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Darigabat

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

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Identification

Generic Name
Darigabat
DrugBank Accession Number
DB18966
Background

Darigabat is under investigation in clinical trial NCT05941442 (A Study to Evaluate Efficacy, Safety, and Tolerability of Darigabat in Participants With Panic Disorder).

Type
Small Molecule
Groups
Investigational
Structure
3D
Similar Structures
Weight
Average: 440.49
Monoisotopic: 440.131839889
Chemical Formula
C22H21FN4O3S
Synonyms
  • 7-ethyl-4-(4'-(ethylsulfonyl)-6-fluoro-2'-methoxybiphenyl-3-yl)-7h-imidazo(4,5-c)-pyridazine
  • 7h-imidazo(4,5-c)pyridazine, 7-ethyl-4-(4'-(ethylsulfonyl)-6-fluoro-2'-methoxy(1,1'-biphenyl)-3-yl)-
External IDs
  • CVL-865
  • PF-06372865
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Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
O9BP19HZ3Q
CAS number
1614245-70-3
InChI Key
PTTQXDBPTFOCMT-UHFFFAOYSA-N
InChI
InChI=1S/C22H21FN4O3S/c1-4-27-13-24-21-18(12-25-26-22(21)27)14-6-9-19(23)17(10-14)16-8-7-15(11-20(16)30-3)31(28,29)5-2/h6-13H,4-5H2,1-3H3
IUPAC Name
SMILES
CCN1C=NC2=C(C=NN=C12)C1=CC=C(F)C(=C1)C1=CC=C(C=C1OC)S(=O)(=O)CC

References

General References
Not Available
ChemSpider
58950370
BindingDB
144227
ChEMBL
CHEMBL3647536
ZINC
ZINC000150064758
Wikipedia
Darigabat

Clinical Trials

Clinical Trials
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PhaseStatusPurposeConditionsCountStart DateWhy Stopped100+ additional columns
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2Active Not RecruitingTreatmentSeizures2somestatusstop reasonjust information to hide
2CompletedBasic ScienceReflex Epilepsy, Photosensitive1somestatusstop reasonjust information to hide
2CompletedTreatmentChronic Lower Back Pain (CLBP)1somestatusstop reasonjust information to hide
2RecruitingTreatmentPanic Disorder1somestatusstop reasonjust information to hide
2TerminatedTreatmentGeneralized Anxiety Disorder1somestatusstop reasonjust information to hide

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Drug created at June 27, 2024 17:06 / Updated at June 28, 2024 04:46