Drugs for Constipation

Drugs for Constipation
Accession Number
DBCAT002415  (DBCAT001909)

Not Available

ATC Classification
DrugDrug Description
LactuloseA disaccharide derivative of lactose used to treat constipation and portal systemic encephalopathy.
LubiprostoneA prostaglandin derivative used to treat constipation caused by irritable bowel syndrome and opioid-use.
TegaserodA serotonin-4 (5-HT4) receptor agonist indicated for the treatment of constipation predominant irritable bowel syndrome (IBS-C) specifically in women under the age of 65. There is currently no safety or efficacy data for use of tegaserol in men.
DantronA drug used to relieve acute and chronic inflammation of the oral cavity and oropharynx.
OxyphenisatinA laxative that undergoes enterohepatic circulation. It may cause jaundice.
PhenolphthaleinA drug used for symptomatic relief of constipation and bowel cleansing prior to medical procedures.
AlvimopanAn opioid antagonist used to reduce healing time of the upper and lower gastrointestinal tract following surgical procedures that involve bowel resection with primary anastomosis.
PrucaloprideA 5-HT4 receptor agonist indicated to treat adults with chronic idiopathic constipation.
MethylnaltrexoneA μ-opioid antagonist used for the treatment of opioid-induced constipation in palliative patients that are inadequately responding to laxative therapy.
LinaclotideA guanylate cyclase-C agonist used to treat constipation associated with irritable bowel syndrome or that is idiopathic in nature.
BisacodylA stimulant laxative used for the temporary relief of occasional constipation and cleansing of the colon as a preparation for colonoscopy in adults.
NaloxegolA peripherally-selective opioid antagonist used to treat opioid-induced constipation (OIC) in adult patients with chronic non-cancer pain.
BisoxatinFor use in the treatment of constipation in the absence of bowel obstruction and for surgical preparation of the colon .
Picosulfuric acidA stimulant laxative used for cleansing of the colon as a preparation for colonoscopy in adults.
Polyethylene glycolA laxative used to treat constipation and used for bowel preparation before colonoscopies and other procedures.
GlycerinIt is used as a solvent, emollient, pharmaceutical agent, and sweetening agent.
Sodium sulfateAn agent used for bowel cleansing prior to colonoscopy or barium enema X-ray examination.
Magnesium carbonateAn antacid used for symptomatic relief of heartburn, indigestion, and upset stomach.
Mineral oilMineral oil is not considered an active pharmacological ingredient in pharmaceutical preparations and so has no official indication. It is typically present in topical formulations as an emollient and occlusive...
DocusateA medication used to treat constipation associated with dry, hard stools, or opioid induced constipation.
Magnesium citrateA laxative used in bowel preparation for colonoscopy or as a magnesium supplement.
Castor oilAn ingredient used in a variety of natural health products.
MethylcelluloseA compound used as a bulk forming laxative and is not an approved medication.
SennosidesA laxative used to treat constipation.
LactitolAn orally administered osmotic laxative used to treat chronic idiopathic constipation.
Sodium lauryl sulfoacetateA laxative indicated in the treatment of constipation and bowel preparation for rectal endoscopy.
PentaerithritylNot Annotated
Sodium tartrateIt acts as an emulsifier and pH control agent in food products , . In the laboratory, it is used while performing the Karl Fischer equation, which is used to...
Magnesium sulfateA drug used to treat convulsions during pregnancy, nephritis in children, magnesium deficiency, and tetany.
MannitolA sugar alcohol used to test for asthma, to reduce intracranial and intraocular pressure, to measure glomerular filtration rate, and to manage pulmonary symptoms associated with cystic fibrosis.
Magnesium oxideA compound commonly used as a laxative for the symptomatic relief of acid indigestion and upset stomach, and in health supplements for cardiovascular and neuromuscular health.
SorbitolA product that can be used as a laxative to relieve constipation, and also as a urologic irrigating fluid. May also be used as a pharmaceutical sweetener.
Magnesium peroxideNot Annotated
Plantago ovata seedA plant extract indicated in the treatment of occasional constipation.
Calcium polycarbophilA bulk forming laxative used to treat constipation.
NaloxoneAn opioid receptor antagonist used to rapidly reverse an opioid overdose. Also included in some drug formulations as an abuse deterrent to prevent injection.
NaldemedineAn opioid antagonist used to to treat opioid-induced constipation.
PlecanatideA laxative used to treat chronic idiopathic constipation and IBS with constipation.
Karaya gumAn extract from Karaya gum used in allergy testing.
