Common Cold (DBCOND0000353)

Identifiers

Synonyms
Common cold / Common cold syndrome / Rhinitis infective / Rhinitis (infective) / Infective rhinitis / Acute rhinitis / Head cold / Cold / Acute nasopharyngitis (common cold) / Acute nasopharyngitis / Common cold (disorder) / Nasopharyngitis / Nasopharyngitis (disorder) / Rhinopharyngitis

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Acetaminophen
An analgesic drug used alone or in combination with opioids for pain management, and as an antipyretic agent.
Acetylsalicylic acid
A salicylate used to treat pain, fever, inflammation, migraines, and reducing the risk of major adverse cardiovascular events.
Ammonium chloride
Expectorant in cough syrups. The ammonium ion (NH4+) in the body plays an important role in the maintenance of acid-base balance. The kidney uses ammonium (NH4+) in place of sodium...
No drug targets
Ascorbic acid
A vitamin used to correct vitamin C deficiency and to increase the intestinal absorption of iron.
Bromhexine
A mucolytic drug used to decrease the viscosity of mucus in the airway, enhancing mucus clearance.
Brompheniramine
A histamine H1 antagonist used to treat coughs, upper respiratory symptoms, and nasal congestion associated with allergies and the common cold.
Caffeine
A stimulant present in tea, coffee, cola beverages, analgesic drugs, and agents used to increase alertness. It is also used in to prevent and treat pulmonary complications of premature birth.
Camphor
A compound used topically to help relieve pain and also as a topical antiseptic. May also be used in vaporizers to help suppress coughing. This medication should not be swallowed.
Chlorcyclizine
Chlorcyclizine is a first generation phenylpiperazine class antihistamine used to treat urticaria, rhinitis, pruritus, and other allergy symptoms. Chlorcyclizine also has some local anesthetic, anticholinergic, and antiserotonergic properties, and can...
Chlorpheniramine
A histamine-H1 receptor antagonist indicated for the management of symptoms associated with upper respiratory allergies.
Choline salicylate
The oral gel is indicated for the relief of pain and discomfort of common mouth ulcers, cold sores, denture sore spots, infant teething and mouth ulcers, and sore spots due...
Clemastine
An antihistamine with sedative and anticholinergic effects used to treat the symptoms of allergic rhinitis.
Codeine
An opioid analgesic used to treat moderate to severe pain when the use of an opioid is indicated.
DL-Methylephedrine
Used as an antitussive and decongestant .
Desloratadine
A second generation tricyclic antihistamine used to treat seasonal and non seasonal allergic rhinitis, pruritus, and urticaria.
Dexchlorpheniramine
A chlorpheniramine enantiomer antihistamine indicated in the treatment of sunburns, insect bites, and allergic reactions of the skin.
Dexchlorpheniramine maleate
A first generation antihistamine used to treat allergic and vasomotor rhinitis, allergic conjunctivitis, and mild urticaria and angioedema.
Dextromethorphan
An NMDA receptor antagonist used to treat cases of dry cough.
Diclofenac
An NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis.
Dimetindene
A 1st generation selective H1 antagonist used topically as an antipruritic and orally to treat allergies.
Diphenhydramine
A H1 receptor antihistamine used in the treatment of seasonal allergies, and various allergic reactions including sneezing, runny nose, itchy/watery eyes, itching of nose or throat, pruritus, urticaria, insect bites/stings, and allergic rashes.
Doxylamine
An antihistamine used to treat insomnia and allergy symptoms and is used with pyridoxine in the treatment of nausea and vomiting in pregnancy.
Ephedrine
An alpha and beta-adrenergic agonist indicated to treat hypotension under anesthesia, allergic conditions, bronchial asthma, and nasal congestion.
Ethyl nitrite
An ingredient in cough syrups for symptomatic treatment of cough, cold, bronchitis, and phlegm.
No drug targets
Ethylmorphine
An opioid analgesic and antitussive agent used to reduce coughs caused by colds and lung infections in combination with codeine.
Eucalyptus oil
An ingredient used in a variety of natural health products.
No drug targets
Guaifenesin
An expectorant commonly found in OTC products for the symptomatic relief from congested chests and coughs associated with cold, bronchitis, and/or other breathing illnesses.
Ibuprofen
An NSAID and non-selective COX inhibitor used to treat mild-moderate pain, fever, and inflammation.
Isopropamide
A long-acting anticholinergic drug used to relieve symptoms of spastic and painful symptoms of gastrointestinal conditions and symptoms of flu, colds, and related conditions.
