Amino Acids, Essential

Name
Amino Acids, Essential
Accession Number
DBCAT000242
Description

The nine amino acids that are not synthesized by the human body in amounts sufficient to carry out physiological functions. They are obtained from dietary foodstuffs.

Drugs
DrugDrug Description
HistidineAn amino acid commonly found as a component of total parenteral nutrition.
PhenylalanineAn amino acid commonly found as a component of total parenteral nutrition.
LysineAn amino acid commonly found as a component of total parenteral nutrition.
MethionineAn amino acid commonly found as a component in total parenteral nutrition.
LeucineAn amino acid commonly found as a component of total parenteral nutrition.
TryptophanAn amino acid commonly found as a component of total parenteral nutrition.
ThreonineAn amino acid commonly found as a component of total parenteral nutrition.
ValineAn amino acid commonly found as a component of total parenteral nutrition.
IsoleucineAn amino acid commonly found as a component of total parenteral nutrition.
ArgatrobanA synthetic direct thrombin inhibitor used for the prevention and treatment of thrombosis related to heparin use.
RupintrivirInvestigated for use/treatment in viral infection.
DaclatasvirA direct-acting antiviral agent used to treat specific hepatitis C virus (HCV) infections in combination with other antiviral agents.
SacubitrilA neprilysin inhibitor used in combination with valsartan as an adjunct to reduce the risk of cardiovascular death and hospitalization for heart failure in patients with chronic heart failure (NYHA Class II-IV) and reduced ejection fraction.
OmbitasvirA direct acting antiviral agent used in combination with other antiviral agents for the treatment of Hepatitis C Virus (HCV) infections.
FaldaprevirFaldaprevir has been investigated for the treatment of Chronic Hepatitis C.
VaniprevirVaniprevir has been used in trials studying the treatment and diagnostic of Hepatitis C, Chronic Hepatitis C, Hepatitis C, Chronic, Chronic Hepatitis C Infection, and Chronic Genotype 1 Hepatitis C...
VoxilaprevirA nonstructural protein 3 and 4a protease inhibitor used to treat Hepatitis C infections.
GlecaprevirA Hepatitis C NS3/4A protease inhibitor used to treat Hepatitis C.
NarlaprevirNot Annotated
Piflufolastat F 18A radiopharmaceutical diagnostic agent used with PET to image PSMA-positive lesions for the diagnosis of metastatic or recurrent prostate cancer.
SomapacitanA human growth hormone analog subcutaneous injection indicated for adults with growth hormone deficiency.
GC-376 free acidGC-376 is a 3C-like protease (3CLpro or Mpro) inhibitor that stops the cleavage and activation of functional viral proteins required for replication and transcription in host cells . The compound...
Carotegrast methylCarotegrast methyl is under investigation in clinical trial NCT03531892 (A Study to Evaluate the Safety and Efficacy of AJM300 in Participants With Active Ulcerative Colitis).
PF-07304814PF-07304814 is a small molecule prodrug that targets the 3CLpro protease (Mpro), which is used by viruses like SARS-CoV-2 to assemble and multiply . Once administered through intravenous infusion, the...
NirmatrelvirAn oral protease inhibitor with emergency use authorization for the treatment of mild-to-moderate COVID-19.
L-AcetylleucineNot Annotated
Drugs & Drug Targets
DrugTargetType
HistidineHistidine decarboxylasetarget
HistidineHistidine--tRNA ligase, cytoplasmictarget
HistidineSodium-coupled neutral amino acid transporter 3target
HistidineHistidine ammonia-lyasetarget
HistidineMonocarboxylate transporter 10transporter
PhenylalanineTyrosine aminotransferasetarget
PhenylalanineLarge neutral amino acids transporter small subunit 2target
PhenylalaninePhenylalanine--tRNA ligase alpha subunittarget
PhenylalaninePhenylalanine-4-hydroxylasetarget
PhenylalaninePhenylalanine--tRNA ligase, mitochondrialtarget
PhenylalaninePhenylalanine--tRNA ligase beta subunittarget
PhenylalanineTyrosine 3-monooxygenasetarget
PhenylalanineMonocarboxylate transporter 10transporter
LysineHigh affinity cationic amino acid transporter 1target
LysineCationic amino acid transporter 4target
LysineCationic amino acid transporter 3target
LysineLow affinity cationic amino acid transporter 2target
LysineLysine--tRNA ligasetarget
LysineMonocarboxylate transporter 10transporter
LysineSolute carrier family 22 member 4transporter
MethionineMethionine synthase reductasetarget
MethionineMethionine synthasetarget
MethionineMethionine aminopeptidase 2target
MethionineBetaine--homocysteine S-methyltransferase 1target
MethionineS-methylmethionine--homocysteine S-methyltransferase BHMT2target
MethionineGlutamine synthetaseenzyme
MethionineMethylenetetrahydrofolate reductaseenzyme
MethionineMonocarboxylate transporter 10transporter
MethionineS-adenosylmethionine synthase isoform type-2enzyme
MethionineMethionine-R-sulfoxide reductase B2, mitochondrialenzyme
MethionineS-adenosylmethionine synthase isoform type-1enzyme
