Gastrointestinal Stromal Tumor (GIST)

Also known as: Gastro-intestinal Stromal Tumor / Gastrointestinal Stromal Tumor (GIST) of the Gastrointestinal Tract / Gastro Intestinal Stromal Tumor / Gastro-intestinal Stromal Tumors (GIST) / Gastrointestinal Stromal Tumor(GIST) / GIST - Gastrointestinal Stromal Tumor / Gastrointestinal Stromal Tumors / Gastrointestinal Stromal Tumour (GIST) / Gastrointestinal Stromal Tumor / Gastrointestinal Stromal Tumors (GIST) / Gastrointestinal Stromal Tumors (GISTs) / Gastrointenstinal Stromal Tumor (GIST) / Stromal Tumor of the Gastrointestinal Tract / Gastrointestinal Stromal Tumour / Gastrointestinal Stromal Tumours / Gastro Intestinal Stromal Tumour / Gastro-intestinal Stromal Tumours / Gastro-Intestinal Stromal Tumour / Gastrointestinal stromal tumor (morphologic abnormality) / Gastrointestinal stromal tumor (disorder) / Gastrointestinal Stromal Sarcoma / Gastrointestinal stromal sarcoma (morphologic abnormality)

DrugDrug NameDrug Description
DB00619ImatinibA tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors.
DB00398SorafenibA kinase inhibitor used in the treatment of unresectable liver carcinoma and advanced renal carcinoma.
DB01268SunitinibA receptor tyrosine kinase inhibitor and chemotherapeutic agent used for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST).
DrugDrug NameTargetType
DB00619ImatinibPlatelet-derived growth factor receptor betatarget
DB00619ImatinibTyrosine-protein kinase ABL1target
DB00619ImatinibMast/stem cell growth factor receptor Kittarget
DB00619ImatinibRET proto-oncogenetarget
DB00619ImatinibHigh affinity nerve growth factor receptortarget
DB00619ImatinibMacrophage colony-stimulating factor 1 receptortarget
DB00619ImatinibPlatelet-derived growth factor receptor alphatarget
DB00619ImatinibEpithelial discoidin domain-containing receptor 1target
DB00619ImatinibCytochrome P450 3A4enzyme
DB00619ImatinibBreakpoint cluster region proteintarget
DB00619ImatinibCytochrome P450 1A2enzyme
DB00619ImatinibCytochrome P450 2D6enzyme
DB00619ImatinibCytochrome P450 2C9enzyme
DB00619ImatinibCytochrome P450 2C19enzyme
DB00619ImatinibCytochrome P450 3A5enzyme
DB00619ImatinibCytochrome P450 3A7enzyme
DB00619ImatinibSolute carrier family 22 member 1transporter
DB00619ImatinibP-glycoprotein 1transporter
DB00619ImatinibSolute carrier family 22 member 2transporter
DB00619ImatinibATP-binding cassette sub-family G member 2transporter
DB00619ImatinibATP-binding cassette sub-family A member 3transporter
DB00619ImatinibSerum albumincarrier
DB00619ImatinibAlpha-1-acid glycoprotein 1carrier
DB00619ImatinibBile salt export pumptransporter
DB00619ImatinibCytochrome P450 2C8enzyme
DB00619ImatinibCanalicular multispecific organic anion transporter 1transporter
DB00619ImatinibMultidrug resistance-associated protein 1transporter
DB00619ImatinibSolute carrier family 22 member 5transporter
DB00619ImatinibSolute carrier organic anion transporter family member 1B3transporter
DB00619ImatinibMultidrug resistance-associated protein 4transporter
DB00619ImatinibSolute carrier organic anion transporter family member 1A2transporter
DB00619ImatinibDiscoidin domain-containing receptor 2target
DB00398SorafenibSerine/threonine-protein kinase B-raftarget
DB00398SorafenibReceptor-type tyrosine-protein kinase FLT3target
DB00398SorafenibRAF proto-oncogene serine/threonine-protein kinasetarget
DB00398SorafenibVascular endothelial growth factor receptor 3target
DB00398SorafenibPlatelet-derived growth factor receptor betatarget
DB00398SorafenibMast/stem cell growth factor receptor Kittarget
DB00398SorafenibVascular endothelial growth factor receptor 2target
DB00398SorafenibCytochrome P450 3A4enzyme
DB00398SorafenibUDP-glucuronosyltransferase 1-9enzyme
DB00398SorafenibCytochrome P450 2B6enzyme
DB00398SorafenibCytochrome P450 2C8enzyme
DB00398SorafenibCytochrome P450 3A5enzyme