Levocetirizine
An H1-receptor antagonist used to treat symptoms associated with chronic allergic rhinitis and uncomplicated cases of chronic idiopathic urticaria.
Levomenthol
An organic compound used to treat mild to moderate muscle and joint pain.
Loratadine
A second generation antihistamine used to manage the symptoms of allergic rhinitis.
Mepyramine
An antihistamine agent used for the symptomatic treatment of allergy, hypersensitivity reactions, and pruritic skin disorders.
Noscapine
A non-sedating isoquinoline alkaloid used primarily for its antitussive properties.
Pelargonium sidoides root
A plant product used to treat the common cold.
No drug targets
Pentoxyverine
A medication used to suppress a cough in the common cold, flu, bronchitis, and sinusitis.
Pheniramine
An antihistamine used to treat allergic rhinitis and pruritus.
Phenylephrine
An alpha-1 adrenergic agonist used in the management of hypotension, generally in the surgical setting associated with the use of anesthetics.
Phenylpropanolamine
A sympathomimetic that was previously used in nasal decongestants and weight loss products, but has been withdrawn by the FDA due to safety risks and lack of efficacy.
Promethazine
A first-generation antihistamine used for the treatment of allergic conditions, nausea and vomiting, and motion sickness.
Pseudoephedrine
An alpha and beta adrenergic agonist used to treat nasal and sinus congestion, as well as allergic rhinitis.
Pyridoxine
A vitamin used to correct vitamin B6 deficiency and to treat nausea during pregnancy.
Sodium ascorbate
Not Available
No drug targets
Sodium citrate
An ingredient used for the anticoagulation of whole blood as part of automated apheresis procedures.
Terpineol
An ingredient in products that are adjunct in the treatment of upper respiratory tract congestion.
No drug targets
Triprolidine
A sedating antihistamine combined with pseudoephedrine and guaifenesin in various types of cold and allergy medications to relieve allergy symptoms, hay fever and common cold symptoms, and to aid in sleep.
Zinc
An essential element commonly used for the treatment of patients with documented zinc deficiency.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT02822287
Warming Sensation and Tolerability Study of Acetylcysteine 2% Oral Solution for Productive CoughNo drug interventionstreatment3completed
NCT03474887
Digital Online Consultations - Effects on Antibiotic Prescribing and Health Care Utilization in Primary CareNo drug interventionsNot AvailableNot Availablecompleted
NCT01883453
A Nasal Spray With Glucose Oxidase as a Treatment of Common ColdNo drug interventionstreatment2completed
NCT05034328
Symbiofilm Trial in Allergic Kids (SYMBIOFILM-TAK)No drug interventionsNot AvailableNot Availablecompleted
NCT00029211
A Trial of Echinacea in Childrentreatment3completed
NCT00405509
The Natural History of Viral Upper Respiratory Infections in Children Aged 6 to Less Than 14 YearsNo drug interventionsNot AvailableNot Availablecompleted
NCT01964885
Benefit and Tolerability of IQP-AS-105 in Reducing Susceptibility to Upper Respiratory Tract InfectionsNo drug interventionsprevention3terminated
NCT01651715
Efficacy and Safety Study of Homeopathic Oral Antibodies to Treat Viral Upper Respiratory Tract InfectionsNo drug interventionstreatment1 / 2completed
NCT01677715
Study of Yili Mei Yi Tian Active Lactobacillus Drink to Improve Immunity and Digestive SystemNo drug interventionspreventionNot Availablecompleted
NCT03189537
Study of Post-Exposure Ingavirin® Prophylaxis of Influenza and Acute Respiratory Viral Infectionsprevention3completed
NCT01459952
A Double-blind, Randomised, Parallel Group,Comparative Study With Rose-hip Liquid and Placebo Given to Healthy Volunteers in the Winter Season Aiming to Evaluate the Occurences of Flu and Catching a ColdNo drug interventionsprevention3completed
NCT06315400
Efficacy and Safety of Ingavirin®, Capsules, 60 mg, in Children With Influenza and Other Acute Respiratory Viral Infectionstreatment4recruiting
NCT00032500
Evaluation of Echinacea for the Common Coldprevention2completed
NCT02778100
