Dolastatin 10

DB12730InvestigationalSmall molecule

Dolastatin 10 has been used in trials studying the treatment of Sarcoma, Leukemia, Lymphoma, Liver Cancer, and Kidney Cancer, among others.

Chemical structure of Dolastatin 10
Formula / weight
C42H68N6O6S · 785.1 g/mol (avg)
Code names
NSC-376128

Resolves to

Compound
UNIIEI946JT51XCAS110417-88-4ChEMBLCHEMBL39541ChEBI67357PubChem9810929
Structure
InChIKeyOFDNQWIFNXBECV-VFSYNPLYSA-NSMILESCC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@@H](CC1=CC=CC=C1)C1=NC=CS1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C)C(C)C
Targets
Q13885TUBB2A

What you can answer from here — as of January 29, 2025

1Protein targetEach mapped to UniProt, with action and pharmacological action
Listed above
39Drug interactionsStructured to mechanism, not free text
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7Clinical trialsPhase, status and sponsor resolved per trial
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1+ReferenceStructured and connected to the statements they support
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Which drugs share a target with Dolastatin 10, and which of those have an active Phase 3 trial?

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