- Accession Number
Saturated derivatives of the steroid pregnane. The 5-beta series includes PROGESTERONE and related hormones; the 5-alpha series includes forms generally excreted in the urine.
Drug Drug Description Diflorasone A topical corticosteroid used to treat the symptoms of various inflammatory skin conditions that cause erythema, pruritus, and discomfort. Alclometasone A topical corticosteroid used to relieve the symptoms of corticosteroid-responsive dermatoses. Medrysone A topical glucocorticoid applied ophthalmically for the treatment of various ocular inflammatory or allergic conditions. Amcinonide A topical corticosteroid used in the treatment of inflammation and pruritus due to a variety of dermatoses. Beclomethasone dipropionate An inhaled corticosteroid used as maintenance treatment in the prophylaxis of asthma attacks. Progesterone A hormone used for a variety of functions, including contraception, control of abnormal uterine bleeding, maintenance of pregnancy, and prevention of endometrial hyperplasia. Spironolactone An aldosterone receptor antagonist used for the treatment of hypertension, hyperaldosteronism, edema due to various conditions, hirsutism (off-label) and hypokalemia. Desoximetasone A glucocorticoid used to treat inflammatory and pruritic corticosteroid-responsive dermatoses. Fluocinolone acetonide A corticosteroid used to treat skin conditions, eczematous otitis externa, diabetic macular edema, and non-infectious uveitis of the posterior segment of the eye. Ulobetasol A lipocortin corticosteroid used to treat inflammatory and pruritic corticosteroid-responsive dermatoses. Medroxyprogesterone acetate A progestin used as a contraceptive and in the treatment of secondary amenorrhea, abnormal uterine bleeding, pain from endometriosis, endometrial and renal carcinomas, paraphilia in males, and GnRH-dependent precocious puberty. Triamcinolone A glucocorticoid used to treat a wide variety of inflammatory conditions of organ systems and tissues. Prednisone A corticosteroid used to treat inflammation or immune-mediated reactions and to treat endocrine or neoplastic diseases. Hydrocortisone A glucocorticoid used to treat corticosteroid-responsive dermatoses, endocrine disorders, immune conditions, and allergic disorders. Mometasone A corticosteroid with no indications. Flurandrenolide A corticosteroid used to treat corticosteroid-responsive dermatoses. Prednisolone A glucocorticoid used to treat adrenocortical insufficiency, inflammatory conditions, and some cancers. Rimexolone A glucocorticoid used to treat inflammation of the eye. Methylprednisolone A corticosteroid used to treat inflammation or immune reactions across a variety of organ systems, endocrine conditions, and neoplastic diseases. Clobetasol propionate A corticosteroid used to treat corticosteroid-responsive dermatoses and plaque psoriasis. Fluocinonide A high potency corticosteroid commonly used topically for a number of inflammatory skin conditions. Prednicarbate A medium potency topical corticosteroid used to manage pruritus and inflammation associated with responsive skin conditions. Budesonide A corticosteroid used to treat Crohn's disease, asthma, COPD, hay fever and allergies, and ulcerative colitis. Dexamethasone A glucocorticoid available in various modes of administration that is used for the treatment of various inflammatory conditions, including bronchial asthma, as well as endocrine and rheumatic disorders. Cortisone acetate A steroid hormone used for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses and endocrine disorders associated with inadequate production of steroid hormones. Difluprednate A topical corticosteroid used for the symptomatic treatment of inflammation and pain associated with ocular surgery. Fluocortolone A glucocorticoid used topically for localized skin reactions and also orally for systemic use. Difluocortolone A topical corticosteroid used for the symptomatic treatment of inflammatory skin disorders like eczema, seborrheic eczema, lichen planus and psoriasis. Brexanolone Brexanolone is a synthetic neuroactive steroid gamma-aminobutyric acid A (GABA(a)) receptor positive modulator indicated for the treatment of postpartum depression (PPD) in adult women [FDA Label][A176080, A176083, F4063, F4066, F4072]. Eltanolone Eltanolone is under investigation in clinical trial NCT02603926 (Treatment of Fragile-X Associated Tremor/Ataxia Syndrome (FXTAS) With Allopregnanolone). Clascoterone An androgen receptor antagonist used for the topical treatment of acne vulgaris in patients 12 years of age and older. Clobetasone A corticosteroid used to treat dry eyes, eczema, and dermatitis. Prednisolone phosphate A corticosteroid used to treat inflammation, immune reactions, as well as endocrine or neoplastic conditions. Betamethasone phosphate A fast acting ester prodrug of a corticosteroid used to treat inflammatory conditions. Prednisolone acetate A glucocorticoid used to treat a wide variety of endocrine, inflammatory, and immune conditions as well as for palliation of neoplastic conditions. Betamethasone A systemic corticosteroid used to relieve inflammation in various conditions, including but not limited to allergic states, dermatologic disorders, gastrointestinal diseases, and hematological disorders. Anecortave acetate Investigated for use/treatment