A Study of Nasal Glucagon in Participants With a Common Coldbasic_science1completed
NCT00452270
Decongestant Effect, Timing of Effect and Impact on Sleep and General Well-Being of Xylometazoline in Subjects With a Common Coldtreatment3completed
NCT05640570
The Preventive Effectiveness of the Individualized Jade Wind-Barrier Herbal Tea Bag on the Common Cold in Elderly With Qi-deficiency Constitution (CCJWBT): A Pragmatic Randomized Controlled TrialNo drug interventionsprevention2completed
NCT02535442
Nasal Swab Study to Explore the Nasal MicrobiaNo drug interventionsNot AvailableNot Availablecompleted
NCT02522949
Evaluation of ColdZyme® Mouth Spray on Prevention and Alleviation of Rhinovirus Induced Common ColdNo drug interventionstreatmentNot Availablecompleted
NCT02957136
Rapid Diagnostics for Upper Respiratory Infections in the Emergency DepartmentNo drug interventionshealth_services_researchNot Availablecompleted
NCT00940836
Efficacy and Safety Assessment of an Anti-Cold Preparation in the Symptomatic Treatment of Common Cold and Flu-Like Syndrometreatment3unknown_status
NCT05960318
Post Market Clinical Follow-Up Study - Medical Device KalobaNasoNo drug interventionsNot AvailableNot Availablecompleted
NCT02644018
Efficacy and Safety Study of Ingavirin® to Treat Influenza and Other Acute Respiratory Viral Infections in Patients 3-6 y.o.treatment3completed
NCT00231218
Echinacea, Propolis and Vitamin C for URI Prevention in Preschoolersprevention3completed
NCT05273619
Efficacy and Safety of XC8, Film-coated Tablets, 40 mg in Patients With Dry Non-productive Cough Against Acute Respiratory Viral InfectionNo drug interventionstreatment3completed
NCT03831763
Evaluation of the Use of Various Assessments of Common Cold Symptoms for Proof of Efficacy of ColdZyme Mouth SprayNo drug interventionstreatmentNot Availablecompleted
NCT01092039
Safety and Efficacy Study of Oral XIGO Tablets to Treat The Common ColdNo drug interventionstreatmentNot Availablecompleted
NCT05556148
Otrivine: Quality of Life (QoL) Impact in a Real-World Settingtreatment4completed
NCT01944631
Iota-Carrageenan Nasal Spray in Common ColdNo drug interventionstreatment4completed
NCT00655031
Trial to Evaluate the Use of Pomegranate Concentrate (POMx) for the Prevention of Experimental Rhinovirus InfectionNo drug interventionsprevention2completed
NCT04144491
Effect of L. Rhamnosus Yoba on RTI and Other Health Outcomes Among Children (3-6 Years) in UgandaNo drug interventionspreventionNot Availablecompleted
NCT02832362
Local Nasal Tolerability and Safety Study of 1146A in Healthy Adult Participantsother1completed
NCT06106880
Alleviation of Common Cold Symptomstreatment1completed
NCT02660489
Effect of OC459 on the Response to Rhinovirus Challenge in Asthmatreatment2completed
NCT03005067
To Evaluate the Efficacy and Safety of 1146A Nasal Spray in Adult Participants With Symptoms of Common Coldtreatment2completed
NCT04681001
Prophylactic Treatment With Carragelose Nasal Spary to Prevent SARS-CoV-2, COVID-19, Infections in Health Care WorkersNo drug interventionspreventionNot Availablecompleted
NCT01488604
A Study of an Experimental Nasal Spray in Subjects With Early Signs of the Common ColdNo drug interventionstreatmentNot Availablecompleted
NCT03901846
Duration of ColdZyme® IINo drug interventionsotherNot Availablecompleted
NCT01277081
Effect of Paracetamol on the Common Coldtreatment2completed
NCT00448981
Stopping Upper Respiratory Infections and Flu in the Family: The Stuffy TrialNo drug interventionspreventionNot Availablecompleted
NCT03070314
Echinaforce Junior Bioavailability TrialNo drug interventionsbasic_science4withdrawn
NCT00394914
Effects of Pleconaril Nasal Spray on Common Cold Symptoms and Asthma Exacerbations Following Rhinovirus Exposure (Study P04295)prevention2completed
NCT02656914
Efficacy and Safety of Irlanda-2 Association on the Treatment of Common ColdNo drug interventionstreatment3withdrawn
NCT02479750
Evaluation of ColdZyme® on Experimentally Induced Common Cold.No drug interventionstreatmentNot Availablecompleted
NCT05070650
Efficacy and Safety of the Combination of Acetylcysteine, Paracetamol and Phenylephrine for the Treatment of Common Coldtreatment3not_yet_recruiting
