Metals, Heavy

Metals, Heavy
Accession Number

Metals with high specific gravity, typically larger than 5. They have complex spectra, form colored salts and double salts, have a low electrode potential, are mainly amphoteric, yield weak bases and weak acids, and are oxidizing or reducing agents (From Grant & Hackh's Chemical Dictionary, 5th ed)

DrugDrug Description
Bismuth subsalicylateAn antidiarrheal and anti-inflammatory agent used for symptomatic treatment of nausea, indigestion, upset stomach, diarrhea, and other temporary discomforts of the stomach and gastrointestinal tract.
ManganeseA transition metal used for supplementation of manganese during Total Parenteral Nutrition (TPN).
CopperA transition metal found in a variety of supplements and vitamins, including intravenous solutions for total parenteral nutrition (TPN).
IndiumIndium has been used in trials studying the basic science of Clear Cell Renal Cell Carcinoma.
TantalumTantalum has been investigated for the treatment and prevention of Osteoarthritis, Knee Osteoarthritis, Intraoperative Bleeding, and Adolescent Idiopathic Scoliosis.
ActiniumActinium has been investigated for the treatment of Breast Cancer and Pulmonary Disease, Chronic Obstructive.
SilverIndicated for the treatment of acne for topical use or the management of dental caries for dental use.
BerkeliumBerkelium is under investigation in clinical trial NCT02189122 (Comparative Effects of Aspirin and NHP-544C).
NiobiumNiobium has been used in trials studying the treatment of Obesity and Overweight.
VanadiumA micronutrient used in some multivitamins and parenteral nutrition.
CadmiumAn element with atomic symbol Cd, atomic number 48, and atomic weight 112.41. It is a metal and ingestion will lead to CADMIUM POISONING.
CobaltA metal element used in various nutritional products.
CesiumCesium is under investigation in clinical trial NCT02794675 (Intraoperative Placement of Cesium-131 Permanent Interstitial Brachytherapy in Head and Neck Cancer).
IronAn essential element commonly used for the treatment of patients with documented iron deficiency.
ZincAn essential element commonly used for the treatment of patients with documented zinc deficiency.
ChromiumAn ingredient found in a variety of supplements and vitamins.
MolybdenumAn ingredient found in a variety of supplements and vitamins.
RubidiumNot Annotated
PlatinumPlatinum is under investigation for the treatment of Metastatic Breast Cancer, Non-small Cell Lung Cancer, Gastric Large Cell Neuroendocrine Carcinoma, Colorectal Large Cell Neuroendocrine Carcinoma, and Pancreatic Large Cell Neuroendocrine...
BariumBarium is under investigation for the diagnostic of Known or Suspected Abdominal Disease.
AntimonyAntimony has been used in trials studying the treatment of Cutaneous Leishmaniasis.
GoldA yellow metallic element with the atomic symbol Au, atomic number 79, and atomic weight 197. It is used in jewelry, goldplating of other metals, as currency, and in dental...
Technetium Tc-99mA radiopharmaceutical indicated in imaging tests.
M40403Intended for the treatment of pain and possibly various forms of cancer.
TetrathiomolybdateInvestigated for use/treatment in liver disease and pulmonary fibrosis.
Gallium nitrateA drug previously indicated to treat cancer-related hypercalcemia.
Radium Ra 223 dichlorideA radiopharmaceutical agent used to treat patients with castration-resistant prostate cancer, symptomatic bone metastases and no known visceral metastatic disease.
Cupric ChlorideA transition metal found in a variety of supplements and vitamins, including intravenous solutions for total parenteral nutrition (TPN).
Ferric pyrophosphateFerric pyrophosphate is intended to be indicated for the treatment of iron loss or iron deficiency as a formulation with a milder gastrointestinal effect.[L1423, L1433] Iron deficiency appears when the...
Thallous chlorideA diagnostic radiopharmaceutical for myocardial perfusion testing and tests of parathyroid function.
Strontium chloride Sr-89A radiopharmaceutical agent used for the relief of bone pain in patients with painful skeletal metastases.
