- Immunologic Factors
- Accession Number
Biologically active substances whose activities affect or play a role in the functioning of the immune system.
Drug Drug Description Etanercept A protein therapy based on the binding fragment of the tumour necrosis factor alpha receptor used to treat severe rheumatoid arthritis and moderate to severe plaque psoriasis. Sargramostim A modified form of recombinant human granulocyte-macrophage colony stimulating factor used to increase immune cell production after myelosuppressive therapy or bone marrow transplant. Human immunoglobulin G A purified form of human immunoglobulin G and other proteins used to treat immunodeficiency and a wide variety of autoimmune disorders. Interferon beta-1a A form of recombinant human interferon used to slow disease progression and reduce the frequency of clinical symptoms in patients who have relapsing multiple sclerosis. Interferon beta-1b A form of recombinant human interferon used to slow the progression of relapsing multiple sclerosis and to reduce the frequency of clinical symptoms. Rituximab A monoclonal anti-CD20 antibody used to treat non-Hodgkin's lymphoma, chronic lymphocytic leukemia, Wegener's granulomatosis, pemphigus vulgaris, and rheumatoid arthritis. Basiliximab A monoclonal anti-C25 antibody (interleukin-2 receptor alpha subunit) used as immunosuppressive therapy in kidney transplant patients. Cyclosporine A steroid-sparing immunosuppressant used in organ and bone marrow transplants as well as inflammatory conditions such as ulcerative colitis, rheumatoid arthritis, and atopic dermatitis. Natalizumab A monoclonal anti-integrin antibody which binds to the alpha 4 subunit of integrins to prevent migration of immune cells, and is used to treat Crohn's disease or multiple sclerosis. Daclizumab A monoclonal anti-CD25 antibody that blocks the interleukin-2 receptor which is used to treat relapsing forms of multiple sclerosis. Vitamin A A vitamin important for retinal function that is used clinically to correct vitamin A deficiency. Lenalidomide A thalidomide derivative used to treat multiple myeloma and anemia in low to intermediate risk myelodysplastic syndrome. Methotrexate An antineoplastic agent used the treatment of a wide variety of cancers as well as severe psoriasis, severe rheumatoid arthritis, and juvenile rheumatoid arthritis. Triamcinolone A glucocorticoid used to treat a wide variety of inflammatory conditions of organ systems and tissues. Mycophenolate mofetil An inosine monophosphate dehydrogenase inhibitor used to prevent the rejection of kidney, heart, or liver transplants. Tacrolimus A calcineurin inhibitor used to prevent organ transplant rejection and to treat moderate to severe atopic dermatitis. Sirolimus An mTOR inhibitor immunosuppressant used to prevent organ transplant rejections, treat lymphangioleiomyomatosis, and treat adults with perivascular epithelioid cell tumors. Azathioprine An immunosuppressant used to prevent renal transplant rejection, treat rheumatoid arthritis, Crohn's disease, and ulcerative colitis. Busulfan An alkylating agent used to treat chronic myelogenous leukemia. Abatacept A disease-modifying antirheumatic drug (DMARD) used in the management of rheumatic conditions, such as rheumatoid or psoriatic arthritis, and for the prophylaxis of acute graft-versus-host disease. Everolimus A mammalian target of rapamycin (mTOR) kinase inhibitor used to treat various types of malignancies. Prasterone A steroid formulated as a vaginal insert indicated for the treatment of moderate to severe dyspareunia associated with menopausal vulvar and vaginal atrophy. Arsanilic acid An arsenical which has been used as a feed additive for enteric conditions in pigs and poultry. It causes blindness and is ototoxic and nephrotoxic in animals. [PubChem] Ubenimex An adjuvant therapy used for acute and chronic myelonous leukemia, lung cancer and nasopharyngeal cancer. It is also used to treat hypercholesterolaemia. Seocalcitol Not Available Thymalfasin Indicated as an adjuvant for influenza vaccine in elderly patients and as an adjuvant for both influenza and hepatitis B vaccines in chronic hemodialysis patients who failed to achieve adequate... Afelimomab Investigated for use/treatment in sepsis and septicemia. Glatiramer An immunomodulator used to reduce the frequency of relapses in Multiple Sclerosis (MS). Keyhole limpet hemocyanin Investigated for use/treatment in bladder cancer and solid tumors. QS-21 Investigated for use/treatment in genital herpes, HIV infection, hepatitis (viral, B), influenza, malaria, melanoma, and viral infection. Human C1-esterase inhibitor A C1 inhibitor used to prevent angioedema attacks associated with hereditary angioedema. Belatacept A selective T-cell costimulation blocker used in the prophylaxis of organ rejection in adult patients receiving a kidney transplant. Hyaluronic acid A glycosaminoglycan used for the relief of joint pain, wound healing, ophthalmologic treatment, cosmetic treatment, and various other applications. GS 0573 Not Annotated Fingolimod A sphingosine 1-phosphate receptor modulator used to treat patients with the relapsing-remitting form of multiple sclerosis (MS) and studied to manage lung complications of COVID-19. Belimumab A B-lymphocyte stimulator (BLyS)-specific inhibitor that indirectly inhibits B cell survival, and is used to treat patients with autoantibody positive, active systemic lupus erythematosus. Certolizumab pegol A tumor necrosis factor (TNF) blocker used to treat a variety of autoimmune and autoinflammatory conditions like Crohn's disease, rheumatoid arthritis, active psoriatic arthritis, ankylosing spondylitis, axial spondyloarthritis, and plaque psoriasis. Pomalidomide A thalidomide analogue used in combination with dexamethasone to treat patients with multiple myeloma. Aluminum