in glaucoma and macular degeneration. Fluclorolone acetonide Fluclorolone acetonide (INN) or flucloronide (USAN) is a topical corticosteroid. It is marketed under the brand names Cutanit and Topicon. Halometasone A corticosteroid indicated in the treatment of corticosteroid responsive dermatoses. Beclomethasone 17-monopropionate An ester of beclomethasone. Fluprednidene acetate A corticosteroid indicated in the treatment of corticosteroid-responsive dermatoses. Vamorolone Vamorolone is under investigation in clinical trial NCT03439670 (A Study to Assess the Efficacy and Safety of Vamorolone in Boys With Duchenne Muscular Dystrophy (DMD)). Flunisolide An inhaled corticosteroid used as a prophylactic therapy in the maintenance treatment of asthma. Fluorometholone An ophthalmic corticosteroid used for the relief of inflammation located in both the palpebral and bulbar conjunctiva, the cornea, and the anterior segment of the globe of the eye. Megestrol acetate A progestin that is administered orally to treat anorexia and cachexia or serious unexplained weight loss and is also used as an antineoplastic agent to treat certain types of malignancy. Dydrogesterone A synthetic progesterone for menstrual cycle regulation, infertility treatment, prevention of miscarriage, and other conditions. Flumethasone A corticosteroid used to treat contact dermatitis, atopic dermatitis, eczema, psoriasis, diaper rash, and other skin conditions. Eplerenone An aldosterone receptor antagonist used to improve survival of patients with symptomatic heart failure and to reduce blood pressure. Clocortolone A corticosteroid used to treat inflammatory and pruritic dermatoses of the scalp. Desoxycorticosterone pivalate Examined for treatment of adrenocortical insufficiency especially in multiple sclerosis, congenital cerebral palsy, polyarteritis nodosa, and rheumatoid arthritis. Currently only approved in treating cats and dogs for the treatment of... Desonide A topical corticosteroid used for the symptomatic treatment of inflammatory and pruritic manifestations of corticosteroid responsive dermatoses. Paramethasone For the treatment of all conditions in which corticosteroid therapy is indicated except adrenal-deficiency states for which its lack of sodium-retaining properties makes it less suitable than hydrocortisone with supplementary... Danazol A synthetic steroid and pituitary gonadotropin inhibitor used in the treatment of endometriosis and symptomatic treatment of severe pain and tenderness associated with benign fibrocystic breasts. Ciclesonide A glucocorticoid used in the symptomatic relief of nasal symptoms associated with seasonal and perennial allergic rhinitis in adults and adolescents. Pregnenolone A 21-carbon steroid, derived from cholesterol and found in steroid hormone-producing tissues. Pregnenolone is the precursor to gonadal steroid hormones and the adrenal corticosteroids. Aldosterone A hormone secreted by the adrenal cortex that regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium. Corticosterone An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1437) Cyproterone acetate A steroid used in combination with ethinyl estradiol to treat women with severe acne and symptoms of androgenization. Also used alone at much higher doses for palliative treatment of patients with prostate cancer Ganaxolone A neuroactive steroid GABA-A receptor modulator used for the treatment of seizures associated with CDKL5 deficiency disorder (CDD). NCX 1022 Investigated for use/treatment in atopic dermatitis. NCX 1015 Investigated for use/treatment in arthritis and arthritic pain and inflammatory bowel disease. Desoxycorticosterone acetate Not Annotated Halcinonide A corticosteroid used for the management and symptomatic relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Hydroxyprogesterone caproate A synthetic progestin used for the prevention of spontaneous preterm births in singleton pregnancies in women who have previously had a spontaneous preterm birth. Hydroxydione Hydroxydione (Viadril) is a neuroactive steroid used as a general anesthetic. Canrenoic acid An aldosterone antagonist used in primary hyperaldosteronism and other disorders related to aberrant aldosterone levels. Tixocortol A corticosteroid used for the symptomatic treatment of rhinitis, pharyngitis, and ulcerative colitis. Medrogestone A progestin used as an adjunct to control secondary amenorrhea and dysfunctional bleeding in adolescent and adult females, and treat endometrial shedding in menopausal women. Fluprednisolone A synthetic glucocorticoid with anti-inflammatory properties. Meprednisone Not Annotated Alfaxalone Alfaxalone, also known as alphaxalone or alphaxolone, is a neuroactive steroid and general anaesthetic. It is used in veterinary practice under the trade name Alfaxan, and is licensed for use... Norgestomet Norgestomet, also known as 11β-methyl-17-hydroxy-19-norprogesterone acetate, is a steroidal progestin used in veterinary medicine to control estrus and ovulation in cattle. Dexamethasone isonicotinate Dexamethasone isonicotinate is an anti-inflammatory, anti-allergic glucocorticoid that can be administered orally, by inhalation, topically, and parenterally. Its unintended mineralocorticoid action may cause salt and water retention. Isoflupredone Not Annotated Melengestrol Melengestrol is a