Rebeccamycin

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DB14729InvestigationalSmall molecule

Rebeccamycin is a weak topoisomerase I inhibitor isolated from Nocardia sp.

Mechanism: Pharmacologically active on DNA topoisomerase 1 and DNA topoisomerase 2
Curator reviewed
Formula / weight: C₂₇H₂₁Cl₂N₃O₇ · 570.38 g/mol (avg)

Resolves to

Compound

UNIIY96MQM21V9CAS93908-02-2ChEMBLCHEMBL370100ChEBI135511

Structure

InChIKeyQEHOIJJIZXRMAN-QZQSLCQPSA-NSMILESCO[C@H]1[C@H](O)[C@@H](O)[C@@H](O[C@@H]1CO)N1C2=C(C3=C1C(Cl)=CC=C3)C1=C(C(=O)NC1=O)C1=C2NC2=C1C=CC=C2Cl

Targets

P11387TOP1

What you can answer from here — as of July 07, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

6Clinical trialsPhase, status and sponsor resolved per trial

9+ReferencesStructured and connected to the statements they support

Which drugs share a target with Rebeccamycin, and which of those have an active Phase 3 trial?

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