Seizures

Also known as: Seizure / Convulsions / Convulsion (NOS) / Convulsion / Convulsions NOS / Fit / Fitting / Convulsion disorder / Fits NOS

DrugDrug NameDrug Description
DB00574FenfluramineFenfluramine is a phenethylamine that is structurally similar to serotonin. Due to its ability to increase extracellular serotonin levels, modulate serotonergic and other neurologic receptors, and control neurotransmission, it is effective in treating pharmacoresistant seizures.
DB01320FosphenytoinAn antiepileptic agent used for the management of generalized convulsive status epilepticus and prevention and treatment of seizures occurring during neurosurgery.
DB00252PhenytoinAn anticonvulsant drug used in the prophylaxis and control of various types of seizures.
DB00599ThiopentalA barbiturate used to induce general anesthesia, treat convulsions, and reduce intracranial pressure.
DB00697TizanidineAn alpha-2 adrenergic agonist used for the short-term treatment of muscle spasticity.
DrugDrug NameTargetType
DB00574Fenfluramine5-hydroxytryptamine receptor 2Ctarget
DB00574Fenfluramine5-hydroxytryptamine receptor 2Btarget
DB00574FenfluramineCytochrome P450 2D6enzyme
DB00574FenfluramineSodium-dependent serotonin transportertarget
DB00574Fenfluramine5-hydroxytryptamine receptor 2Atarget
DB00574FenfluramineSodium-dependent serotonin transportertransporter
DB00574Fenfluramine5-hydroxytryptamine receptor 1Dtarget
DB00574FenfluramineSigma non-opioid intracellular receptor 1target
DB00574Fenfluramine5-hydroxytryptamine receptor 1Atarget
DB00574FenfluramineCytochrome P450 1A2enzyme
DB00574FenfluramineCytochrome P450 2B6enzyme
DB00574FenfluramineCytochrome P450 2C9enzyme
DB00574FenfluramineCytochrome P450 2C19enzyme
DB00574FenfluramineCytochrome P450 3A4enzyme
DB00574FenfluramineCytochrome P450 3A5enzyme
DB01320FosphenytoinSodium channel protein type 5 subunit alphatarget
DB01320FosphenytoinCytochrome P450 2C19enzyme
DB01320FosphenytoinCytochrome P450 2B6enzyme
DB01320FosphenytoinCytochrome P450 2C9enzyme
DB01320FosphenytoinCytochrome P450 3A4enzyme
DB01320FosphenytoinSerum albumincarrier
DB01320FosphenytoinCytochrome P450 1A2enzyme
DB01320FosphenytoinUDP-glucuronosyltransferase 1-6enzyme
DB01320FosphenytoinUDP-glucuronosyltransferase 1-9enzyme
DB01320FosphenytoinThyroxine-binding globulincarrier
DB00252PhenytoinSodium channel protein type 5 subunit alphatarget
DB00252PhenytoinSodium channel protein type 1 subunit alphatarget
DB00252PhenytoinCytochrome P450 2C8enzyme
DB00252PhenytoinCytochrome P450 2C19enzyme
DB00252PhenytoinCytochrome P450 2C9enzyme
DB00252PhenytoinCytochrome P450 2B6enzyme
DB00252PhenytoinCytochrome P450 3A5enzyme
DB00252PhenytoinSerum albumincarrier
DB00252PhenytoinCytochrome P450 3A4enzyme
DB00252PhenytoinSolute carrier organic anion transporter family member 1C1transporter
DB00252PhenytoinP-glycoprotein 1transporter
DB00252PhenytoinCanalicular multispecific organic anion transporter 1transporter
DB00252PhenytoinCytochrome P450 11B1, mitochondrialenzyme
DB00252PhenytoinCytochrome P450 3A7enzyme
DB00252PhenytoinNuclear receptor subfamily 1 group I member 2target
DB00252PhenytoinSodium channel subunit beta-1target