Ammonium molybdateAmmonium molybdate is a source of molybdenum that exists in several hydrate forms. It is intravenously administered as an additive to solutions for Total Parenteral Nutrition (TPN). Molybdenum is an...
Cupric oxideAn ingredient found in a variety of supplements and vitamins.
Chromium Cr-51Chromium Cr-51 is an isotope of chromium that has been used as a radioactive label for decades. It is used as a diagnostic radiopharmaceutical agent in nephrology to determine glomerular...
Bismuth subcarbonateNot Annotated
Radium Ra-223Radium 223 is under investigation in clinical trial NCT02463799 (Ph 2 Study of Sipuleucel-T W/ or W/O Radium-223 in Men With Asymptomatic or Minimally Symptomatic Bone-MCRPC).
PerflubutanePerflubutane has been used in trials studying the diagnostic of Liver Mass, Liver Diseases, Liver Metastasis, Portal Hypertension, and Peripheral Artery Disease. It is a cardiovascular drug designed to enable...
Bismuth subnitrateA medication used as an antacid.
Gold Au-198Not Annotated
Antimony pentasulfideNot Annotated
Strontium chlorideA medication used to treat bone pain in skeletal metastases.
Nickel sulfateNickel sulfate is used in allergenic testing.
Cobalt chlorideNot Annotated
Sodium molybdateNot Annotated
Bevacizumab zirconium Zr-89Bevacizumab zirconium Zr-89 is under investigation in clinical trial NCT01338090 (89Zr-bevacizumab PET Imaging in Patients With Neuroendocrine Tumors).
Cobalt Co-60Cobalt Co-60 is under investigation in clinical trial NCT02891083 (Adjuvant Therapies or Surgery Alone for High Risk pN0 Esophageal Cancer).
Cuprous chlorideNot Annotated
Cobaltous sulfateA micronutrient found in some multivitamins.
MolybdateNot Annotated
Molybdenum trioxideNot Annotated
Bismuth oxideNot Annotated
Gallium Ga-68 gozetotideA radiopharmaceutical agent used in the diagnosis of prostate-specific membrane antigen (PSMA) positive lesions in male patients during positron emission tomography.
Zirconium dioxideNot Annotated
Hafnium oxideNot Annotated
PropagermaniumNot Annotated
Ammonium tetrathiomolybdateNot Annotated
HPA-23HPA-23 is an investigational antiviral compound.
Gallium citrateNot Annotated
Drugs & Drug Targets
Bismuth subsalicylateSerum albumincarrier
Bismuth subsalicylateSerotransferrincarrier
ManganeseCytoplasmic aconitate hydrataseenzyme
ManganeseIsocitrate dehydrogenase [NAD] subunit alpha, mitochondrialtarget
ManganeseIsocitrate dehydrogenase [NAD] subunit gamma, mitochondrialtarget
ManganeseTGF-beta-activated kinase 1 and MAP3K7-binding protein 1target
CopperSuperoxide dismutase [Cu-Zn]enzyme
CopperAmiloride-sensitive amine oxidase [copper-containing]enzyme
CopperProtein-lysine 6-oxidaseenzyme
CopperHigh affinity copper uptake protein 1transporter
CopperNatural resistance-associated macrophage protein 2transporter
CopperSerum albumincarrier
CopperCopper transport protein ATOX1carrier
CopperCopper-transporting ATPase 1transporter
CopperCopper-transporting ATPase 2transporter
CopperCopper chaperone for superoxide dismutasecarrier
CopperCytochrome c oxidase copper chaperonecarrier
CopperCytochrome c oxidase subunit 1enzyme
CopperDopamine beta-hydroxylaseenzyme
CopperPeptidyl-glycine alpha-amidating monooxygenaseenzyme
CopperMonoamine oxidaseenzyme
CopperAmyloid beta A4 proteintarget
CopperMajor prion proteinenzyme
