Peptides, Cyclic

Peptides, Cyclic
Accession Number

Peptides whose amino and carboxy ends are linked together with a peptide bond forming a circular chain. Some of them are ANTI-INFECTIVE AGENTS. Some of them are biosynthesized non-ribosomally (PEPTIDE BIOSYNTHESIS, NON-RIBOSOMAL).

DrugDrug Description
Gramicidin DA bactericidal antibiotic used in the treatment of dermatological and ophthalmic infections.
DaptomycinA cyclic lipopeptide antibiotic used to treat complicated skin and skin structure infections by susceptible Gram-positive bacteria and bacteremia due to Staphylococcus aureus.
CyclosporineA steroid-sparing immunosuppressant used in organ and bone marrow transplants as well as inflammatory conditions such as ulcerative colitis, rheumatoid arthritis, and atopic dermatitis.
OctreotideA peptide drug used to treat acromegaly as well as diarrhea associated with metastatic carcinoid tumors and vasoactive intestinal peptide secreting tumors.
CapreomycinAn aminoglycoside antibiotic used as an adjunct drug in tuberculosis.
AnidulafunginAn antifungal used in the treatment of several types of candida infections.
CaspofunginAn echinocandin used to treat a variety of fungal infections.
BacitracinA cyclic polypeptide antibiotic used to prevent wound infections, treat pneumonia and empyema in infants, and to treat skin and eye infections.
ColistinA polymyxin antibiotic used to treat bacterial infections caused by susceptible Gram negative bacteria.
DactinomycinAn actinomycin used to treat a wide variety of cancers.
ColistimethateAn antibiotic indicated for treatment of infections caused by susceptible strains of certain gram-negative bacilli. It is particularly useful for targeting sensitive strains of Pseudomonas aeruginosa.
MicafunginAn antifungal agent used for the treatment of candidemia, acute disseminated candidiasis, and certain other invasive Candida infections, and for the prophylaxis of Candida infections during stem cell transplantation.
QuinupristinAn antibiotic agent used in the treatment of serious vancomycin-resistant Enterococcus faecium bacteremia as well as complicated skin and skin structure infections.
Virginiamycin M1For the treatment of bacterial infections.
DalfopristinAn antibiotic used with quinupristin to treat severe or life-threatening infections of vancomycin-resistant Enterococcus faecium (VREF), and skin infections caused by methicillin susceptible staphylococcus aureus or streptococcus pyogenes.
GallichromeNot Available
Virginiamycin S1One of the components of virginiamycin, a cyclic polypeptide antibiotic complex from streptomyces virginiae, s. Loidensis, s. Mitakaensis, s. Pristina-spiralis, s. Ostreogriseus, and others. It is used to treat infections...
RamoplaninFor the treatment of bacterial infections.
PlitidepsinIntended for the treatment of various forms of cancer.
PM02734Investigated for use/treatment in cancer/tumors (unspecified) and solid tumors.
RomidepsinA histone deacetylase (HDAC) inhibitor used to treat cutaneous and peripheral T-cell lymphoma.
ViomycinViomycin is an essential component in the drug cocktail currently used to fight infections of Mycobacterium tuberculosis.
EnviomycinCyclic basic peptide related to viomycin. It is isolated from an induced mutant of Streptomyces griseoverticillatus var. tuberacticus and acts as an antitubercular agent with less ototoxicity than tuberactinomycin.
EmodepsideEmodepside is an anthelmintic drug that is effective against a number of gastrointestinal nematodes, is licensed for use in cats and belongs to the class of drugs known as the...
ThiostreptonThiostrepton is a natural cyclic oligopeptide antibiotic, derived from several strains of streptomycetes including Streptomyces azureus and Streptomyces laurentii. Thiostrepton is a natural product of the ribosomally synthesized and post-translationally...
VirginiamycinVirginiamycin is a streptogramin antibiotic similar to pristinamycin and quinupristin/dalfopristin. It is a combination of pristinamycin IIA and virginiamycin S1. Virginiamycin is used in the fuel ethanol industry to prevent...
ValspodarValspodar has been used in trials studying the treatment of Cancer, Sarcoma, Leukemia, Lymphoma, and Breast Cancer, among others.
AlisporivirAlisporivir has been used in trials studying the treatment of Hepatitis C and Chronic Hepatitis C.
SCY-635SCY-635 has been investigated for the treatment of Chronic Hepatitis C and Hepatitis C Infection.
