This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Echinacea
- DrugBank Accession Number
- DB14240
- Background
Not Available
- Type
- Biotech
- Groups
- Approved, Experimental
- Synonyms
- Echinacea angustifolia or echinacea pallida
- Echinacea, unspecified
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Contraindications & Blackbox Warnings
Avoid life-threatening adverse drug eventsImprove clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events & improve clinical decision support.- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAbemaciclib The metabolism of Abemaciclib can be increased when combined with Echinacea. Acalabrutinib The metabolism of Acalabrutinib can be increased when combined with Echinacea. Acenocoumarol The metabolism of Acenocoumarol can be increased when combined with Echinacea. Albendazole The metabolism of Albendazole can be increased when combined with Echinacea. Alectinib The metabolism of Alectinib can be increased when combined with Echinacea. Alpelisib The metabolism of Alpelisib can be increased when combined with Echinacea. Aminophylline The metabolism of Aminophylline can be increased when combined with Echinacea. Amiodarone The metabolism of Amiodarone can be increased when combined with Echinacea. Astemizole The metabolism of Astemizole can be increased when combined with Echinacea. Atazanavir The metabolism of Atazanavir can be increased when combined with Echinacea. 
Identify potential medication risksEasily compare up to 40 drugs with our drug interaction checker.Get severity rating, description, and management advice.Learn more - Food Interactions
- No interactions found.
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Echinacea Capsule 500 mg / cap Oral Nutraceutical Corporation Not applicable Not applicable Canada 
Echinacea - Liq Liquid 1 g / mL Oral Sisu Inc. 1995-12-31 2004-09-01 Canada Echinacea Capsules 400mg Capsule 400 mg / cap Oral Mczand Herbal Inc. 1995-12-31 1996-11-13 Canada Echinacea Plus Capsule 1000 mg / cap Oral Sisu Inc. 1998-11-10 2004-09-01 Canada Echinacea Tincture Solution / drops 307.5 mg / mL Oral St. Francis Herb Farm Inc. 1989-12-31 1997-04-07 Canada Echinacea Tincture Tincture 200 mg / mL Oral Holista Health (Canada) Inc. 1997-07-14 2002-08-06 Canada Echinacee Capsule 1000 mg Oral SantÉ Naturelle (Ag) LtÉe 1999-03-19 2007-08-03 Canada Echinacee Capsule 1000 mg Oral Pns Pharma Therapy 2001-09-30 2009-08-05 Canada Echinalife Capsule 325 mg / cap Oral Holista Health (Canada) Inc. 1996-12-31 2001-08-01 Canada Premium Echinacea Capsule 500 mg / cap Oral Holista Health (Canada) Inc. 1997-07-14 2003-07-30 Canada - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Celestial Seasonings Herbal Comfort Lozenges Echinacea (50 mg / loz) + Eleuthero (25 mg / loz) Lozenge Oral Warner Lambert Canada Inc. Not applicable Not applicable Canada Echinacea With Goldenseal Root Echinacea (225 mg / cap) + Echinacea (225 mg / cap) + Goldenseal (50 mg / cap) Capsule Oral Au Naturel, Inc. Not applicable Not applicable Canada Echinacea With Goldenseal Root Echinacea (225 mg / cap) + Echinacea (225 mg / cap) + Goldenseal (50 mg / cap) Capsule Oral Au Naturel, Inc. Not applicable Not applicable Canada Ethical Herbals Sore Throat/cough/cold Defense Echinacea (125 mg / tab) + Goldenseal (12.5 mg / tab) Tablet Oral Ashbury Research Corporation Not applicable Not applicable Canada Herbon Sugar Free Wild Cherry Echinacea (100 mg/1) + Menthol (2 mg/1) Lozenge Oral Purity Life Division of SunOpta Co. 2009-09-30 2010-12-31 US 
Herbon Wild Cherry Echinacea (100 mg/1) + Menthol (2 mg/1) Lozenge Oral Purity Life Division of SunOpta 2009-09-30 Not applicable US
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 4N9P6CC1DX
- CAS number
- Not Available
References
Clinical Trials
- Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Lozenge Oral Lozenge Oral 50 mg / loz Liquid Oral 1 g / mL Capsule Oral 400 mg / cap Liquid Oral 500 mg / mL Capsule Oral 1000 mg / cap Lozenge Oral 500 mg / loz Solution / drops Oral 307.5 mg / mL Tincture Oral 200 mg / mL Capsule Oral Capsule Oral 1000 mg Capsule Oral 325 mg / cap Tablet Oral 200 mg / tab Tablet Oral 166 mg / tab Tablet Oral Capsule Oral 500 mg / cap - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
Enzymes
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Inducer
- General Function
- Vitamin d3 25-hydroxylase activity
- Specific Function
- Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
- Gene Name
- CYP3A4
- Uniprot ID
- P08684
- Uniprot Name
- Cytochrome P450 3A4
- Molecular Weight
- 57342.67 Da
References
- Awortwe C, Manda VK, Avonto C, Khan SI, Khan IA, Walker LA, Bouic PJ, Rosenkranz B: Echinacea purpurea up-regulates CYP1A2, CYP3A4 and MDR1 gene expression by activation of pregnane X receptor pathway. Xenobiotica. 2015 Mar;45(3):218-29. doi: 10.3109/00498254.2014.973930. Epub 2014 Nov 7. [Article]
- Gorski JC, Huang SM, Pinto A, Hamman MA, Hilligoss JK, Zaheer NA, Desai M, Miller M, Hall SD: The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo. Clin Pharmacol Ther. 2004 Jan;75(1):89-100. doi: 10.1016/j.clpt.2003.09.013. [Article]
Drug created at July 05, 2018 16:04 / Updated at September 28, 2023 01:14