CopperCoagulation factor Vcarrier
CopperCoagulation factor VIIIcarrier
CopperProbable low affinity copper uptake protein 2transporter
CopperHistone H2B type 1-C/E/F/G/Itarget
CopperGlyceraldehyde-3-phosphate dehydrogenasetarget
CopperNucleoside diphosphate kinase Atarget
CopperHistone H1.4target
CopperProtein S100-A8target
Copper40S ribosomal protein SAtarget
CopperActin, cytoplasmic 2target
CopperElongation factor 1-alpha 1target
CopperKeratin, type II cytoskeletal 8target
CopperProtein disulfide-isomerasetarget
CopperProtein disulfide-isomerase A3target
Copper60 kDa heat shock protein, mitochondrialtarget
CopperHeat shock 70 kDa protein 13target
Copper78 kDa glucose-regulated proteintarget
CopperCell growth-regulating nucleolar proteintarget
Copper40S ribosomal protein S2target
CopperSerine/arginine-rich splicing factor 1target
CopperHeterogeneous nuclear ribonucleoproteins A2/B1target
CopperHeterogeneous nuclear ribonucleoprotein Htarget
CopperHeterogeneous nuclear ribonucleoprotein H3target
CopperCobalt-precorrin-5B C(1)-methyltransferasetarget
CopperHeterogeneous nuclear ribonucleoprotein Ltarget
CopperSplicing factor, proline- and glutamine-richtarget
CopperSplicing factor 3A subunit 2target
CopperReceptor of activated protein C kinase 1target
CopperAnnexin A4target
CopperAnnexin A5target
CopperPyruvate kinase PKMtarget
CopperAlcohol dehydrogenase [NADP(+)]target
CopperNADH-cytochrome b5 reductase 3target
CopperGlutathione reductase, mitochondrialtarget
CopperPeptidyl-prolyl cis-trans isomerase Atarget
CopperHeat shock cognate 71 kDa proteintarget
CopperHeat shock protein HSP 90-alphatarget
CopperProstaglandin E synthase 3target
CopperStress-induced-phosphoprotein 1target
CopperTranslation elongation factor 1 alpha 1-like 14target
CopperEukaryotic translation initiation factor 6target
CopperEukaryotic initiation factor 4A-Itarget
CopperGlucose-6-phosphate isomerasetarget
CopperL-lactate dehydrogenase A chaintarget
CopperPhosphoglycerate kinase 1target
CopperTubulin alpha 3C/D chaintarget
CopperTubulin beta chaintarget
Copper14-3-3 protein beta/alphatarget
CopperAspartate aminotransferase, cytoplasmictarget
CopperGlutathione synthetasetarget
CopperHepatoma-derived growth factortarget
CopperIsocitrate dehydrogenase [NAD] subunit alpha, mitochondrialtarget
CopperChloride intracellular channel protein 1target
CopperProteasome activator complex subunit 1target
CopperPhosphatidylethanolamine-binding protein 1target
CopperPhosphoglycerate mutase 1target
CopperRan-specific GTPase-activating proteintarget
CopperUDP-glucose 6-dehydrogenasetarget
CopperProtein SCO1 homolog, mitochondrialtarget
CopperAlternative prion proteintarget
CopperGlycine receptor subunit alpha-1target
CopperEndonuclease 8-like 1target
CopperEndonuclease 8-like 2target
CopperHephaestin-like protein 1target
CopperPlasminogen activator inhibitor 1target
CopperProtein S100-A2target
CopperProtein S100-A4target
CopperBrain-derived neurotrophic factortarget
CopperProtein DJ-1target
CopperIslet amyloid polypeptidetarget
CopperSerum amyloid P-componenttarget
CopperApolipoprotein A-Itarget
CopperApolipoprotein A-IItarget
CopperApolipoprotein A-IVtarget
CopperApolipoprotein B receptortarget
CopperApolipoprotein C-IItarget
CopperApolipoprotein C-IIItarget
CopperApolipoprotein Dtarget
