| Vitamin E | An antioxidant vitamin used in many skin creams and multivitamin preparations. |
| Troglitazone | For the treatment of Type II diabetes mellitus. It is used alone or in combination with a sulfonylurea, metformin, or insulin as an adjunct to diet and exercise. |
| Dicoumarol | For decreasing blood clotting. Often used along with heparin for treatment of deep vein thrombosis. |
| Mupirocin | An antibacterial ointment used to treat impetigo and secondary skin infections caused by Staphylococcus aureus and Streptococcus pyogenes. |
| Methoxsalen | A furocoumarin used to treat psoriasis and vitiligo. |
| Zanamivir | A neuraminidase inhibitor used to treat influenza A and B. |
| Warfarin | A vitamin K antagonist used to treat venous thromboembolism, pulmonary embolism, thromboembolism with atrial fibrillation, thromboembolism with cardiac valve replacement, and thromboembolic events post myocardial infarction. |
| Tipranavir | A protease inhibitor used to treat HIV-1 resistant to more than 1 protease inhibitor. |
| Phenprocoumon | Used for the prevention and treatment of thromboembolic disease including venous thrombosis, thromboembolism, and pulmonary embolism as well as for the prevention of ischemic stroke in patients with atrial fibrillation... |
| Cromoglicic acid | A medication used to treat asthma, allergic reactions of the eyes and nose, as well as other mast cell reactions. |
| Novobiocin | For the treatment of infections due to staphylococci and other susceptible organisms |
| Hesperetin | For lowering cholesterol and, possibly, otherwise favorably affecting lipids. In vitro research also suggests the possibility that hesperetin might have some anticancer effects and that it might have some anti-aromatase... |
| Flavoxate | A muscarinic antagonist and spasmolytic used for the symptomatic relief of conditions associated with lack of muscle control in the bladder, such as dysuria, urgency, and nocturia. |
| Pranlukast | Used as an adjunct to the standard therapy of inhaled steroids with inhaled long- and/or short-acting beta-agonists. |
| Acenocoumarol | An anticoagulant drug used in the prevention of thromboembolic diseases in infarction and transient ischemic attacks, as well as management of deep vein thrombosis and myocardial infarction. |
| Genistein | Currently Genistein is being studied in clinical trials as a treatment for prostate cancer. |
| Rutin | A flavonol glycoside found in many plants, including buckwheat; tobacco; forsythia; hydrangea; viola, etc. It has been used therapeutically to decrease capillary fragility. |
| Daidzin | Not Available |
| Myricetin | Not Available |
| LY-294002 | Specific inhibitor of phosphatidylinositol 3-kinase. |
| 4-hydroxycoumarin | Not Available |
| Naringenin | Not Available |
| Alvocidib | Investigated for use/treatment in esophageal cancer, leukemia (lymphoid), lung cancer, liver cancer, and lymphoma (unspecified). |
| Epigallocatechin | Not Available |
| Clorobiocin | Clorobiocin is an aminocoumarin antibiotic, similar to novobiocin and coumermycin A1. |
| Quercetin | Quercetin is a flavonol widely distributed in plants. It is an antioxidant, like many other phenolic heterocyclic compounds. Glycosylated forms include RUTIN and quercetrin. |
| 4'-Hydroxyflavanone | Not Available |
| 3,4-Dichloroisocoumarin | Not Available |
| Trioxsalen | A psoralen derivative that has been used in combination with UV light to treat vitiligo, but has been discontinued by its manufacturer. |
| Coumarin | Not Available |
| Hesperidin | A bioflavonoid found in a variety of nutritional supplements that is touted to have various beneficial effects on blood vessel disorders and various other conditions. |