sulfate A medication used to prevent infections and to treat minor bleeding. Pidotimod A synthetic agent with immunomodulatory properties used in patients with documented cell-mediated immunosuppression to stimulate their immunity during lung and urinary tract infections. Roquinimex Roquinimex is investigated to be used as a treatment of a number of cancers and autoimmune conditions. As well, roquinimex is researched to be used as adjuvant therapy after bone... Recombinant Cholera Toxin B Subunit Recombinant Cholera Toxin B Subunit is an ingredient in the EMA-authorised product Dukoral. Benfotiamine A derivative of thiamine thought to be useful in the management of diabetic neuropathy, although evidence is lacking. Bryostatin 1 Bryostatin 1 has been investigated for the treatment of HIV Infection and Alzheimer's Disease. Guadecitabine Guadecitabine is under investigation for the treatment of Previously Treated Metastatic Colorectal Cancer. Benznidazole A trypanocidal agent used to treat Chagas disease. Thymopentin Thymopentin has been used in trials studying the treatment and prevention of HIV Infections and Hepatocellular Carcinoma. Semapimod Semapimod has been used in trials studying the treatment of Crohn Disease. Zuretinol acetate Zuretinol acetate has been used in trials studying the treatment of Impaired Dark Adaptation, RP (Retinitis Pigmentosa), Retinitis Pigmentosa (RP), and LCA (Leber Congenital Amaurosis). Squaric acid dibutyl ester Squaric acid dibutyl ester is under investigation in clinical trial NCT01971385 (Safety and Efficacy of Squaric Acid Dibutyl Ester for the Treatment of Herpes Labialis). KRN-7000 KRN7000 has been used in trials studying the treatment of Lung Cancer, Chronic Hepatitis C, Hepatitis B, Chronic, Unspecified Adult Solid Tumor, Protocol Specific, and Prevention of GvHD in Patients... Blisibimod Blisibimod has been used in trials studying the treatment of IgA Nephropathy, Microscopic Polyangiitis, Systemic Lupus Erythematosus, and Granulomatosis With Polyangiitis. Mizoribine Mizoribine has been investigated for the treatment of Rheumatoid Arthritis. Aviscumine Cy 503 is under investigation in clinical trial NCT00658437 (Aviscumine for the Treatment of Malignant Melanoma Stage IV After Failure of Prior Therapy). BCG vaccine A vaccine indicated in the prevention of tuberculosis and the treatment of non-invasive urothelial bladder cancer. Lenograstim A granulocyte colony-stimulating factor indicated in the reduction of duration of neutropenia in bone marrow transplant and cytotoxic chemotherapy, as well as mobilizing hematopoietic stem cells in healthy donors. Inosine pranobex A medication used to treat subacute sclerosing panencephalitis. Lentinan Not Annotated Meldonium Not Annotated Fosfructose A phosphorylated form of fructose indicated in the treatment of hypophosphatemia. Tetrandrine Not Annotated Distearyldimonium Not Annotated Brequinar Not Available Potassium alum Potassium alum is considered safe by the FDA and its use is in homepathic or OTC products. Due to its presence in several different drugs, the main indications for the... Human interferon beta A polypeptide drug used in the treatment of relapsing forms of Multiple Sclerosis (MS). Alefacept A recombinant fusion protein that binds CD2 and is used treat moderate to severe plaque psoriasis. Antithymocyte immunoglobulin (rabbit) A purified form of rabbit anti-thymocyte antibodies used for immunosuppression in patients receiving kidney transplants. ISS-1018 Investigated for use/treatment in colorectal cancer, hepatitis (viral, B), and lymphoma (non-hodgkin's). ISS 1018 is currently being investigated in combination with HBsAg vaccine as a prophylactic treatment for to prevent... Arylacenamide Investigated for use/treatment in cancer/tumors (unspecified), immunosuppressive, and prostate cancer. Lexatumumab Investigated for use/treatment in cancer/tumors (unspecified). Abetimus Investigated for use/treatment in kidney disease and systemic lupus erythematosus. Tafamidis A medication used to treat transthyretin-mediated amyloidosis. Ocrelizumab A CD20 specific monoclonal antibody used to treat relapsing remitting multiple sclerosis. Visilizumab Visilizumab has been investigated for the treatment of Ulcerative Colitis. Sifalimumab Sifalimumab is a fully human monoclonal antibody targeting interferon-alpha. The levels of interferon-alpha are elevated in many patients with active systemic lupus erythematosus (SLE, or lupus) and other autoimmune disorders,... Tocladesine Tocladesine has been used in trials studying the treatment of Colorectal Cancer and Multiple Myeloma and Plasma Cell Neoplasm. Edrecolomab Not Annotated Cridanimod Not Annotated Rozanolixizumab Rozanolixizumab is under investigation in clinical trial NCT03861481 (A Study to Assess the Efficacy, Safety and Tolerability of Rozanolixizumab in Subjects With Chronic Inflammatory Demyelinating Polyradiculoneuropathy). Umirolimus Not Annotated Ebola Zaire vaccine (live, attenuated) A vaccine used in the prophylaxis of Ebola virus disease caused by the species of Zaire ebolaviruses. 8-hydroxy-2'-deoxyguanosine Not Available Bropirimine Not Available Dethiobiotin Not Available Inolimomab Inolimomab is under investigation as an agent to treat steroid-resistant graft vs host disease. It has thus far offered similar efficacy to other monoclonal antibody options, though it may carry... Maritime pine extract A plant extract in nutritional supplements for healthy hair, skin, and nails. OM85 OM-85, a bacterial extract, is an immunomodulator of interferon-β production and inflammasome activity. Lithium chloride An injection indicated for cardiac output measurement. Antilymphocyte immunoglobulin (horse) A primarily IgG immune globulin used to manage allograft rejection in renal transplant patients.
- Drugs & Drug Targets