NCT03683108
Efficacy and Safety of Resveratrol and Carbossimetyl Beta Glucan in Treatment of Upper Airways Disease in Infancytreatment3completed
NCT03415243
To Investigate the Gastrointestinal Behaviour of Two Triple Combination Products in Healthy Male Volunteerstreatment1completed
NCT00963443
Acetylsalicylic Acid Combined With Pseudoephedrine in Common Coldtreatment3completed
NCT01669603
Effect of Probiotic on the Innate and Adaptive Host Response to Rhinovirus (EPIARR)No drug interventionsbasic_scienceNot Availablecompleted
NCT05819203
BАbykids Spray In Common ColdNo drug interventionstreatmentNot Availablecompleted
NCT05819190
Testing the Efficacy in Adults With Cold of HEalsea Rescue*No drug interventionstreatmentNot Availablecompleted
NCT01728090
Effectiveness of a Handwashing Programme in the Prevention of School Absenteeism Due to Respiratory InfectionsNo drug interventionsprevention4completed
NCT01677702
Study of Yili Lactoferrin ShuHua Milk in the Improvement of Human ImmunizationNo drug interventionspreventionNot Availablecompleted
NCT02438579
Hypertonic Saline Nasal Irrigation and Gargling for the Common Cold.No drug interventionssupportive_careNot Availablecompleted
NCT02174653
Safety and Intake Effect of EPs® 7630 (an Extract of the Roots of Pelargonium Sidoides)Not Available3completed
NCT02981147
PEACe: Ivy, Thyme and Cisti Extract (Phytus) Efficacy in Acute CoughNo drug interventionstreatment4completed
NCT05944705
Commercially Available Cannabis Products for Immune SupportNo drug interventionsNot AvailableNot Availablerecruiting
NCT03191097
Efficacy and Safety Study of Ingavirin® to Treat Influenza and Acute Respiratory Viral Infections in Children 7-12 y.o.treatment3completed
NCT04073511
Herbal Medicine 'Eungyosan' and 'Samsoeum' for Common ColdNo drug interventionstreatmentNot Availableunknown_status
NCT01332578
A Comparison of Solid and Soluble Forms of Cold and Influenza RemediesNot Available4completed
NCT02656888
Efficacy and Safety of Irlanda-1-Association on the Treatment of Common Cold in ChildrenNo drug interventionstreatment3withdrawn
NCT05126407
A Study of Olynth Saline/Ectomed Nasal Drops/Spray Based Upon Previous UsageNo drug interventionsNot AvailableNot Availablecompleted
NCT02679807
Effect of Probiotic on Rhinovirus Induced ColdsNo drug interventionspreventionNot Availablecompleted
NCT06531707
Efficacy and Safety in the Combination of Ibuprofen / Loratadine Versus Ibuprofen Versus Loratadinetreatment3recruiting
NCT04326309
Audio Data Collection for Identification and Classification of CoughingNo drug interventionsNot AvailableNot Availablecompleted
NCT01465009
Placebo and Active Controlled Study to Compare the Efficacy of Aspirin and Paracetamol in Treatment of Sore Throat Associated With a Common Coldtreatment4completed
NCT00065715
Echinacea Versus Placebo Effect in Common Cold (Physician Echinacea Placebo)No drug interventionstreatment3completed
NCT03154515
Efficacy and Safety Study of Ingavirin® 90 mg Once Daily to Treat Influenza and Other Acute Viral Infections in Adultstreatment4completed
NCT06005337
Supporting Parents to Choose WiselyNo drug interventionsotherNot Availableactive_not_recruiting
NCT00299559
Kinetics of Etheric Oils, Smart Textiles vs. Ointmenttreatment1completed
NCT00967759
Study Comparing 3 Formulations to Evaluate the Efficacy and Safety of the Inflammatory Symptoms of the Upper Respiratory Tract, in Children Between 2 and 6 Years OldNo drug interventionstreatment3withdrawn
NCT00993759
Efficacy Study of A Lotion to Prevent Common ColdsNo drug interventionsprevention2unknown_status
NCT04943575
Study to Evaluate the Efficacy of EZC Pak in Adults With Upper Respiratory Infection (URI)No drug interventionstreatmentNot Availablecompleted
NCT01257542
Acute Cough Study In Childrentreatment4terminated
NCT01361399
Active and Placebo Controlled Study to Test the Efficacy and Safety of an Aspirin-Lidocaine Lozenge in the Symptomatic Treatment of Sore Throat Associated With a Common Coldtreatment3completed
NCT04533906