MethionineMethionine-R-sulfoxide reductase B1enzyme
MethionineMitochondrial peptide methionine sulfoxide reductaseenzyme
MethionineMethionine--tRNA ligase, cytoplasmicenzyme
MethionineMethionine--tRNA ligase, mitochondrialenzyme
MethionineMethionine adenosyltransferase 2 subunit betaenzyme
MethionineS-methylmethionine--homocysteine S-methyltransferase BHMT2enzyme
LeucineProbable leucine--tRNA ligase, mitochondrialtarget
LeucineLeucine carboxyl methyltransferase 2target
LeucineLeucine carboxyl methyltransferase 1target
LeucineLeucine--tRNA ligase, cytoplasmictarget
LeucineBranched-chain-amino-acid aminotransferase, mitochondrialtarget
LeucineBranched-chain-amino-acid aminotransferase, cytosolictarget
LeucineMonocarboxylate transporter 10transporter
LeucineMonocarboxylate transporter 8transporter
TryptophanTryptophan--tRNA ligase, cytoplasmictarget
TryptophanTryptophan--tRNA ligasetarget
TryptophanTryptophan--tRNA ligase, mitochondrialtarget
TryptophanTryptophan 2,3-dioxygenaseenzyme
TryptophanAromatic-L-amino-acid decarboxylaseenzyme
TryptophanMonocarboxylate transporter 8transporter
TryptophanMonocarboxylate transporter 10transporter
TryptophanTryptophan--tRNA ligaseenzyme
TryptophanTryptophan--tRNA ligase, mitochondrialenzyme
TryptophanTryptophan 5-hydroxylase 1enzyme
TryptophanTryptophan 5-hydroxylase 2enzyme
TryptophanTryptophan--tRNA ligase, cytoplasmicenzyme
TryptophanIndoleamine 2,3-dioxygenase 1enzyme
ThreonineThreonine--tRNA ligase, cytoplasmictarget
ThreonineThreonine--tRNA ligase, mitochondrialtarget
ThreonineMonocarboxylate transporter 10transporter
ThreonineBeta-lactamase Toho-1target
ValinePropionyl-CoA carboxylase beta chain, mitochondrialtarget
ValineBranched-chain-amino-acid aminotransferase, cytosolictarget
ValineValine--tRNA ligasetarget
ValineMonocarboxylate transporter 10transporter
ValineValine--tRNA ligaseenzyme
ValinePropionyl-CoA carboxylase beta chain, mitochondrialenzyme
ValineBranched-chain-amino-acid aminotransferase, cytosolicenzyme
IsoleucineShort/branched chain specific acyl-CoA dehydrogenase, mitochondrialtarget
IsoleucineBranched-chain-amino-acid aminotransferase, cytosolictarget
IsoleucineBranched-chain-amino-acid aminotransferase, mitochondrialtarget
IsoleucineIsoleucine--tRNA ligase, cytoplasmictarget
IsoleucineIsoleucine--tRNA ligase, mitochondrialtarget
IsoleucineMonocarboxylate transporter 10transporter
ArgatrobanProthrombintarget
ArgatrobanCytochrome P450 3A4enzyme
ArgatrobanCytochrome P450 3A5enzyme
ArgatrobanSerum albumincarrier
Argatrobanalpha1-acid glycoproteincarrier
RupintrivirGenome polyproteintarget
DaclatasvirNonstructural protein 5Atarget
DaclatasvirCytochrome P450 3A5enzyme
DaclatasvirCytochrome P450 3A4enzyme
DaclatasvirCytochrome P450 3A43enzyme
DaclatasvirCytochrome P450 3A7enzyme
DaclatasvirP-glycoprotein 1transporter
DaclatasvirSolute carrier organic anion transporter family member 1B1transporter
DaclatasvirSolute carrier organic anion transporter family member 1B3transporter
DaclatasvirATP-binding cassette sub-family G member 2transporter
SacubitrilNeprilysintarget
SacubitrilSolute carrier organic anion transporter family member 1B1transporter
SacubitrilSolute carrier organic anion transporter family member 1B3transporter
OmbitasvirNonstructural protein 5Atarget
OmbitasvirCytochrome P450 2C8enzyme
OmbitasvirP-glycoprotein 1transporter
OmbitasvirATP-binding cassette sub-family G member 2transporter
OmbitasvirUDP-glucuronosyltransferase 1-1enzyme
VoxilaprevirCytochrome P450 3A4enzyme
VoxilaprevirCytochrome P450 1A2enzyme
VoxilaprevirCytochrome P450 2C8enzyme
VoxilaprevirNS3/4A proteintarget
VoxilaprevirP-glycoprotein 1transporter
VoxilaprevirATP-binding cassette sub-family G member 2transporter
VoxilaprevirSolute carrier organic anion transporter family member 1B1transporter
VoxilaprevirSolute carrier organic anion transporter family member 1B3transporter
GlecaprevirCytochrome P450 3A Subfamilyenzyme
GlecaprevirUDP-glucuronosyltransferase 1-1enzyme
GlecaprevirP-glycoprotein 1transporter
GlecaprevirATP-binding cassette sub-family G member 2transporter
GlecaprevirSolute carrier organic anion transporter family member 1B1transporter
GlecaprevirSolute carrier organic anion transporter family member 1B3transporter
GlecaprevirNS3 proteasetarget
GlecaprevirCytochrome P450 3A4enzyme
Piflufolastat F 18Glutamate carboxypeptidase 2target
SomapacitanCorticosteroid 11-beta-dehydrogenase isozyme 1enzyme
SomapacitanCytochrome P450 2C12, female-specificenzyme
SomapacitanCytochrome P450 1A2enzyme
SomapacitanCytochrome P450 2C19enzyme
SomapacitanSerum albumincarrier
SomapacitanGrowth hormone receptortarget
GC-376 free acidReplicase polyprotein 1abtarget
GC-376 free acidReplicase polyprotein 1atarget
GC-376 free acidReplicase polyprotein 1abtarget
GC-376 free acidReplicase polyprotein 1atarget
GC-376 free acidReplicase polyprotein 1abtarget
PF-07304814Replicase polyprotein 1abtarget
NirmatrelvirReplicase polyprotein 1abtarget
NirmatrelvirCytochrome P450 3A4enzyme
NirmatrelvirP-glycoprotein 1transporter