Indoles
- Name
- Indoles
- Accession Number
- DBCAT000528
- Description
Benzopyrroles with the nitrogen at the number one carbon adjacent to the benzyl portion, in contrast to ISOINDOLES which have the nitrogen away from the six-membered ring.
- Drugs
Drug Drug Description Mitomycin An antimetabolite used as an adjunct to ab externo (outside approach) eye surgeries for the treatment of glaucoma and used as a chemotherapeutic agent for various malignancies. Zolmitriptan A member of the triptan class of 5-HT(1B/1D/1F) receptor agonist drugs used for the acute treatment of migraine with or without aura in adults. Indomethacin A nonsteroidal anti-inflammatory (NSAID) used for symptomatic management of chronic musculoskeletal pain conditions and to induce closure of a hemodynamically significant patent ductus arteriosus in premature infants. Sumatriptan A serotonin receptor agonist used to treat migraines and cluster headaches. Perindopril An ACE inhibitor prodrug used to treat hypertension, mild to moderate congestive heart failure, and to reduce cardiovascular risk in patients with hypertension or post-myocardial infarction. Indapamide A thiazide diuretic used to treat hypertension as well as edema due to congestive heart failure. Tadalafil A phosphodiesterase 5 inhibitor used to treat erectile dysfunction, benign prostatic hyperplasia, and pulmonary arterial hypertension. Ondansetron A serotonin 5-HT3 receptor antagonist used to prevent nausea and vomiting in cancer chemotherapy and postoperatively. Melatonin An endogenous hormone produced by the pineal gland that regulates sleep-wake cycles and when provided exogenously has beneficial effects on sleep-onset latency; available as an over-the-counter supplement. Carvedilol A non selective beta-adrenergic antagonist used to treat mild to severe chronic heart failure, hypertension, and left ventricular dysfunction following myocardial infarction in clinically stable patients. Molindone An antipsychotic used to treat schizophrenia. Isatin Isatin is an indole derivative first obtained by Erdman and Laurent in 1841 as an oxidation product of Indigo dye with nitric acid and chromic acids. The compound is found... Oxyphenisatin A laxative that undergoes enterohepatic circulation. It may cause jaundice. Vilazodone An antidepressant agent used for the treatment of major depressive disorder that targets the 5-HT transporter and 5-HT1A receptors. Indigotindisulfonic acid A medication used to visualize ureteral orifices during cystoscopy and ureteral catheterization. Lurbinectedin A chemotherapeutic DNA alkylating agent used in the treatment of metastatic small-cell lung cancer. Metisazone Not Annotated Oxyphenisatin acetate Oxyphenisatin acetate is the pro-drug of oxyphenisatin (3,3-bis(4-hydroxyphenyl)-1H-indol-2-one). The FDA withdrew its approval for the use of oxyphenisatin acetate due to safety reasons. Fluvastatin An HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke. Sunitinib A receptor tyrosine kinase inhibitor and chemotherapeutic agent used for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). Panobinostat A non-selective histone deacetylase inhibitor used to treat multiple myeloma in combination with other antineoplastic agents. Vemurafenib A kinase inhibitor used to treat patients with Erdheim-Chester Disease who have the BRAF V600 mutation, and melanoma in patients who have the BRAF V600E mutation. Tropisetron A 5HT-3 receptor antagonist used as an antiemetic in the treatment of chemotherapy-induced nausea and vomiting. Indoxyl sulfate Not Available Flortaucipir F-18 A small lipophilic tracer containing [18F]fluoride capable of crossing the blood-brain barrier and binding to aggregated tau protein; used in PET imaging for the diagnosis of Alzheimer's disease. Indocyanine green A diagnostic agent for vascular imagine and radiography of the eye, as well as liver function tests. Indocyanine green acid form A diagnostic agent used for the determination of cardiac output, hepatic function and liver blood flow, and for ophthalmic angiography. Eletriptan A triptan used for the treatment of migraines. Delavirdine A non-nucleoside reverse transcriptase inhibitor used to treat HIV infection. Almotriptan A 5-HT1B/1D receptor agonist used to treat migraines. Naratriptan A 5-HT1B/1D receptor agonist used to treat migraines. Rizatriptan A 5-HT1B/1D receptor agonist used to treat migraines. Frovatriptan A 5-HT1B/1D receptor agonist used to treat migraines. Bufotenine A hallucinogenic serotonin analog found in frog or toad skins, mushrooms, higher plants, and mammals, especially in the brains, plasma, and urine of schizophrenics. Bufotenin has been used as a... Indopan Indopan (alpha-methyltryptamine) is