PentetreotideA somatostatin receptor inhibitor, available in a kit with Indium-111, used as a contrast agent in the visualization of somatostatin receptor-positive neuroendocrine tumours.
Dolastatin 10Dolastatin 10 has been used in trials studying the treatment of Sarcoma, Leukemia, Lymphoma, Liver Cancer, and Kidney Cancer, among others.
9-(N-methyl-L-isoleucine)-cyclosporin A9-(N-methyl-L-isoleucine)-cyclosporin A (NIM811) has been used in trials studying the treatment of Chronic Hepatitis C Genotype-1 Relapse.
TyrothricinA topical antibiotic with broad spectrum activity against Gram positive bacteria and some fungal infections.
PristinamycinNot Annotated
Lutetium Lu 177 dotatateA radiolabeled somatostatin analog used to treat somatostatin receptor positive gastroenteropancreatic neuroendocrine tumors.
ValinomycinA cyclododecadepsipeptide ionophore antibiotic produced by Streptomyces fulvissimus and related to the enniatins. It is composed of 3 moles each of L-valine, D-alpha-hydroxyisovaleric acid, D-valine, and L-lactic acid linked alternately...
BasifunginBasifungin, also known as aureuobacidin A, is a phosphorylceramide synthase inhibitor , .
VoclosporinA calcineurin inhibitor for the treatment of lupus nephritis (LN) in patients diagnosed with systemic lupus erythematosus (SLE).
Polymyxin BA polymyxin antibiotic used to treat a wide variety of infections in the body.
EptifibatideA peptide-based antagonist for glycoprotein IIb/IIIa used in the medical management of myocardial infarction and as an adjunct to percutaneous coronary intervention.
FusafungineFusafungine is an antibiotic from Fusarium lateririum, and is used for the treatment of respiratory infections.
Dotatate gallium Ga-68Dotatate gallium 68 is one of the most prominent radiopharmaceuticals used in imaging with positron emission tomography. It binds to the somatostatin-2 receptor which is usually overexpressed in many neuroendocrine...
EchinomycinEchinomycin is a cytotoxic polypeptide quinoxaline antibiotic isolated from Streptomyces echinatus that binds to DNA and inhibits RNA synthesis.
Copper oxodotreotide Cu-64A Cu labeled somatostatin analog used in positron emission tomography to detect certain types of neuroendocrine tumors.
RezafunginRezafungin is under investigation in clinical trial NCT04368559 (Study of Rezafungin Compared to Standard Antimicrobial Regimen for Prevention of Invasive Fungal Diseases in Adults Undergoing Allogeneic Blood and Marrow Transplantation).
Drugs & Drug Targets
Gramicidin DP-glycoprotein 1transporter
DaptomycinCytoplasmic membranetarget
DaptomycinSerum albumincarrier
DaptomycinAlpha-1-acid glycoprotein 1carrier
DaptomycinLow-density lipoprotein receptorcarrier
DaptomycinSex hormone-binding globulincarrier
DaptomycinP-glycoprotein 1transporter
CyclosporineCalcium signal-modulating cyclophilin ligandtarget
CyclosporinePeptidyl-prolyl cis-trans isomerase Atarget
CyclosporineCalcineurin subunit B type 2target
CyclosporineCytochrome P450 3A5enzyme
CyclosporineCytochrome P450 3A4enzyme
CyclosporineP-glycoprotein 1transporter
CyclosporineBile salt export pumptransporter
CyclosporineIleal sodium/bile acid cotransportertransporter
CyclosporineSodium/bile acid cotransportertransporter
CyclosporineSolute carrier family 22 member 6transporter
CyclosporineMultidrug resistance-associated protein 7transporter
CyclosporineCanalicular multispecific organic anion transporter 1transporter
CyclosporineATP-binding cassette sub-family G member 2transporter
CyclosporineSolute carrier organic anion transporter family member 1B1transporter
CyclosporineCytochrome P450 2C19enzyme
CyclosporineCytochrome P450 2D6enzyme
CyclosporinePeptidyl-prolyl cis-trans isomerase F, mitochondrialtarget
CyclosporineSolute carrier organic anion transporter family member 1B3transporter
OctreotideCytochrome P450 3A4enzyme