DB00398SorafenibCytochrome P450 3A7enzyme
DB00398SorafenibCytochrome P450 2C9enzyme
DB00398SorafenibMultidrug resistance-associated protein 4transporter
DB00398SorafenibP-glycoprotein 1transporter
DB00398SorafenibCanalicular multispecific organic anion transporter 1transporter
DB00398SorafenibATP-binding cassette sub-family G member 2transporter
DB00398SorafenibCytochrome P450 1A2enzyme
DB00398SorafenibCytochrome P450 2C19enzyme
DB00398SorafenibCytochrome P450 2D6enzyme
DB00398SorafenibUDP-glucuronosyltransferase 1-1enzyme
DB00398SorafenibRalA-binding protein 1transporter
DB00398SorafenibFibroblast growth factor receptor 1target
DB00398SorafenibProto-oncogene tyrosine-protein kinase receptor Rettarget
DB00398SorafenibVascular endothelial growth factor receptor 1target
DB00398SorafenibSolute carrier organic anion transporter family member 1B1transporter
DB01268SunitinibPlatelet-derived growth factor receptor betatarget
DB01268SunitinibVascular endothelial growth factor receptor 1target
DB01268SunitinibVascular endothelial growth factor receptor 2target
DB01268SunitinibVascular endothelial growth factor receptor 3target
DB01268SunitinibMast/stem cell growth factor receptor Kittarget
DB01268SunitinibReceptor-type tyrosine-protein kinase FLT3target
DB01268SunitinibMacrophage colony-stimulating factor 1 receptortarget
DB01268SunitinibPlatelet-derived growth factor receptor alphatarget
DB01268SunitinibCytochrome P450 3A4enzyme
DB01268SunitinibCytochrome P450 3A5enzyme
DB01268SunitinibCytochrome P450 3A7enzyme
DB01268SunitinibMultidrug resistance-associated protein 4transporter
DB01268SunitinibP-glycoprotein 1transporter
DB01268SunitinibCanalicular multispecific organic anion transporter 1transporter
DB01268SunitinibATP-binding cassette sub-family G member 2transporter
DB01268SunitinibHepatocyte growth factor receptortarget
DrugDrug NamePhaseStatusCount
DB019337-Hydroxystaurosporine1Completed1
DB03496Alvocidib1Completed1
DB15233Avapritinib1Completed1
DB15233Avapritinib1Not Yet Recruiting1
DB00112Bevacizumab1Completed1
DB11967Binimetinib1Completed1
DB00002Cetuximab1Completed1
DB01254Dasatinib1Completed1
DB05928Dovitinib1Withdrawn1
DB00997Doxorubicin1Completed1
DB00530Erlotinib1Completed1
DB06091Evofosfamide1Unknown Status1
DB00544Fluorouracil1Completed2
DB00441Gemcitabine1Completed1
DB16185HQP13511Recruiting1
DB00619Imatinib1Completed5
DB00619Imatinib1Recruiting1
DB00619Imatinib1Terminated1
DB00619Imatinib1Withdrawn1
DB06186Ipilimumab1Completed1
DB00762Irinotecan1Completed2
DB00650Leucovorin1Completed2
DB10315Measles virus vaccine live attenuated1Recruiting1
DB00683Midazolam1Not Yet Recruiting1
DB04868Nilotinib1Completed2
DB00526Oxaliplatin1Completed1
DB01229Paclitaxel1Completed1
DB06641Perifosine1Completed1
DB12978Pexidartinib1Completed1
DB08896Regorafenib1Completed1
DB00912Repaglinide1Recruiting1
DB05626Retaspimycin1Completed1
DB11730Ribociclib1Recruiting1
DB14840Ripretinib1Active Not Recruiting1
DB14840Ripretinib1Recruiting1
DB00020Sargramostim1Completed1
DB14892Spartalizumab1Recruiting1
DB01268Sunitinib1Completed2
DB01268Sunitinib1Recruiting1
DB01268Sunitinib1Terminated1
DB14876TAS-1161Recruiting1
DB14989Umbralisib1Completed1
DB15233Avapritinib1 / 2Active Not Recruiting1
DB11945Avelumab1 / 2Recruiting1
DB11967Binimetinib1 / 2Active Not Recruiting1
DB11967Binimetinib1 / 2Withdrawn1
DB01590Everolimus1 / 2Completed1
DB00619Imatinib1 / 2Active Not Recruiting1
DB00619Imatinib1 / 2Completed2
DB00619Imatinib1 / 2Recruiting2
DB09037Pembrolizumab1 / 2Terminated1
DB12978Pexidartinib1 / 2Completed1
DB12978Pexidartinib1 / 2Terminated1
DB11870RG-47331 / 2Completed1
DB08896Regorafenib1 / 2Recruiting1
DB14840Ripretinib1 / 2Withdrawn1
DB11942Selinexor1 / 2Recruiting1
DB14892Spartalizumab1 / 2Recruiting1
DB01268Sunitinib1 / 2Completed2
DB16750THE-6301 / 2Recruiting1
DB08828Vismodegib1 / 2Completed1
DB11881AUY9222Completed1
