- Accession Number
Compounds with a core of fused benzo-pyran rings.
Drug Drug Description Vitamin E An antioxidant vitamin used in many skin creams and multivitamin preparations. Troglitazone For the treatment of Type II diabetes mellitus. It is used alone or in combination with a sulfonylurea, metformin, or insulin as an adjunct to diet and exercise. Dicoumarol For decreasing blood clotting. Often used along with heparin for treatment of deep vein thrombosis. Methoxsalen A furocoumarin used to treat psoriasis and vitiligo. Phenprocoumon Used for the prevention and treatment of thromboembolic disease including venous thrombosis, thromboembolism, and pulmonary embolism as well as for the prevention of ischemic stroke in patients with atrial fibrillation... Cromoglicic acid A medication used to treat asthma, allergic reactions of the eyes and nose, as well as other mast cell reactions. Novobiocin For the treatment of infections due to staphylococci and other susceptible organisms Hesperetin For lowering cholesterol and, possibly, otherwise favorably affecting lipids. In vitro research also suggests the possibility that hesperetin might have some anticancer effects and that it might have some anti-aromatase... Flavoxate A muscarinic antagonist and spasmolytic used for the symptomatic relief of conditions associated with lack of muscle control in the bladder, such as dysuria, urgency, and nocturia. Pranlukast Used as an adjunct to the standard therapy of inhaled steroids with inhaled long- and/or short-acting beta-agonists. Acenocoumarol An anticoagulant drug used in the prevention of thromboembolic diseases in infarction and transient ischemic attacks, as well as management of deep vein thrombosis and myocardial infarction. Genistein Currently Genistein is being studied in clinical trials as a treatment for prostate cancer. Rutin A flavonol glycoside found in many plants, including buckwheat; tobacco; forsythia; hydrangea; viola, etc. It has been used therapeutically to decrease capillary fragility. Daidzin Not Available Myricetin Not Available LY-294002 Specific inhibitor of phosphatidylinositol 3-kinase. 4-hydroxycoumarin Not Available Naringenin Not Available Alvocidib Investigated for use/treatment in esophageal cancer, leukemia (lymphoid), lung cancer, liver cancer, and lymphoma (unspecified). Epigallocatechin Not Available Clorobiocin Clorobiocin is an aminocoumarin antibiotic, similar to novobiocin and coumermycin A1. Quercetin Quercetin is a flavonol widely distributed in plants. It is an antioxidant, like many other phenolic heterocyclic compounds. Glycosylated forms include RUTIN and quercetrin. 4'-Hydroxyflavanone Not Available 3,4-Dichloroisocoumarin Not Available Trioxsalen A psoralen derivative that has been used in combination with UV light to treat vitiligo, but has been discontinued by its manufacturer. Coumarin Not Available Hesperidin A bioflavonoid found in a variety of nutritional supplements that is touted to have various beneficial effects on blood vessel disorders and various other conditions. Nebivolol A beta blocking agent used to treat hypertension and aid in the management of heart failure. Calanolide A For use in combination treatment of HIV infection (AIDS). Idronoxil Intended for the treatment of various forms of cancer. Crofelemer An antidiarrheal agent used for the symptomatic relief of drug-induced non-infectious diarrhea in adult patients with HIV/AIDS receiving antiretroviral therapy. Elafibranor Investigated for use/treatment in atherosclerosis and diabetes mellitus type 2. Sofalcone Investigated for use/treatment in gastroenteritis and ulcers. SF1126 For the treatment of various forms of cancer. Triphendiol Investigated for use/treatment in cancer/tumors (unspecified). beta-Naphthoflavone β-Naphthoflavone, also known as 5,6-benzoflavone, is a potent agonist of the aryl hydrocarbon receptor and induces cytochromes P450 (CYPs) and uridine 5'-diphospho-glucuronosyltransferases (UGTs). It may be a chemopreventive agent. Hymecromone Not Available Apigenin Not Available Flavone Not Available Ethyl biscoumacetate Ethyl biscoumacetate is a courmarin that is used as an anticoagulant. It has actions similar to those of Warfarin. (From Martindale, The Extra Pharmacopoeia, 30th ed, p226) Ellagic acid Ellagic acid is being investigated for use in follicular lymphoma, brain injury in intrauterine growth restricted babies, obese adolescents, and solar lentigines. Diosmin Diosmin is a semisynthetic drug indicated for the treatment of venous disease. Diosmin is a flavone that can be found in the plant Teucrium gnaphalodes. Diosmin is available as a... Tocopherol Tocopherol can be used as a dietary supplement for patients with a deficit of vitamin E; this is mainly prescribed in the alpha form. Vitamin E deficiency is rare, and... Diosmetin Diosmetin is an O-methylated flavone and the aglycone part of the flavonoid glycosides diosmin that occurs naturally in citrus fruits . Pharmacologically, diosmetin is reported to exhibit anticancer, antimicrobial, antioxidant,... Coumaphos This drug is a fat-soluble phosphorothioate agent that kills both insects and mites. It is non-volatile in nature and is well known by a variety of names as such a... Haloxon Not Annotated Rotenone Rotenone is an isoflavone compound that naturally occurs in the jicama vine plant as well as many Fabaceae plants. It has broad spectrum insecticide and pesticide activity and is also... Tocofersolan A derivative of alpha tocopherol used to treat vitamin E deficiencies. Equol Equol has been used in trials studying the treatment of Breast Cancer. Epicatechin Epicatechin has been used in trials studying the treatment of Pre-diabetes. Icariin Icariin has been