OctreotideSomatostatin receptortarget
OctreotideSerum albumincarrier
OctreotideP-glycoprotein 1transporter
OctreotideCanalicular multispecific organic anion transporter 1transporter
Capreomycin16S/23S rRNA (cytidine-2'-O)-methyltransferase TlyAtarget
Anidulafungin1,3-beta-glucan synthase component FKS1target
CaspofunginSolute carrier family 22 member 1transporter
CaspofunginP-glycoprotein 1transporter
CaspofunginSolute carrier family 22 member 6transporter
CaspofunginSolute carrier organic anion transporter family member 1B1transporter
CaspofunginSolute carrier organic anion transporter family member 1B3transporter
CaspofunginCytochrome P450 3A4enzyme
Caspofungin1,3-beta-glucan synthase component FKS1target
BacitracinInsulin-degrading enzymetarget
BacitracinC55-isoprenyl pyrophosphatetarget
BacitracinBacitracin transport ATP-binding protein BcrAtransporter
BacitracinBacitracin transport permease protein BCRBtransporter
BacitracinBacitracin transport permease protein BcrCtransporter
ColistinBacterial outer membranetarget
DactinomycinSolute carrier family 22 member 5transporter
DactinomycinP-glycoprotein 1transporter
DactinomycinMultidrug resistance-associated protein 6transporter
DactinomycinMultidrug resistance-associated protein 1transporter
DactinomycinATP-binding cassette sub-family G member 2transporter
DactinomycinDNA topoisomerase 2target
ColistimethateBacterial outer membranetarget
MicafunginArylsulfatase Aenzyme
MicafunginCatechol O-methyltransferaseenzyme
Micafungin1,3-beta-glucan synthase component FKS1target
Quinupristin23S ribosomal RNAtarget
Quinupristin50S ribosomal protein L10target
Quinupristin50S ribosomal protein L22target
QuinupristinCytochrome P450 3A4enzyme
Virginiamycin M1Streptogramin A acetyltransferasetarget
DalfopristinStreptogramin A acetyltransferasetarget
DalfopristinCytochrome P450 3A4enzyme
GallichromeIron(3+)-hydroxamate-binding protein FhuDtarget
Virginiamycin S160S ribosomal protein L37target
PlitidepsinCytochrome P450 3A4enzyme
PlitidepsinCytochrome P450 2A6enzyme
PlitidepsinCytochrome P450 2E1enzyme
PlitidepsinCytochrome P450 4A11enzyme
RomidepsinCytochrome P450 3A4enzyme
RomidepsinCytochrome P450 3A5enzyme
RomidepsinP-glycoprotein 1transporter
RomidepsinSolute carrier organic anion transporter family member 1B3transporter
RomidepsinCytochrome P450 1A1enzyme
RomidepsinCytochrome P450 2B6enzyme
RomidepsinCytochrome P450 2C19enzyme
RomidepsinHistone deacetylase 1target
RomidepsinHistone deacetylase 2target
RomidepsinHistone deacetylase 4target
RomidepsinHistone deacetylase 6target
RomidepsinMultidrug resistance-associated protein 1target
Viomycin16S/23S rRNA (cytidine-2'-O)-methyltransferase TlyAtarget
ValspodarSolute carrier organic anion transporter family member 1B1transporter
ValspodarSolute carrier organic anion transporter family member 1B3transporter
ValspodarP-glycoprotein 1transporter
TyrothricinPhospholipid membranetarget
Lutetium Lu 177 dotatateSomatostatin receptor type 2target
Lutetium Lu 177 dotatateSomatostatin receptor type 1target
Lutetium Lu 177 dotatateSomatostatin receptor type 3target
Lutetium Lu 177 dotatateSomatostatin receptor type 4target
Lutetium Lu 177 dotatateSomatostatin receptor type 5target
ValinomycinBile salt export pumptransporter
ValinomycinP-glycoprotein 1transporter
BasifunginInositol phosphorylceramide synthasetarget
VoclosporinCalcineurin subunit B type 1target
VoclosporinCalcineurin subunit B type 2target
VoclosporinP-glycoprotein 1transporter
VoclosporinCytochrome P450 3A4enzyme
VoclosporinCalcium signal-modulating cyclophilin ligandtarget
Polymyxin BBacterial outer membranetarget
Polymyxin BSolute carrier family 15 member 2transporter
EptifibatideIntegrin beta-3target
Dotatate gallium Ga-68Somatostatin receptor type 2target
Copper oxodotreotide Cu-64Somatostatin receptor type 2target