| Nebivolol | A beta blocking agent used to treat hypertension and aid in the management of heart failure. |
| Calanolide A | For use in combination treatment of HIV infection (AIDS). |
| Idronoxil | Intended for the treatment of various forms of cancer. |
| Crofelemer | An antidiarrheal agent used for the symptomatic relief of drug-induced non-infectious diarrhea in adult patients with HIV/AIDS receiving antiretroviral therapy. |
| ADL5859 | Investigated for use/treatment in pain (acute or chronic). |
| Elafibranor | Investigated for use/treatment in atherosclerosis and diabetes mellitus type 2. |
| EPC2407 | Investigated for use/treatment in cancer/tumors (unspecified). |
| Sofalcone | Investigated for use/treatment in gastroenteritis and ulcers. |
| SF1126 | For the treatment of various forms of cancer. |
| Gallium maltolate | Investigated for use/treatment in bladder cancer, lymphoma (unspecified), multiple myeloma, paget's disease, and prostate cancer. |
| Custirsen | Investigated for use/treatment in brain cancer and breast cancer. |
| CHF 4227 | Investigated for use/treatment in osteoporosis. |
| Repinotan | Investigated for use/treatment in strokes, cerebral ischemia, and depression. |
| Robalzotan | Investigated for use/treatment in anxiety disorders and depression. |
| Tonabersat | Investigated for use/treatment in migraine and cluster headaches. |
| Triphendiol | Investigated for use/treatment in cancer/tumors (unspecified). |
| beta-Naphthoflavone | β-Naphthoflavone, also known as 5,6-benzoflavone, is a potent agonist of the aryl hydrocarbon receptor and induces cytochromes P450 (CYPs) and uridine 5'-diphospho-glucuronosyltransferases (UGTs). It may be a chemopreventive agent. |
| Zaltoprofen | A non-steroidal anti-inflammatory drug approved for use in Japan in 1993. |
| Hymecromone | Not Available |
| Apigenin | Not Available |
| AUROVERTIN B | Not Available |
| Flavone | Not Available |
| Ethyl biscoumacetate | Ethyl biscoumacetate is a courmarin that is used as an anticoagulant. It has actions similar to those of Warfarin. (From Martindale, The Extra Pharmacopoeia, 30th ed, p226) |
| Ellagic acid | Ellagic acid is being investigated for use in follicular lymphoma, brain injury in intrauterine growth restricted babies, obese adolescents, and solar lentigines. |
| Diosmin | Diosmin is a semisynthetic drug indicated for the treatment of venous disease. Diosmin is a flavone that can be found in the plant Teucrium gnaphalodes. Diosmin is available as a... |
| Lortalamine | Lortalamine (LM-1404) is a selective norepinephrine reuptake inhibitor developed in the 1980s. This drug never made it past clinical trials, likely due to ocular toxicity in animals, but has been... |
| Tocopherol | Tocopherol can be used as a dietary supplement for patients with a deficit of vitamin E; this is mainly prescribed in the alpha form. Vitamin E deficiency is rare, and... |
| Diosmetin | Diosmetin is an O-methylated flavone and the aglycone part of the flavonoid glycosides diosmin that occurs naturally in citrus fruits . Pharmacologically, diosmetin is reported to exhibit anticancer, antimicrobial, antioxidant,... |
| Coumaphos | This drug is a fat-soluble phosphorothioate agent that kills both insects and mites. It is non-volatile in nature and is well known by a variety of names as such a... |
| Haloxon | Not Annotated |
| Rotenone | Rotenone is an isoflavone compound that naturally occurs in the jicama vine plant as well as many Fabaceae plants. It has broad spectrum insecticide and pesticide activity and is also... |
| Semduramicin | Not Annotated |
| Tocofersolan | A derivative of alpha tocopherol used to treat vitamin E deficiencies. |
| Equol | Equol has been used in trials studying the treatment of Breast Cancer. |