Sodium phosphate, monobasicA source of phosphorus used prevent or correct hypophosphatemia in patients with restricted or no oral intake.
TenapanorAn NHE3 inhibitor indicated for the treatment of constipation-predominant irritable bowel syndrome (IBS-C).
Drugs & Drug Targets
LactuloseEvolved beta-galactosidase subunit alphatarget
LubiprostoneChloride channel protein 2target
LubiprostoneCarbonyl reductase [NADPH] 1enzyme
Tegaserod5-hydroxytryptamine receptor 4target
Tegaserod5-hydroxytryptamine receptor 2Btarget
Tegaserod5-hydroxytryptamine receptor 2Ctarget
Tegaserod5-hydroxytryptamine receptor 2Atarget
TegaserodSodium-dependent serotonin transportertransporter
TegaserodCytochrome P450 1A2enzyme
TegaserodCytochrome P450 2C8enzyme
TegaserodCytochrome P450 2D6enzyme
TegaserodCytochrome P450 2E1enzyme
TegaserodATP-binding cassette sub-family G member 2transporter
TegaserodP-glycoprotein 1transporter
DantronSerum albumincarrier
PhenolphthaleinUDP-glucuronosyltransferase 1-9target
PhenolphthaleinNuclear receptor subfamily 1 group I member 2target
PhenolphthaleinNuclear receptor subfamily 1 group I member 3target
PhenolphthaleinEstrogen receptor alphatarget
PhenolphthaleinSex hormone-binding globulintarget
AlvimopanMu-type opioid receptortarget
AlvimopanKappa-type opioid receptortarget
AlvimopanDelta-type opioid receptortarget
Prucalopride5-hydroxytryptamine receptor 4target
PrucaloprideCytochrome P450 3A4enzyme
PrucaloprideSerum albumincarrier
PrucaloprideP-glycoprotein 1transporter
MethylnaltrexoneMu-type opioid receptortarget
MethylnaltrexoneKappa-type opioid receptortarget
LinaclotideHeat-stable enterotoxin receptortarget
BisacodylSodium/Potassium Transporting ATPasetarget
NaloxegolCytochrome P450 3A4enzyme
NaloxegolCytochrome P450 2D6enzyme
NaloxegolCytochrome P450 2C19enzyme
NaloxegolMu-type opioid receptortarget
Picosulfuric acidArylsulfate sulfotransferaseenzyme
Polyethylene glycolP-glycoprotein 1transporter
GlycerinGroup IIE secretory phospholipase A2target
GlycerinInositol-3-phosphate synthase 1target
GlycerinAlcohol dehydrogenase 1Btarget
GlycerinInositol 1,4,5-trisphosphate receptor type 1target
GlycerinADP-ribosylation factor 1target
GlycerinBifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1target
GlycerinDNA mismatch repair protein MutLtarget
GlycerinRibonucleoside-diphosphate reductase 1 subunit betatarget
GlycerinA/G-specific adenine glycosylasetarget
GlycerintRNA (cytosine(38)-C(5))-methyltransferasetarget
GlycerinCytochrome P450 2E1enzyme
GlycerinRetinal dehydrogenase 1enzyme
GlycerinPeroxisome proliferator-activated receptor deltatarget
GlycerinMaleylacetoacetate isomerasetarget
GlycerinGlycerol uptake facilitator proteintransporter
Sodium sulfateCarbonic anhydrase 2target
Sodium sulfateCarbonic anhydrase 1target
Magnesium carbonateTransient receptor potential cation channel subfamily M member 6transporter
Magnesium carbonateSolute carrier family 41 member 3transporter
Magnesium carbonateMetal transporter CNNM2transporter
Magnesium carbonateTransient receptor potential cation channel subfamily M member 7transporter
Magnesium carbonateGlutamate (NMDA) receptortarget
Castor oilProstaglandin E2 receptor EP3 subtypetarget
Castor oilProstaglandin E2 receptor EP4 subtypetarget
SennosidesReverse transcriptase/RNaseHtarget
Magnesium sulfateVoltage-dependent L-type calcium channeltarget
MannitolMannitol dehydrogenaseenzyme
NaloxoneMu-type opioid receptortarget
NaloxoneEstrogen receptor alphatarget
NaloxoneCyclic AMP-responsive element-binding protein 1target
NaloxoneDelta-type opioid receptortarget
NaloxoneSolute carrier organic anion transporter family member 1A2transporter
NaloxoneP-glycoprotein 1transporter
NaloxoneKappa-type opioid receptortarget
NaloxoneCytochrome P450 3A4enzyme
NaloxoneSerum albumincarrier
NaloxoneToll-like receptor 4target
NaloxoneLiver carboxylesterase 1target
NaloxoneUDP-glucuronosyltransferase 1-1enzyme
NaloxoneCytochrome P450 2C18enzyme
NaloxoneCytochrome P450 2C19enzyme
NaldemedineCytochrome P450 3A Subfamilyenzyme
NaldemedineUDP-glucuronosyltransferase 1-3enzyme
NaldemedineMu-type opioid receptortarget
NaldemedineDelta-type opioid receptortarget
NaldemedineKappa-type opioid receptortarget
NaldemedineATP-binding cassette sub-family B member 5transporter
PlecanatideGuanylate cyclase soluble subunit alpha-2target
Sodium phosphate, monobasicSodium-dependent phosphate transporter 1transporter
Sodium phosphate, monobasicSodium-dependent phosphate transporter 2transporter
Sodium phosphate, monobasicSodium-dependent phosphate transport protein 2Atransporter
Sodium phosphate, monobasicSodium-dependent phosphate transport protein 2Btransporter
Sodium phosphate, monobasicSodium-dependent phosphate transport protein 2Ctransporter
TenapanorSodium/hydrogen exchanger 3target
TenapanorCytochrome P450 3A4enzyme
TenapanorCytochrome P450 3A5enzyme
TenapanorSolute carrier organic anion transporter family member 2B1transporter