Sodium lauryl sulfoacetate

Identification

Name
Sodium lauryl sulfoacetate
Accession Number
DB13157
Description

Sodium lauryl sulfoacetate is a wetting agent and surfactant used in enema-type laxative products.

Type
Small Molecule
Groups
Approved, Experimental
Structure
Thumb
Weight
Average: 330.41
Monoisotopic: 330.14768942
Chemical Formula
C14H27NaO5S
Synonyms
  • Lathanol
  • Lathanol LAL
  • Sulfoacetic acid dodecyl ester S-sodium salt

Pharmacology

Pharmacology
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Indication

Sodium lauryl sulfoacetate is not an active pharmacological ingredient in pharmaceutical preparations and so has no official indication.

Associated Conditions
Associated Therapies
Contraindications & Blackbox Warnings
Contraindications
Contraindications & Blackbox Warnings
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Pharmacodynamics

Sodium lauryl sulfoacetate acts as a wetting agent and surfactant in pharmaceutical preparations 1. It is currently used in enema-type laxatives.

Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half-life
Not Available
Clearance
Not Available
Adverse Effects
Medicalerrors
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Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
No interactions found.

Products

Products
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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Microlax Micro EnemaSodium lauryl sulfoacetate (9 mg) + Sodium citrate (90 mg) + Sorbitol (625 mg)Enema; LiquidRectalMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1995-12-312020-08-06Canada flag
Microlax Micro-enemaSodium lauryl sulfoacetate (9 g) + Sodium citrate (90 g) + Sorbitol (625 g)LiquidRectalKabi Pharmacia Canada Inc.1993-12-311996-09-10Canada flag

Categories

ATC Codes
A06AG11 — Sodium lauryl sulfoacetate, incl. combinations
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as organosulfonic acids. These are compounds containing the sulfonic acid group, which has the general structure RS(=O)2OH (R is not a hydrogen atom).
Kingdom
Organic compounds
Super Class
Organic acids and derivatives
Class
Organic sulfonic acids and derivatives
Sub Class
Organosulfonic acids and derivatives
Direct Parent
Organosulfonic acids
Alternative Parents
Sulfonyls / Alkanesulfonic acids / Carboxylic acid esters / Monocarboxylic acids and derivatives / Organic sodium salts / Organic oxides / Hydrocarbon derivatives / Carbonyl compounds / Organic cations
Substituents
Aliphatic acyclic compound / Alkanesulfonic acid / Carbonyl group / Carboxylic acid derivative / Carboxylic acid ester / Hydrocarbon derivative / Monocarboxylic acid or derivatives / Organic alkali metal salt / Organic cation / Organic oxide
Molecular Framework
Aliphatic acyclic compounds
External Descriptors
Not Available

Chemical Identifiers

UNII
D0Y70F2B9J
CAS number
1847-58-1
InChI Key
UAJTZZNRJCKXJN-UHFFFAOYSA-M
InChI
InChI=1S/C14H28O5S.Na/c1-2-3-4-5-6-7-8-9-10-11-12-19-14(15)13-20(16,17)18;/h2-13H2,1H3,(H,16,17,18);/q;+1/p-1
IUPAC Name
sodium 2-(dodecyloxy)-2-oxoethane-1-sulfonate
SMILES
[Na+].CCCCCCCCCCCCOC(=O)CS([O-])(=O)=O

References

General References
  1. US Patent 3211614 [Link]
PubChem Compound
23668827
PubChem Substance
347829267
ChemSpider
15024
RxNav
314832
Wikipedia
Sodium_citrate/sodium_lauryl_sulfoacetate/glycerol

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
EnemaRectal4.465 g/5ml
EnemaRectal45 mg
Enema; liquidRectal
LiquidRectal
EmulsionRectal900 mg
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.00576 mg/mLALOGPS
logP4.49ALOGPS
logP4ChemAxon
logS-4.8ALOGPS
pKa (Strongest Acidic)-1.1ChemAxon
pKa (Strongest Basic)-7.3ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area83.5 Å2ChemAxon
Rotatable Bond Count14ChemAxon
Refractivity77.32 m3·mol-1ChemAxon
Polarizability34.95 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available

Drug created on December 05, 2016 03:16 / Updated on June 12, 2020 16:53