DB11881AUY9222Unknown Status1
DB14866Amcasertib2Terminated1
DB11885Anlotinib2Recruiting1
DB11945Avelumab2Recruiting1
DB06626Axitinib2Recruiting1
DB12359BIIB0212Completed1
DB11105Benzalkonium2Terminated1
DB00112Bevacizumab2Completed1
DB06598Brostallicin2Completed1
DB01101Capecitabine2Completed1
DB00958Carboplatin2Completed2
DB04849Cediranib2Completed1
DB12033Cediranib2Completed1
DB00515Cisplatin2Completed1
DB01254Dasatinib2Completed2
DB05928Dovitinib2Completed2
DB11717Epacadostat2Completed1
DB11741Famitinib2Unknown Status1
DB00322Floxuridine2Completed1
DB12047Ganetespib2Completed1
DB11918Guadecitabine2Terminated1
DB00619Imatinib2Active Not Recruiting1
DB00619Imatinib2Completed14
DB00619Imatinib2Not Yet Recruiting2
DB00619Imatinib2Recruiting3
DB00619Imatinib2Terminated3
DB00619Imatinib2Unknown Status1
DB06186Ipilimumab2Completed1
DB06186Ipilimumab2Recruiting1
DB09078Lenvatinib2Recruiting1
DB06075Linsitinib2Completed1
DB11526Masitinib2Completed2
DB14123Menthol2Completed1
DB04868Nilotinib2Active Not Recruiting1
DB04868Nilotinib2Completed3
DB04868Nilotinib2Terminated2
DB06132Nivolumab2Completed1
DB09035Nivolumab2Completed1
DB09035Nivolumab2Recruiting1
DB00104Octreotide2Completed1
DB06043Olaratumab2Terminated1
DB06306Onalespib2Completed1
DB01229Paclitaxel2Completed1
DB01229Paclitaxel2Recruiting1
DB06589Pazopanib2Completed2
DB06589Pazopanib2Terminated1
DB06589Pazopanib2Withdrawn1
DB00022Peginterferon alfa-2b2Terminated1
DB09037Pembrolizumab2Completed1
DB06641Perifosine2Completed1
DB08901Ponatinib2Completed1
DB00635Prednisone2Completed1
DB08896Regorafenib2Completed3
DB08896Regorafenib2Recruiting3
DB14840Ripretinib2Completed2
DB06176Romidepsin2Completed1
DB06159Rubitecan2Completed1
DB06436Semaxanib2Completed1
DB00398Sorafenib2Active Not Recruiting1
DB00398Sorafenib2Completed1
DB01268Sunitinib2Completed4
DB01268Sunitinib2Recruiting1
DB00853Temozolomide2Completed1
DB00853Temozolomide2Recruiting1
DB06287Temsirolimus2Completed1
DB05109Trabectedin2Completed1
DB08911Trametinib2Withdrawn1
DB05294Vandetanib2Completed1
DB05146XL8202Completed1
DB00619Imatinib2 / 3Completed1
DB15233Avapritinib3Completed1
DB00112Bevacizumab3Terminated1
DB11741Famitinib3Recruiting1
DB00619Imatinib3Completed6
DB00619Imatinib3Not Yet Recruiting1
DB00619Imatinib3Recruiting1
DB00619Imatinib3Terminated7
DB00619Imatinib3Unknown Status1
DB00583Levocarnitine3Completed1
DB11526Masitinib3Completed1
DB11526Masitinib3Terminated2
DB04868Nilotinib3Completed3
DB04868Nilotinib3Terminated1
DB08896Regorafenib3Completed2
DB05626Retaspimycin3Terminated1
DB14840Ripretinib3Active Not Recruiting2
DB01268Sunitinib3Active Not Recruiting1
DB01268Sunitinib3Completed2
DB01268Sunitinib3Recruiting1
DB01268Sunitinib3Terminated1
DB15233Avapritinib4Active Not Recruiting1
DB00736Esomeprazole4Completed1
DB00619Imatinib4Completed1
DB04868Nilotinib4Active Not Recruiting1
DB08896Regorafenib4Completed1
DB15233AvapritinibNot AvailableApproved for Marketing1
DB15233AvapritinibNot AvailableRecruiting2
DB01254DasatinibNot AvailableUnknown Status1
DB01590EverolimusNot AvailableTemporarily Not Available1
DB00693FluoresceinNot AvailableRecruiting1
DB00619ImatinibNot AvailableCompleted1
DB00619ImatinibNot AvailableNo Longer Available1
DB00619ImatinibNot AvailableNot Yet Recruiting1
DB00619ImatinibNot AvailableRecruiting1
DB00619ImatinibNot AvailableUnknown Status1
DB16024Indocyanine greenNot AvailableRecruiting1
DB05296Motexafin lutetiumNot AvailableTerminated1
DB04868NilotinibNot AvailableCompleted1
DB08896RegorafenibNot AvailableCompleted1
DB08896RegorafenibNot AvailableNo Longer Available2
DB14840RipretinibNot AvailableApproved for Marketing1
DB14840RipretinibNot AvailableRecruiting1
DB01268SunitinibNot AvailableCompleted3
DB01268SunitinibNot AvailableNot Yet Recruiting1
DB01268SunitinibNot AvailableRecruiting1
DB01268SunitinibNot AvailableUnknown Status1
DB00135TyrosineNot AvailableRecruiting2