Study to Investigate if Sucking a Coldamaris Lozenge Elutes Sufficient Iota-carrageenan to Inactivate Usual Common Cold VirusesNo drug interventionstreatmentNot Availablecompleted
NCT01046136
Mucinex Exploratory Cold Studytreatment2completed
NCT00617318
Pomegranate Products for Prevention of Common ColdNo drug interventionsprevention3completed
NCT06278324
Effectiveness of a Nasal Spray on Viral Respiratory InfectionsNo drug interventionstreatmentNot Availablerecruiting
NCT02451163
DBRCT on the Effect of Wheat Polysaccharides on Common Cold Infections in ElderlyNo drug interventionsprevention2completed
NCT06497439
Efficacy and Safety of Silfamin for Common ColdNo drug interventionstreatment2not_yet_recruiting
NCT00778648
Encapsulated Juice Powder Concentrate for Preventing Common Cold SymptomsNo drug interventionspreventionNot Availablecompleted
NCT05244148
Two Seawater-based Formulations for Relief of Nasal Congestion in Paediatric SubjectsNo drug interventionstreatmentNot Availablerecruiting
NCT01466348
Effects of a Common Cold Treatment on Cognitive Functiontreatment4completed
NCT01158326
Evaluation of Efficacy and Safety of Oral Solution Resfenol in Reducing Symptoms of Common Cold And FluNo drug interventionstreatment3completed
NCT01033526
Symptomatic Treatment of Common Cold Symptomstreatment4completed
NCT03339726
Randomized, Double-blind, Placebo-Controlled, Efficacy Study of a New Formulation of Phenylephrine HCL in the Common Coldtreatment2terminated
NCT02246166
The Effect of Paracetamol, Pseudoephedrine Hydrochloride, Dextromethorphan Hydrobromide and Chlorpheniramine Maleate Tablets Compared to Placebo in Subjects Suffering From the Common Cold or Influenza.No drug interventionstreatment4completed
NCT00358774
Efficacy of Homeopathic Nasal Formulation for Management of Experimental Rhinoviral ColdsNo drug interventionsprevention1 / 2completed
NCT04368520
Clinical Trial to Optimise Levels of Vitamin D for Rhinovirus ProtectionNo drug interventionsprevention2withdrawn
NCT00762476
Efficacy Trial of 3804-250A in the Prevention of Cold IllnessesNo drug interventionsprevention2completed
NCT01062360
Placebo and Active Controlled Study to Assess Efficacy and Tolerability of Aspirin Plus Pseudoephedrinetreatment3completed
NCT00480194
Evaluation of Safety of ZyComb® In Patients With Common Cold - ZIP 3000 (XY-005-IM)Not AvailableNot Availablecompleted
NCT05269329
Efficacy and Safety of XC8, Film-coated Tablets, 10 mg in Patients With Dry Non-productive Cough Against Acute Respiratory Viral InfectionNo drug interventionstreatment2completed
NCT01938144
Evaluation of the Efficacy and Safety of Two Ibuprofen Combination Products for the Treatment of the Common Cold and Flu in Latin Americatreatment3withdrawn
NCT00378144
Efficacy and Safety of Sinutab on Subjects in the Setting of a Common Coldtreatment4completed
NCT01883440
Glucose Oxidase as Treatment Against Common Coldtreatment2completed
NCT01823640
Experimental Human Rhinovirus InfectionNo drug interventionsbasic_science1completed
NCT03794804
Double-blind, Randomized, Parallel-group, Placebo-controlled Study to Evaluate Efficacy of CMS008618 for Common ColdNo drug interventionstreatmentNot Availablecompleted
NCT01686646
Effects of Two Doses of a Common Cold Treatment on Alertnesstreatment3completed
NCT03206346
Efficacy and Safety Study of Ingavirin® to Treat Influenza and Acute Respiratory Viral Infections in Patients 13-17 y.o.treatment3completed
NCT00552981
Effectiveness of Local Application of Warm Air in Patients With Common Cold (HELI Study)No drug interventionstreatmentNot Availablecompleted
NCT03309995
The Effect of Zinc Acetate Lozenges on the Rate of Recovery From the Common ColdNo drug interventionstreatmentNot Availablecompleted
NCT04672850
The Effect of Probiotic and Zinc Supplementation on the Common ColdNo drug interventionspreventionNot Availableunknown_status
NCT05269290
Efficacy and Safety of Ingavirin®, Syrup, 30 mg/5 ml, in Children With Influenza and Other Acute Respiratory Viral Infectionstreatment3completed
NCT05002179
Echinaforce Study to Investigate Explorative Pharmacology and Effectiveness to Prevent From Enveloped Virus Infectionsprevention4completed