This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Echinacea
DrugBank Accession Number
DB14240
Background

Not Available

Type
Biotech
Groups
Approved, Experimental
Synonyms
  • Echinacea angustifolia or echinacea pallida
  • Echinacea, unspecified

Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AbemaciclibThe metabolism of Abemaciclib can be increased when combined with Echinacea.
AcalabrutinibThe metabolism of Acalabrutinib can be increased when combined with Echinacea.
AcenocoumarolThe metabolism of Acenocoumarol can be increased when combined with Echinacea.
AlbendazoleThe metabolism of Albendazole can be increased when combined with Echinacea.
AlectinibThe metabolism of Alectinib can be increased when combined with Echinacea.
AlpelisibThe metabolism of Alpelisib can be increased when combined with Echinacea.
AminophyllineThe metabolism of Aminophylline can be increased when combined with Echinacea.
AmiodaroneThe metabolism of Amiodarone can be increased when combined with Echinacea.
AstemizoleThe metabolism of Astemizole can be increased when combined with Echinacea.
AtazanavirThe metabolism of Atazanavir can be increased when combined with Echinacea.
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Food Interactions
No interactions found.

Products

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Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
EchinaceaCapsule500 mg / capOralNutraceutical CorporationNot applicableNot applicableCanada flag
Echinacea - LiqLiquid1 g / mLOralSisu Inc.1995-12-312004-09-01Canada flag
Echinacea Capsules 400mgCapsule400 mg / capOralMczand Herbal Inc.1995-12-311996-11-13Canada flag
Echinacea PlusCapsule1000 mg / capOralSisu Inc.1998-11-102004-09-01Canada flag
Echinacea TinctureSolution / drops307.5 mg / mLOralSt. Francis Herb Farm Inc.1989-12-311997-04-07Canada flag
Echinacea TinctureTincture200 mg / mLOralHolista Health (Canada) Inc.1997-07-142002-08-06Canada flag
EchinaceeCapsule1000 mgOralSantÉ Naturelle (Ag) LtÉe1999-03-192007-08-03Canada flag
EchinaceeCapsule1000 mgOralPns Pharma Therapy2001-09-302009-08-05Canada flag
EchinalifeCapsule325 mg / capOralHolista Health (Canada) Inc.1996-12-312001-08-01Canada flag
Premium EchinaceaCapsule500 mg / capOralHolista Health (Canada) Inc.1997-07-142003-07-30Canada flag
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Celestial Seasonings Herbal Comfort LozengesEchinacea (50 mg / loz) + Eleuthero (25 mg / loz)LozengeOralWarner Lambert Canada Inc.Not applicableNot applicableCanada flag
Echinacea With Goldenseal RootEchinacea (225 mg / cap) + Echinacea (225 mg / cap) + Goldenseal (50 mg / cap)CapsuleOralAu Naturel, Inc.Not applicableNot applicableCanada flag
Echinacea With Goldenseal RootEchinacea (225 mg / cap) + Echinacea (225 mg / cap) + Goldenseal (50 mg / cap)CapsuleOralAu Naturel, Inc.Not applicableNot applicableCanada flag
Ethical Herbals Sore Throat/cough/cold DefenseEchinacea (125 mg / tab) + Goldenseal (12.5 mg / tab)TabletOralAshbury Research CorporationNot applicableNot applicableCanada flag
Herbon Sugar Free Wild CherryEchinacea (100 mg/1) + Menthol (2 mg/1)LozengeOralPurity Life Division of SunOpta Co.2009-09-302010-12-31US flag
Herbon Wild CherryEchinacea (100 mg/1) + Menthol (2 mg/1)LozengeOralPurity Life Division of SunOpta2009-09-30Not applicableUS flag

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
4N9P6CC1DX
CAS number
Not Available

References

General References
Not Available
RxNav
228041
Wikipedia
Echinacea

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4CompletedNot AvailableHealthy Subjects (HS)1
4CompletedPreventionCommon Cold / Coronavirus Disease 2019 (COVID‑19) / Recurrent Upper and Lower Respiratory Tract Infections (RTIs)1
4CompletedPreventionInfection1
4CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections1
4RecruitingTreatmentCoronavirus Disease 2019 (COVID‑19)1
3CompletedPreventionCommon Cold / Gastroenteritis1
3CompletedTreatmentCommon Cold1
3CompletedTreatmentPharyngitis1
2CompletedPreventionCommon Cold1
2WithdrawnSupportive CareMucositis / Recurrent Squamous Cell Carcinoma of the Hypopharynx / Recurrent Squamous Cell Carcinoma of the Larynx / Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity / Recurrent Squamous Cell Carcinoma of the Nasopharynx / Recurrent Squamous Cell Carcinoma of the Oropharynx / Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity / Recurrent Verrucous Carcinoma of the Larynx / Recurrent Verrucous Carcinoma of the Oral Cavity / Stage III Squamous Cell Carcinoma of the Hypopharynx / Stage III Squamous Cell Carcinoma of the Larynx / Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity / Stage III Squamous Cell Carcinoma of the Nasopharynx / Stage III Squamous Cell Carcinoma of the Oropharynx / Stage III Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity / Stage III Verrucous Carcinoma of the Larynx / Stage III Verrucous Carcinoma of the Oral Cavity / Stage IV Squamous Cell Carcinoma of the Hypopharynx / Stage IV Squamous Cell Carcinoma of the Nasopharynx / Stage IVA Squamous Cell Carcinoma of the Larynx / Stage IVA Squamous Cell Carcinoma of the Lip and Oral Cavity / Stage IVA Squamous Cell Carcinoma of the Oropharynx / Stage IVA Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity / Stage IVA Verrucous Carcinoma of the Larynx / Stage IVA Verrucous Carcinoma of the Oral Cavity / Stage IVB Squamous Cell Carcinoma of the Larynx / Stage IVB Squamous Cell Carcinoma of the Lip and Oral Cavity / Stage IVB Squamous Cell Carcinoma of the Oropharynx / Stage IVB Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity / Stage IVB Verrucous Carcinoma of the Larynx / Stage IVB Verrucous Carcinoma of the Oral Cavity / Tongue Cancers1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
LozengeOral
LozengeOral50 mg / loz
LiquidOral1 g / mL
CapsuleOral400 mg / cap
LiquidOral500 mg / mL
CapsuleOral1000 mg / cap
LozengeOral500 mg / loz
Solution / dropsOral307.5 mg / mL
TinctureOral200 mg / mL
CapsuleOral
CapsuleOral1000 mg
CapsuleOral325 mg / cap
TabletOral200 mg / tab
TabletOral166 mg / tab
TabletOral
CapsuleOral500 mg / cap
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available

Enzymes

Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Inducer
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da
References
  1. Awortwe C, Manda VK, Avonto C, Khan SI, Khan IA, Walker LA, Bouic PJ, Rosenkranz B: Echinacea purpurea up-regulates CYP1A2, CYP3A4 and MDR1 gene expression by activation of pregnane X receptor pathway. Xenobiotica. 2015 Mar;45(3):218-29. doi: 10.3109/00498254.2014.973930. Epub 2014 Nov 7. [Article]
  2. Gorski JC, Huang SM, Pinto A, Hamman MA, Hilligoss JK, Zaheer NA, Desai M, Miller M, Hall SD: The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo. Clin Pharmacol Ther. 2004 Jan;75(1):89-100. doi: 10.1016/j.clpt.2003.09.013. [Article]

Drug created at July 05, 2018 16:04 / Updated at August 09, 2022 10:05