| Filibuvir | Filibuvir has been used in trials studying the treatment of Hepatitis, Hepatitis C, and Chronic Hepatitis C. |
| Laninamivir octanoate | Laninamivir octanoate has been used in trials studying the treatment of Asthma. |
| Epicatechin | Epicatechin has been used in trials studying the treatment of Pre-diabetes. |
| Icariin | Icariin has been investigated for the basic science of the Pharmacokinetic Profile of Icariin in Humans. |
| Recoflavone | Recoflavone has been used in trials studying the treatment of Acute Gastritis, Dry Eye Syndrome, and Chronic Gastritis. |
| Epigallocatechin gallate | Epigallocatechin gallate has been investigated for the treatment of Hypertension and Diabetic Nephropathy. |
| Bergapten | Bergapten is under investigation in clinical trial NCT00533195 (Comparison of UVA1 Phototherapy Versus Photochemotherapy for Patients With Severe Generalized Atopic Dermatitis). |
| Iguratimod | Iguratimod is under investigation in Rheumatoid Arthritis. |
| CRS-3123 | CRS3123 has been used in trials studying the treatment of Clostridial Infection and Clostridium Difficile Colitis. |
| Puerarin | Puerarin has been investigated for the treatment of Alcohol Abuse. |
| Tocotrienol | Tocotrienol has been investigated for the treatment of Cholesterol Lowering. |
| AFN-1252 | AFN-1252 has been used in trials studying the treatment of Cellulitis, Burn Infection, Wound Infection, Cutaneous Abscess, and Skin and Subcutaneous Tissue Bacterial Infections. |
| Isoquercetin | Isoquercetin has been used in trials studying the treatment of Kidney Cancer, Renal cell carcinoma, Advanced Renal Cell Carcinoma, Thromboembolism of Vein in Pancreatic Cancer, and Thromboembolism of Vein VTE... |
| Icaritin | Icaritin has been used in trials studying the treatment of Solid Tumors, Metastatic Breast Cancer, and Hepatocellular Carcinoma (HCC). |
| Laninamivir | Laninamivir has been used in trials studying the treatment of Influenza. |
| Palomid 529 | Palomid 529 has been used in trials studying the treatment of Age-Related Macular Degeneration. |
| Tecarfarin | Tecarfarin has been used in trials studying the prevention of Thrombosis and Thromboembolism. |
| Crolibulin | Crolibulin has been used in trials studying the treatment of Solid Tumor and Anaplastic Thyroid Cancer. |
| CP-195543 | CP-195,543 has been used in trials studying the treatment of Arthritis, Rheumatoid. |
| ME-344 | ME-344 has been used in trials studying the treatment of Solid Tumors. |
| Chromanol | Chromanol has been used in trials studying the treatment of Prostate Cancer. |
| Troxerutin | Troxerutin has been used in trials studying the treatment of Chronic Venous Insufficiency. |
| PM-060184 | PM060184 has been used in trials studying Solid Tumors. |
| Esculin | As medication, esculin is sometimes used as a vasoprotective agent.
Esculin is also used in a microbiology laboratory to aid in the identification of bacterial species (especially Enterococci and Listeria),... |
| 4-methylumbelliferyl beta-D-glucoside | Not Annotated |
| Daidzein | Not Annotated |
| Carbocromen | Carbocromen was marketed for use in Germany as a vasodilator, however, it has been discontinued due to the risk of arrhythmia development . |
| Ormeloxifene | Not Annotated |
| Efloxate | Not Annotated |
| Visnadine | Not Annotated |
| Cloricromen | Not Annotated |
| Tioclomarol | Not Annotated |
| Dimefline | Not Annotated |
| Hidrosmin | Not Annotated |
| Pranoprofen | Not Annotated |
| Ipriflavone | Not Annotated |
| Coumermycin A1 | Not Annotated |
| alpha-Tocopherol succinate | A form of vitamin E used to treat and prevent vitamin deficiencies. |
| alpha-Tocopherol acetate | A form of vitamin E used to treat and prevent vitamin deficiencies. |