investigated for the basic science of the Pharmacokinetic Profile of Icariin in Humans. Recoflavone Recoflavone has been used in trials studying the treatment of Acute Gastritis, Dry Eye Syndrome, and Chronic Gastritis. Epigallocatechin gallate Epigallocatechin gallate has been investigated for the treatment of Hypertension and Diabetic Nephropathy. Bergapten Bergapten is under investigation in clinical trial NCT00533195 (Comparison of UVA1 Phototherapy Versus Photochemotherapy for Patients With Severe Generalized Atopic Dermatitis). Iguratimod Iguratimod is under investigation in Rheumatoid Arthritis. Puerarin Puerarin has been investigated for the treatment of Alcohol Abuse. Tocotrienol Tocotrienol has been investigated for the treatment of Cholesterol Lowering. Isoquercetin Isoquercetin has been used in trials studying the treatment of Kidney Cancer, Renal cell carcinoma, Advanced Renal Cell Carcinoma, Thromboembolism of Vein in Pancreatic Cancer, and Thromboembolism of Vein VTE... Icaritin Icaritin has been used in trials studying the treatment of Solid Tumors, Metastatic Breast Cancer, and Hepatocellular Carcinoma (HCC). Tecarfarin Tecarfarin has been used in trials studying the prevention of Thrombosis and Thromboembolism. CP-195543 CP-195,543 has been used in trials studying the treatment of Arthritis, Rheumatoid. ME-344 ME-344 has been used in trials studying the treatment of Solid Tumors. Chromanol Chromanol has been used in trials studying the treatment of Prostate Cancer. Troxerutin Troxerutin has been used in trials studying the treatment of Chronic Venous Insufficiency. Esculin As medication, esculin is sometimes used as a vasoprotective agent. Esculin is also used in a microbiology laboratory to aid in the identification of bacterial species (especially Enterococci and Listeria),... 4-methylumbelliferyl beta-D-glucoside Not Annotated Daidzein Not Annotated Carbocromen Carbocromen was marketed for use in Germany as a vasodilator, however, it has been discontinued due to the risk of arrhythmia development . Efloxate Not Annotated Visnadine Not Annotated Cloricromen Not Annotated Tioclomarol Not Annotated Dimefline Not Annotated Hidrosmin Not Annotated Ipriflavone Not Annotated Coumermycin A1 Not Annotated alpha-Tocopherol succinate A form of vitamin E used to treat and prevent vitamin deficiencies. alpha-Tocopherol acetate A form of vitamin E used to treat and prevent vitamin deficiencies. Hispidulin Hispidulin (4',5,7-trihydroxy-6-methoxyflavone) is a potent benzodiazepine (BZD) receptor ligand with positive allosteric properties . Cianidanol An antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms. Tocopherylquinone Not Annotated Dihydroxymethoxychalcone Cardamonin (also known as Dihydroxymethoxychalcone), as shown by the increasing number of publications, has received growing attention from the scientific community due to the expectations toward its benefits to human... Citrus bioflavonoids Not Annotated Taxifolin Not Available Isoliquiritigenin Isoliquiritigenin is a precursor to several flavonones in many plants. Fisetin Not Available Silibinin Currently being tested as a treatment of severe intoxications with hepatotoxic substances, such as death cap (Amanita phalloides) poisoning. AZD-8186 AZD-8186 is under investigation in clinical trial NCT03218826 (PI3Kbeta Inhibitor AZD8186 and Docetaxel in Treating Patients Advanced Solid Tumors With PTEN or PIK3CB Mutations That Are Metastatic or Cannot Be... RO-5126766 free base RO-5126766 free base is under investigation in clinical trial NCT03875820 (Phase I Trial of VS-6063 and RO5126766.). Biochanin A Biochanin A is under investigation in clinical trial NCT02174666 (Isoflavone Treatment for Postmenopausal Osteopenia.). Formononetin Formononetin is under investigation in clinical trial NCT02174666 (Isoflavone Treatment for Postmenopausal Osteopenia.). Xanthohumol Xanthohumol is under investigation in clinical trial NCT01367431 (Xanthohumol and Metabolic Syndrome). gamma-Tocopherol gamma-Tocopherol is under investigation in clinical trial NCT00836368 (In Vitro Basophil Responsiveness to Allergen Challenge After Gamma-tocopherol Supplementation in Allergic Asthmatics). Urolithin A Urolithin A is a metabolite of ellagic acid. It has been demonstrated to stimulate mitophagy and improve muscle health in old animals and in preclinical models of aging. Resveratrol Being investigated for the treatment of Herpes labialis infections (cold sores). Tricetin Not Available 4-methyl-umbelliferyl-N-acetyl-chitobiose Not Available Chrysin Not Annotated Luteolin Not Annotated Phloretin Phloretin is a natural dihydrochalcone found in apples and many other fruits. Coumarin 120 Not Available Bisphenol A Not Available alpha-Naphthoflavone Not Available Sakuranetin Not Available Dihydromyricetin Dihydromyricetin is under investigation in clinical trial NCT03606694 (Effect of Dihydromirycetin on Glycemic Control, Insulin Sensitivity and Insulin Secretion in Type 2 Diabetes Mellitus). Maritime pine extract Not Annotated Tocopheryl nicotinate Not Annotated Hesperidin methylchalcone Not Annotated Baicalein Baicalein is under investigation in clinical trial NCT03830684 (A Randomized, Double-blind, Placebo-controlled, Multicenter and Phase ⅡA Clinical Trial for the Effectiveness and Safety of Baicalein Tablets in the Treatment of... Epigallo Catechin Gallate Epigallo Catechin Gallate is under investigation in clinical trial NCT00799890 (Sunphenon in Progressive Forms of Multiple Sclerosis). Isoquercitrin Isoquercitrin is under investigation in clinical trial NCT04622865 (Masitinib Combined With Isoquercetin and Best Supportive Care in Hospitalized Patients With Moderate and Severe COVID-19).
- Drugs & Drug Targets