a stimulant and psychoactive drug which produces effects similar to 3,4-methylenedioxy-N-methylamphetamine (MDMA), despite being structurally dissimilar. It was developed in the 1960's by Upjohn with the intention... Diethyltryptamine Diethyltryptamine (DET) is an orally active hallucinogenic agent and a substituted form of tryptamine. Dimethyltryptamine Some people use this compound as a psychedelic inducing agent. Etryptamine Developed in the 1960's for use as an antidepressant before market withdrawal in 1962. N-acetylserotonin Not Available Tryptamine Not Available Serotonin For temporary relief of nervousness, anxiety, mood swings, joint pains, weakness, drowsiness, itching and lethargy. Not evaluated by the FDA, homeopathic product. Indoramin Indoramin is a discontinued piperidine antiadrenergic drug with the trade names Baratol and Doralese. It is a selective alpha-1 adrenergic antagonist with no reflex tachycardia and direct myocardial depression action. Serdemetan Serdemetan has been used in trials studying the treatment of Neoplasms. Iprindole Not Annotated Reserpine For the treatment of hypertension Vindesine A vinca alkaloid derived from vinblastine used for various types of malignancies, but mainly acute lymphocytic leukemia (ALL). Vinorelbine A vinca alkaloid used in the treatment of metastatic non-small cell lung carcinoma (NSLC) and in conjunction with other drugs in locally advanced NSCLC. Vincristine A vinca alkaloid used to treat acute leukemia, malignant lymphoma, Hodgkin's disease, acute erythraemia, and acute panmyelosis. Vinblastine A vinca alkaloid used to treat breast cancer, testicular cancer, neuroblastoma, Hodgkin's and non-Hodgkins lymphoma, mycosis fungoides, histiocytosis, and Kaposi's sarcoma. Etodolac An NSAID used to treat osteoarthritis and rheumatoid arthritis, as well as acute pain. Carprofen For use as a pain reliever in the treatment of joint pain and post-surgical pain. Alosetron A 5-HT3 antagonist used to treat diarrhea-predominant IBS. Physostigmine A cholinesterase inhibitor used to treat glaucoma and anticholinergic toxicity. Deserpidine An alkaloid that has been used to manage hypertension. Rescinnamine For the treatment of hypertension. Yohimbine An alpha-2-adrenergic blocker and sympatholytic found in supplements used to. Ajmaline An antiarrhythmic used to manage a variety of forms of tachycardias. Almitrine For the treatment of chronic obstructive pulmonary disease. 5-Methoxy-N,N-diisopropyltryptamine 5-methoxy-N,N-diisopropyltryptamine (5-MeO-DIPT) is a tryptamine derivative and shares many similarities with schedule I tryptamine hallucinogens such as alpha-ethyltryptamine, N,N-dimethyltryptamine, N,N-diethyltryptamine, bufotenine, psilocybin and psilocin. Since 1999, there has been a... 7-Hydroxystaurosporine Not Available Staurosporine An indolocarbazole that is a potent protein kinase C inhibitor which enhances cAMP-mediated responses in human neuroblastoma cells. (Biochem Biophys Res Commun 1995;214(3):1114-20) K-252a Not Available Deacetoxyvinzolidine Not Available Lintitript For the treatment of pancreatic cancer and appetite disorders. Voacamine For the treatment of malaria. Also under investigation for the modulation of multidrug resistance in cancer cells. Edotecarin Clinical studies with edotecarin have shown activity in subjects with colorectal cancer, esophageal cancer and other solid tumors. Cilansetron For the treatment of symptoms associated with irritable bowel syndrome. Phenserine For the treatment of Alzheimer's disease (AD). Vintafolide Investigated for use/treatment in solid tumors. PTC299 Investigated for use/treatment in cancer/tumors (unspecified) and solid tumors. CEP-1347 Investigated for use/treatment in asthma and parkinson's disease. Becatecarin Investigated for use/treatment in cancer/tumors (unspecified), liver cancer, gastric cancer, and leukemia (unspecified). Lestaurtinib Investigated for use/treatment in pancreatic cancer, prostate cancer, and leukemia (myeloid). Porfiromycin Investigated for use/treatment in head and neck cancer. Midostaurin An antineoplastic agent used to treat high-risk acute myeloid leukemia (AML) with specific mutations, aggressive systemic mastocytosis (ASM), systemic mastocytosis with associated hematologic neoplasm (SM-AHN), or mast cell leukemia (MCL). Lidorestat Not Available Carbazole Not Available Harmine Not Available Indoleacetic acid Not Available N-(indole-3-acetyl)-L-aspartic acid Not Available Indoleacetamide Not Available Carbazochrome Indicated for capillary and parenchymal hemorrhage (trauma, tonsillectomy, during surgery), intestinal bleeding, and thrombocytopenic purpura. Pirlindole For the treatment of major depression. It