| Hispidulin | Hispidulin (4',5,7-trihydroxy-6-methoxyflavone) is a potent benzodiazepine (BZD) receptor ligand with positive allosteric properties . |
| Englitazone | Englitazone is a hypoglycemic agent. |
| Nigericin | A polyether antibiotic which affects ion transport and ATPase activity in mitochondria. It is produced by Streptomyces hygroscopicus. (From Merck Index, 11th ed) |
| HM-30181 | Not Annotated |
| Cianidanol | An antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms. |
| Tocopherylquinone | Not Annotated |
| Dihydroxymethoxychalcone | Cardamonin (also known as Dihydroxymethoxychalcone), as shown by the increasing number of publications, has received growing attention from the scientific community due to the expectations toward its benefits to human... |
| Citrus bioflavonoids | Not Annotated |
| Kojic acid | Not Available |
| Taxifolin | Not Available |
| Isoliquiritigenin | Isoliquiritigenin is a precursor to several flavonones in many plants. |
| Erteberel | Erteberel is an estrogen receptor beta agonist that has been used in trials studying the treatment of Benign Prostatic Hyperplasia. |
| Fisetin | Not Available |
| Silibinin | Currently being tested as a treatment of severe intoxications with hepatotoxic substances, such as death cap (Amanita phalloides) poisoning. |
| AZD-8186 | AZD-8186 is under investigation in clinical trial NCT03218826 (PI3Kbeta Inhibitor AZD8186 and Docetaxel in Treating Patients Advanced Solid Tumors With PTEN or PIK3CB Mutations That Are Metastatic or Cannot Be... |
| RO-5126766 free base | RO-5126766 free base is under investigation in clinical trial NCT03875820 (Phase I Trial of VS-6063 and RO5126766.). |
| Etamicastat | Etamicastat is under investigation in clinical trial NCT02840565 (Tolerability, Pharmacokinetics and Pharmacodynamics of Six Multiple Rising Dose Regimens of BIA 5-453). |
| Biochanin A | Biochanin A is under investigation in clinical trial NCT02174666 (Isoflavone Treatment for Postmenopausal Osteopenia.). |
| Formononetin | Formononetin is under investigation in clinical trial NCT02174666 (Isoflavone Treatment for Postmenopausal Osteopenia.). |
| Xanthohumol | Xanthohumol is under investigation in clinical trial NCT01367431 (Xanthohumol and Metabolic Syndrome). |
| gamma-Tocopherol | gamma-Tocopherol is under investigation in clinical trial NCT00836368 (In Vitro Basophil Responsiveness to Allergen Challenge After Gamma-tocopherol Supplementation in Allergic Asthmatics). |
| Urolithin A | Urolithin A is a metabolite of ellagic acid. It has been demonstrated to stimulate mitophagy and improve muscle health in old animals and in preclinical models of aging. |
| Resveratrol | Being investigated for the treatment of Herpes labialis infections (cold sores). |
| Tricetin | Not Available |
| Zamicastat | Zamicastat has been used in trials studying the treatment of Hypertension and Chronic Heart Failure. |
| Voruciclib | Voruciclib is under investigation in clinical trial NCT03547115 (A Phase 1 Study of Voruciclib in Subjects With B-Cell Malignancies or AML). |
| 4-methyl-umbelliferyl-N-acetyl-chitobiose | Not Available |
| Chrysin | Not Annotated |
| Luteolin | Not Annotated |
| Patulin | Not Annotated |
| Ferric maltol | A complexed iron supplement used to treat iron deficiency in adults. |
| Phloretin | Phloretin is a natural dihydrochalcone found in apples and many other fruits. |
| Coumarin 120 | Not Available |
| Bisphenol A | Not Available |
| alpha-Naphthoflavone | Not Available |
| Sakuranetin | Not Available |
| Dihydromyricetin | Dihydromyricetin is under investigation in clinical trial NCT03606694 (Effect of Dihydromirycetin on Glycemic Control, Insulin Sensitivity and Insulin Secretion in Type 2 Diabetes Mellitus). |
| Maritime pine extract | Not Annotated |