Spiro Compounds

Name
Spiro Compounds
Accession Number
DBCAT000923
Description

A group of compounds consisting in part of two rings sharing one atom (usually a carbon) in common.

Drugs
DrugDrug Description
BuspironeAn anxiolytic agent used for short-term treatment of generalized anxiety and second-line treatment of depression.
EosinA medication used to disinfect small skin wounds, bug bites, and sores.
FluoresceinA dye used in angiography or angioscopy of the iris and retina.
Fluorescein lisicolFluorescein lisicol has been used in trials studying the diagnostic of Pharmacokinetics, Hepatic Cirrhosis, Hepatitis, Viral, Human, Nonalcoholic Steatohepatitis, and Non-Alcoholic Fatty Liver Disease.
FluspirileneAn antipsychotic agent used in the treatment of schizophrenia.
IrbesartanAn angiotensin receptor blocker used to treat hypertension, delay progression of diabetic nephropathy, and treat congestive heart failure.
MerbrominA topical antiseptic indicated in the disinfection of lacerations.
Phloxine BFor use in dental disclosing products, allowing for highlighting of bacterial placques.
Rose bengalIndicated as a diagnostic agent in routine ocular examinations or when superficial conjunctiva or corneal tissue change is suspected, and as an aid in the diagnosis of keratoconjunctivitis sicca, keratitis,...
Rose bengal I-131Not Annotated
SpiperoneSpiperone is a dopamine antagonist that binds dopamine and serotonin receptors.
Drugs & Drug Targets
DrugTargetType
Buspirone5-hydroxytryptamine receptor 1Atarget
BuspironeDopamine receptor D2target
BuspironeCytochrome P450 3A4enzyme
BuspironeCytochrome P450 3A5enzyme
BuspironeCytochrome P450 3A7enzyme
BuspironeATP-dependent translocase ABCB1transporter
BuspironeCytochrome P450 2D6enzyme
BuspironeAlbumincarrier
BuspironeAlpha-1-acid glycoprotein 1carrier
BuspironeDopamine receptor D3target
BuspironeDopamine receptor D4target
BuspironeAlpha-1 adrenergic receptorstarget
EosinSodium/Potassium Transporting ATPasetarget
EosinPlasma membrane calcium-transporting ATPasetarget
FluoresceinDNAtarget
FluoresceinSolute carrier family 22 member 6transporter
FluoresceinBile salt export pumptransporter
FluoresceinImmunoglobulin kappa variable 2-30target
FluoresceinOrganic anion transporter 3target
FluoresceinATP-binding cassette sub-family C member 1transporter
FluspirileneDopamine receptor D2target
Fluspirilene5-hydroxytryptamine receptor 2Atarget
FluspirileneVoltage-dependent calcium channel gamma-1 subunittarget
FluspirileneCytochrome P450 3A4enzyme
IrbesartanType-1 angiotensin II receptortarget
IrbesartanTranscription factor Juntarget
IrbesartanCytochrome P450 2C9enzyme
IrbesartanCytochrome P450 2C8enzyme
IrbesartanUDP-glucuronosyltransferase 1A3enzyme
IrbesartanProstaglandin G/H synthase 1enzyme
IrbesartanCytochrome P450 3A4enzyme
IrbesartanAlbumincarrier
Irbesartanalpha1-acid glycoproteincarrier
MerbrominGlutathione S-transferase A3target
MerbrominFructose-bisphosphate aldolase Atarget
MerbrominDual specificity protein phosphatase 5target
MerbrominReplicase polyprotein 1abtarget
MerbrominAspartate aminotransferase, cytoplasmictarget
MerbrominGlutathione S-transferase Ptarget
Phloxine BCystic fibrosis transmembrane conductance regulatortarget
Phloxine BATP-sensitive potassium channeltarget
Phloxine BPoly(ADP-ribose) glycohydrolasetarget
Phloxine BCytochrome P450 3A4enzyme
Phloxine BATP-dependent translocase ABCB1transporter
Phloxine BIodotyrosine deiodinase 1target
Rose bengalLysozyme Cenzyme
Rose bengalHuman vesicular glutamate transporterstarget
Rose bengalSynaptic vesicular amine transportertarget
Rose bengalVesicular acetylcholine transportertarget
Rose bengalMicrotubule-associated protein tautarget
Rose bengalGlutathione S-transferases (Cytosolic)enzyme
Rose bengalLactotransferrincarrier
Rose bengalSerotransferrincarrier
Rose bengalAlbumincarrier
SpiperoneDopamine receptor D3target
SpiperoneDopamine receptor D4target
SpiperoneDopamine receptor D2target
Spiperone5-hydroxytryptamine receptor 7target
SpiperoneAlpha-1A adrenergic receptortarget
Spiperone5-hydroxytryptamine receptor 2Atarget
Spiperone5-hydroxytryptamine receptor 1Atarget
Spiperone5-hydroxytryptamine receptor 6target