is being studied in the treatment of fibromyalgia pain syndrome. One study determined that the effect of pirlindole on sensorimotor performance while driving... Metralindole Investigated for the treatment of depression. Rauwolfia serpentina root Rauwolfia alkaloids are indicated in the treatment of hypertension . Rauwolfia alkaloids have been used for relief of symptoms in agitated psychotic states such as schizophrenia; however, use as antipsychotics... Alectinib A kinase inhibitor used to treat anaplastic lymphoma kinase positive metastatic non small cell lung cancer. Metoserpate Not Annotated Vinflunine A vinca alkaloid used to treat advanced or metastatic transitional cell carcinoma of the urothelial tract after a platinum containing treatment has failed. Psilocybin Psilocybin has been investigated for the treatment of Anxiety and Stage IV Melanoma. In November, 2019, it was granted Breakthrough Therapy status by the FDA. OC-459 OC000459 is under investigation for the treatment of Severe Eosinophilic Asthma. OC000459 has been investigated for the treatment of Bronchial Asthma. Fevipiprant Fevipiprant has been used in trials studying the treatment of Asthma, Atopic Dermatitis, and Allergic Rhinitis. Orantinib Orantinib has been used in trials studying the treatment of Lung Cancer, Breast Cancer, Kidney Cancer, Gastric Cancer, and Prostate Cancer, among others. Vinpocetine A synthetic derivative of a vinca alkaloid used to treat neurological symptoms of cerebrovascular disease. Bizelesin Bizelesin has been used in trials studying the treatment of Unspecified Adult Solid Tumor, Protocol Specific. Apaziquone Apaziquone has been investigated for the treatment of Bladder Cancer and Bladder Neoplasms. TAK-901 TAK-901 has been used in trials studying the treatment of Lymphoma, Myelofibrosis, Multiple Myeloma, Myeloid Metaplasia, and Advanced Solid Tumors, among others. Pactimibe Pactimibe has been used in trials studying the treatment of Atherosclerosis and Coronary Heart Disease. Ramatroban Ramatroban has been used in trials studying the treatment of Asthma. Vincamine Vincamine is a monoterpenoid indole alkaloid obtained from the leaves of Vinca minor with a vasodilatory property. Studies indicate that vincamine increases the regional cerebral blood flow. Tenidap Not Annotated Proglumetacin A non-steroidal anti-inflammatory medication used to manage pain associated with various inflammatory conditions including rheumatoid arthritis and osteoarthritis. Iprazochrome Not Annotated Prajmaline Not Annotated Bietaserpine Not Annotated Lorajmine Not Annotated Acemetacin A NSAID indicated in the treatment of pain and inflammation. Vinburnine Not Annotated Mebhydrolin An antihistamine indicated in the treatment of allergies. Harmaline Not Annotated Selisistat Selective inhibitor of SIRT1 that does not inhibit histone deacetylase (HDAC) or other sirtuin deacetylase family members (IC50 values are 98, 19600, 48700, > 100000 and > 100000 nM for... 5-methoxy-N,N-dimethyltryptamine 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a tryptamine with psychedelic properties. It is found in a wide variety of plant species, and a single psychoactive toad species, the Colorado River toad. This drug,... Rebeccamycin Rebeccamycin is a weak topoisomerase I inhibitor isolated from Nocardia sp. CEP-9722 CEP-9722 is under investigation in clinical trial NCT01345357 (Study of CEP-9722 in Combination With Gemcitabine and Cisplatin in Patients With Advanced Solid Tumors or Mantle Cell Lymphoma). Flortaucipir Flortaucipir is under investigation in clinical trial NCT03507257 (Longitudinal Early-onset Alzheimer's Disease Study Protocol). 18-methoxycoronaridine 18-methoxycoronaridine is under investigation in clinical trial NCT03084952 (Phase 2 Trial to Evaluate 18-Methoxycoronaridine Efficacy, Safety and Tolerability in Cutaneous Leishmaniasis Patients). Posiphen Posiphen is under investigation in clinical trial NCT02925650 (Safety, Tolerability, PK and PD of Posiphen® in Subjects With Early Alzheimer's Disease). Tozuleristide Tozuleristide is under investigation in clinical trial NCT02464332 (Safety Study of BLZ-100 in Adult Subjects With Sarcoma Undergoing Surgery). Raubasine Not Annotated Strychnine Not Annotated Carbazochrome sulfonic acid A hemostatic agent indicated to treat bleeding in capillary fragility. Cytochalasin B Not Annotated Indigo Not Annotated TIK-301 Not Annotated Ellipticine Ellipticine is a potent antineoplastic agent. Go-6976 An inhibitor of calcium-dependent isoforms of protein kinase C.[A253002,A253007] ZK-93423 ZK-93423 is a beta-carboline with muscle relaxant activity with agonistic properties at the benzodiazepine receptor. - Drugs & Drug Targets