CopperApolipoprotein Etarget
CopperBeta-2-glycoprotein 1target
CopperComplement C1q subcomponent subunit Ctarget
CopperComplement C1s subcomponenttarget
CopperComplement C3target
CopperComplement C4-Btarget
CopperC4b-binding protein alpha chaintarget
CopperComplement C5target
CopperComplement component C8 beta chaintarget
CopperComplement component C9target
CopperComplement factor Htarget
CopperComplement factor Itarget
CopperComplement component 1 Q subcomponent-binding protein, mitochondrialtarget
CopperHemoglobin subunit alphatarget
CopperHemoglobin subunit betatarget
CopperChromobox protein homolog 5target
CopperHaptoglobin-related proteintarget
CopperInsulin-like growth factor-binding protein complex acid labile subunittarget
CopperIg gamma-1 chain C regiontarget
CopperIg gamma-4 chain C regiontarget
CopperIg kappa chain V-III region GOLtarget
CopperImmunoglobulin lambda-like polypeptide 1target
CopperInter-alpha-trypsin inhibitor heavy chain H2target
CopperKeratin, type II cytoskeletal 1target
CopperKeratin, type I cytoskeletal 10target
CopperKeratin, type II cytoskeletal 2 epidermaltarget
CopperKeratin, type I cytoskeletal 9target
CopperLeucine-rich alpha-2-glycoproteintarget
CopperN-acetylmuramoyl-L-alanine amidasetarget
CopperSerum paraoxonase/arylesterase 1target
CopperPlatelet basic proteintarget
CopperCorticosteroid-binding globulintarget
CopperThyroxine-binding globulintarget
CopperHeparin cofactor 2target
CopperPigment epithelium-derived factortarget
CopperPlasma protease C1 inhibitortarget
CopperAmyloid-like protein 1target
SilverSerum albumintarget
IronTransferrin receptor protein 1target
IronEgl nine homolog 1target
IronHistone deacetylase 8target
IronAlpha-hemoglobin-stabilizing proteintarget
IronHemoglobin subunit alphatarget
IronFrataxin, mitochondrialtarget
IronFerritin heavy chaintarget
IronFlap endonuclease 1target
IronEndonuclease 8-like 1target
IronEndonuclease 8-like 2target
IronDNA polymerase betatarget
ZincB1 bradykinin receptortarget
ZincMethylated-DNA--protein-cysteine methyltransferasetarget
ZincFructose-bisphosphate aldolase Atarget
ZincElongation factor 1-alpha 1target
ZincGlyceraldehyde-3-phosphate dehydrogenase, testis-specifictarget
ZincNucleoside diphosphate kinase Atarget
ZincProtein disulfide-isomerasetarget
ZincProtein disulfide-isomerase A3target
ZincPhosphoserine phosphatasetarget
ZincTriosephosphate isomerasetarget
ZincElongation factor Tu, mitochondrialtarget
ZincEstrogen receptor alphatarget
ZincCopper chaperone for superoxide dismutasetarget
ZincHistone deacetylase 1target
ZincHistone deacetylase 4target
ZincDNA-3-methyladenine glycosylasetarget
ZincSuperoxide dismutase [Cu-Zn]target
ZincHistone deacetylase 8target
ZincApoptosis regulatory protein Sivatarget
ZincGlycine receptor subunit alpha-1target
ZincE3 ubiquitin-protein ligase Mdm2target
ZincProtein S100-A8target
ZincProtein S100-A9target
ZincMatrix metalloproteinase-9target
ZincTumor protein p73target
ZincProtein S100-A2target
ZincCellular tumor antigen p53target
ZincProgrammed cell death protein 6target
ZincDAN domain family member 5target
ZincSerum amyloid P-componenttarget
ZincApolipoprotein A-Itarget
ZincApolipoprotein A-IItarget
ZincApolipoprotein A-IVtarget
ZincApolipoprotein B receptortarget
ZincApolipoprotein Etarget
ZincApolipoprotein L1target
