transportertarget
DesvenlafaxineSodium-dependent noradrenaline transportertarget
DesvenlafaxineCytochrome P450 2D6enzyme
DesvenlafaxineSodium-dependent dopamine transportertarget
AmbroxolCytochrome P450 3A4enzyme
Beta caroteneBeta,beta-carotene 15,15'-dioxygenaseenzyme
Beta caroteneFree radicalstarget
Beta caroteneVery low-density lipoprotein receptorcarrier
Beta caroteneRetinol-binding protein 1carrier
Beta caroteneRetinol-binding protein 2carrier
Beta caroteneRetinol-binding protein 3carrier
Beta caroteneRetinol-binding protein 4carrier
Beta caroteneRetinol-binding protein 5carrier
3-Fluoro-4-{[(2R)-2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)acetyl]amino}benzoic acidRetinoic acid receptor gammatarget
Prephenic acidChorismate mutase AroHtarget
Ro 12-7310Cellular retinoic acid-binding protein 2carrier
CandoxatrilatNeprilysintarget
Ambroxol acefyllinateCytochrome P450 3A Subfamilyenzyme
RociverineMuscarinic acetylcholine receptor M1target
RociverineMuscarinic acetylcholine receptor M2target
RociverineMuscarinic acetylcholine receptor M3target
RociverineMuscarinic acetylcholine receptor M4target
RociverineMuscarinic acetylcholine receptor M5target
LuteinSerum albumincarrier
Oseltamivir acidNeuraminidasetarget
BexaroteneRetinoic acid receptor RXR-betatarget
BexaroteneCytochrome P450 3A4enzyme
BexaroteneRetinoic acid receptor RXR-alphatarget
BexaroteneRetinoic acid receptor RXR-gammatarget
BexaroteneCytochrome P450 2C8enzyme
NateglinideATP-binding cassette sub-family C member 8target
NateglinideCytochrome P450 3A4enzyme
NateglinideCytochrome P450 2C9enzyme
NateglinidePeroxisome proliferator-activated receptor gammatarget
NateglinideCytochrome P450 3A5enzyme
NateglinideCytochrome P450 3A7enzyme
NateglinideSolute carrier family 15 member 1transporter
NateglinideSolute carrier family 15 member 2transporter
NateglinideSolute carrier family 22 member 6transporter
NateglinideMonocarboxylate transporter 1transporter
NateglinideProstaglandin G/H synthase 1enzyme
NateglinideUDP-glucuronosyltransferase 1-9enzyme
NateglinideCytochrome P450 2D6enzyme
NateglinideMultidrug resistance-associated protein 4transporter
NateglinideSerum albumincarrier
NateglinideAlpha-1-acid glycoprotein 1carrier
CiclopiroxSodium/potassium-transporting ATPase subunit alpha-1target
MaravirocC-C chemokine receptor type 5target
MaravirocCytochrome P450 3A4enzyme
TNP-470Methionine aminopeptidase 2target
EsketamineNMDA receptortarget
EsketamineCytochrome P450 2B6enzyme
EsketamineCytochrome P450 3A4enzyme
EsketamineCytochrome P450 2C19enzyme
EsketamineCytochrome P450 2C9enzyme
EsketamineGlutamate receptor ionotropic, NMDA 2Btarget
EsketamineElongation factor 2target
EsketamineBrain-derived neurotrophic factortarget
EsketamineBDNF/NT-3 growth factors receptortarget
LevomentholTransient receptor potential cation channel subfamily A member 1target
LevomentholTransient receptor potential cation channel subfamily M member 8target
LevomentholTransient receptor potential cation channel subfamily V member 3target
LevomentholKappa-type opioid receptortarget
LevomentholVoltage-dependent L-type calcium channeltarget
LevomentholCytochrome P450 3A4enzyme
N-EthylretinamideRetinol-binding protein 4carrier