steroidal progestin and antineoplastic agent which was never marketed. An acylated derivative, melengestrol acetate, is used as a growth promoter in animals. Nomegestrol Nomegestrol is an ingredient in the EMA-authorised product Zoely. Anecortave Anecortave is under investigation in clinical trial NCT00691717 (Anecortave Acetate Safety in Patients With Open-Angle Glaucoma or Ocular Hypertension). Canrenone An antimineralocorticoid and active metabolite of spironolactone used in the treatment of primary hyperaldosteronism and edematous states caused by secondary hyperaldosteronism (e.g. heart failure). Fluocinolone Fluocinolone has been used in trials studying the treatment and prevention of Candida Infection, Oral Lichen Planus, Macular Degeneration, and Choroidal Neovascularization. Prednimustine Prednimustine has been used in trials studying the treatment of Lymphoma. Cortivazol Cortivazol is under investigation in clinical trial NCT00804895 (Cluster Headache Cortivazol Injection (CHCI)). Tirilazad Tirilazad has been used in trials studying the treatment of Spinal Cord Injury. Prednylidene Prednylidene is an experimental systemic glucocorticoid. Chlormadinone A progestin indicated in combination with an estrogen for oral combined hormonal contraceptive therapy. Flumedroxone Not Annotated Cloprednol A glucocorticoid indicated in the treatment of arthritis and asthma. Nomegestrol acetate Nomegestrol acetate, also known as NOMAC, is a progestin used in oral contraceptives, menopausal hormone therapy, and for the treatment of gynecological disorders. Hydrocortisone aceponate For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also used to treat endocrine (hormonal) disorders (adrenal insufficiency, Addisons disease). It is also used to treat many... Hydrocortisone acetate A corticosteroid used to treat inflammatory and pruritic corticosteroid-responsive dermatoses and ulcerative colitis. Hydrocortisone butyrate A corticosteroid used to treat inflammatory and pruritic corticosteroid-responsive dermatoses. Hydrocortisone cypionate For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also used to treat endocrine (hormonal) disorders (adrenal insufficiency, Addisons disease). It is also used to treat many... Hydrocortisone phosphate A corticosteroid used to treat congenital adrenal hyperplasia, for emergency asthma treatment, hypersensitivity, and inflammation. Hydrocortisone probutate A corticosteroid used to treat inflammatory and pruritic corticosteroid-responsive dermatoses. Hydrocortisone valerate A corticosteroid used to treat inflammatory and pruritic corticosteroid-responsive dermatoses. Hydrocortisone succinate A corticosteroid used to treat severe allergic reactions, dermatologic diseases, endocrine disorders, gastrointestinal diseases, hematological disorders, neoplastic diseases, nervous system conditions, ophthalmic diseases, renal diseases, respiratory diseases, and rheumatic disorders. Hydroxyprogesterone Not Annotated Segesterone acetate Segesterone acetate in combination with ethinyl estradiol is indicated for use by females of reproductive potential to prevent pregnancy as a combination hormonal contraceptive (CHC). It induces contraception for thirteen... Prednisolone tebutate Not Annotated Prednisolone hemisuccinate A corticosteroid indicated in the treatment of anaphylaxis, asthma, edema, organ rejection, and other indications. Isoflupredone acetate Not Annotated Methylprednisolone aceponate A corticosteroid indicated in the treatment of corticosteroid-responsive dermatoses. Methylprednisolone hemisuccinate A water soluble corticosteroid used to treat severe allergic reactions, dermatologic diseases, endocrine disorders, gastrointestinal diseases, hematological disorders, neoplastic diseases, nervous system conditions, ophthalmic diseases, renal diseases, respiratory diseases, and rheumatic disorders. Prednisone acetate Not Annotated Dexamethasone acetate Commonly known as decadron, dexamethasone acetate is a glucocorticosteroid previously marketed in the USA for the treatment of inflammatory respiratory, allergic, autoimmune, and other conditions.[T797,L10695,L14348] Developed in 1957, dexamethasone is... Clocortolone acetate Not Annotated Paramethasone acetate Not Annotated Melengestrol acetate A 6-methyl progesterone acetate with reported glucocorticoid activity and effect on estrus. Flunisolide acetate Not Annotated Gestonorone caproate Not Annotated Cortisone A naturally occurring glucocorticoid. It has been used in replacement therapy for adrenal insufficiency and as an anti-inflammatory agent. Cortisone itself is inactive. It is converted in the liver to... Dexamethasone metasulfobenzoate An ophthalmic and auricular corticosteroid used with antibiotics for the treatment of otitis externa, blepharitis, and other inflammatory eye conditions. Algestone acetophenide A progestin indicated in combination with an estrogen as an injectable contraceptive. Fluocortolone pivalate A corticosteroid used to treat corticosteroid-responsive dermatoses and hemorrhoids. Fluocortolone caproate A corticosteroid indicated in the treatment of hemorrhoids, anal fissures, and corticosteroid-responsive dermatoses. Chlormadinone acetate A progestin indicated in combination with an estrogen for birth control. Desoxycortone Not Annotated
- Drugs & Drug Targets