ZincComplement C1q subcomponent subunit Btarget
ZincComplement C1q subcomponent subunit Ctarget
ZincComplement C1r subcomponenttarget
ZincComplement C1s subcomponenttarget
ZincComplement C3target
ZincComplement C4-Btarget
ZincC4b-binding protein alpha chaintarget
ZincC4b-binding protein beta chaintarget
ZincComplement C5target
ZincLys-63-specific deubiquitinase BRCC36target
ZincComplement component C8 alpha chaintarget
ZincComplement component C8 beta chaintarget
ZincComplement component C8 gamma chaintarget
ZincComplement factor Btarget
ZincComplement factor Htarget
ZincComplement factor Itarget
ZincCarboxypeptidase N catalytic chaintarget
ZincCarboxypeptidase N subunit 2target
ZincCoagulation factor XIItarget
ZincCoagulation factor XIII B chaintarget
ZincFibrinogen alpha chaintarget
ZincHemoglobin subunit alphatarget
ZincHemoglobin subunit betatarget
ZincHaptoglobin-related proteintarget
ZincInsulin-like growth factor-binding protein complex acid labile subunittarget
ZincIg alpha-1 chain C regiontarget
ZincIg mu chain C regiontarget
ZincImmunoglobulin kappa variable 1-17target
ZincIg kappa chain V-III region GOLtarget
ZincImmunoglobulin lambda variable 3-21target
ZincInter-alpha-trypsin inhibitor heavy chain H1target
ZincInter-alpha-trypsin inhibitor heavy chain H2target
ZincInter-alpha-trypsin inhibitor heavy chain H3target
ZincInter-alpha-trypsin inhibitor heavy chain H4target
ZincImmunoglobulin J chaintarget
ZincJunction plakoglobintarget
ZincPlasma kallikreintarget
ZincKeratin, type II cytoskeletal 1target
ZincKeratin, type I cytoskeletal 10target
ZincKeratin, type I cytoskeletal 14target
ZincKeratin, type I cytoskeletal 16target
ZincKeratin, type II cytoskeletal 2 epidermaltarget
ZincKeratin, type II cytoskeletal 5target
ZincKeratin, type II cytoskeletal 6Atarget
ZincKeratin, type I cytoskeletal 9target
ZincAlpha-1-acid glycoprotein 2target
ZincN-acetylmuramoyl-L-alanine amidasetarget
ZincSerum paraoxonase/arylesterase 1target
ZincPregnancy zone proteintarget
ZincProtein S100-A7target
ZincSelenoprotein Ptarget
ZincCorticosteroid-binding globulintarget
ZincHeparin cofactor 2target
ZincSex hormone-binding globulintarget
ZincAmyloid-like protein 1target
ZincAmyloid-like protein 2target
ZincAmyloid beta A4 proteintarget
ZincPoly [ADP-ribose] polymerase 1target
ZincCarbonic anhydrase 1enzyme
ChromiumCytochrome b5target
TetrathiomolybdateAmyloid beta A4 proteintarget
Gallium nitrateSerotransferrincarrier
Gallium nitrateRibonucleoside-diphosphate reductase subunit M2target
Gallium nitrateV-type proton ATPase subunit B, brain isoformtarget
Cupric ChlorideVitamin K-dependent protein Ctarget
Cupric ChlorideCystatin-Btarget
Ferric pyrophosphateFerritin light chaintarget
Ferric pyrophosphateHemoglobin subunit alphatarget
Ferric pyrophosphateHemoglobin subunit betatarget
Strontium chloride Sr-89Alkaline phosphatase, germ cell typeenzyme
Strontium chloride Sr-89Alkaline phosphatase, tissue-nonspecific isozymeenzyme
Strontium chloride Sr-89Adenosine triphosphate (ATP)enzyme
Strontium chloride Sr-89Sodium/calcium exchanger 1transporter
Strontium chloride Sr-89Voltage-dependent T-type calcium channel subunit alpha-1Itransporter
Cupric oxideSerum albumincarrier
Cupric oxideCeruloplasmincarrier
Gallium Ga-68 gozetotideProstate-specific antigentarget