DB00252PhenytoinSodium channel protein type 3 subunit alphatarget
DB00252PhenytoinUDP-glucuronosyltransferase 1-1enzyme
DB00252PhenytoinUDP-glucuronosyltransferase 1-6enzyme
DB00252PhenytoinUDP-glucuronosyltransferase 1-9enzyme
DB00252PhenytoinThyroxine-binding globulincarrier
DB00252PhenytoinPotassium voltage-gated channel subfamily H member 2target
DB00252PhenytoinVoltage-dependent L-type calcium channeltarget
DB00252PhenytoinSodium channel protein type 2 subunit alphatarget
DB00252PhenytoinSodium channel protein type 8 subunit alphatarget
DB00252PhenytoinGABA(A) Receptortarget
DB00252PhenytoinCytochrome P450 1A2enzyme
DB00252PhenytoinCytochrome P450 2A6enzyme
DB00252PhenytoinCytochrome P450 2D6enzyme
DB00252PhenytoinCytochrome P450 2E1enzyme
DB00252PhenytoinEpoxide hydrolase 1enzyme
DB00252PhenytoinUDP-glucuronosyltransferase 1-4enzyme
DB00252PhenytoinCatechol O-methyltransferaseenzyme
DB00252PhenytoinNAD(P)H dehydrogenase [quinone] 1enzyme
DB00252PhenytoinCytochrome P450 2C18enzyme
DB00599ThiopentalGamma-aminobutyric acid receptor subunit alpha-1target
DB00599ThiopentalFatty-acid amide hydrolase 1target
DB00599ThiopentalGamma-aminobutyric acid receptor subunit alpha-2target
DB00599ThiopentalGamma-aminobutyric acid receptor subunit alpha-3target
DB00599ThiopentalGamma-aminobutyric acid receptor subunit alpha-4target
DB00599ThiopentalGamma-aminobutyric acid receptor subunit alpha-5target
DB00599ThiopentalGamma-aminobutyric acid receptor subunit alpha-6target
DB00599ThiopentalNeuronal acetylcholine receptor subunit alpha-4target
DB00599ThiopentalNeuronal acetylcholine receptor subunit alpha-7target
DB00599ThiopentalGlutamate receptor 2target
DB00599ThiopentalGlutamate receptor ionotropic, kainate 2target
DB00599ThiopentalCytochrome P450 3A Subfamilyenzyme
DB00599ThiopentalMuscarinic acetylcholine receptor M3target
DB00599ThiopentalCytochrome P450 2C19enzyme
DB00697TizanidineAlpha-2 adrenergic receptorstarget
DB00697TizanidineCytochrome P450 1A2enzyme
DB00697TizanidineNischarintarget
DB00697TizanidineAlpha-1 adrenergic receptorstarget
DrugDrug NamePhaseStatusCount
DB00887Bumetanide1Completed1
DB09061Cannabidiol1Completed2
DB01202Levetiracetam1Completed1
DB00683Midazolam1Completed1
DB00776Oxcarbazepine1Completed2
DB06201Rufinamide1Completed1
DB00273Topiramate1Completed1
DB00313Valproic acid1Completed1
DB09061Cannabidiol1 / 2Completed1
DB00555Lamotrigine1 / 2Completed1
DB01202Levetiracetam1 / 2Completed4
DB01202Levetiracetam1 / 2Recruiting1
DB08883Perampanel1 / 2Recruiting1
DB00316Acetaminophen2Recruiting1
DB00490Buspirone2Terminated1
DB00349Clobazam2Completed1
DB00829Diazepam2Completed1
DB00254Doxycycline2Unknown Status1
DB01050Ibuprofen2Recruiting1
DB01202Levetiracetam2Completed2
DB14009Medical Cannabis2Recruiting1
DB00683Midazolam2Completed1
DB08883Perampanel2Completed1
DB00230Pregabalin2Completed1
DB12646SGS-7422Completed1
DB12367Selurampanel2Completed1
DB00273Topiramate2Completed5
DB00169Cholecalciferol2 / 3Completed1
DB01202Levetiracetam2 / 3Withdrawn1
DB00186Lorazepam2 / 3Withdrawn1
DB09061Cannabidiol3Completed2
DB09061Cannabidiol3Enrolling by Invitation1
DB00564Carbamazepine3Completed2
DB12338Carisbamate3Terminated1
DB00349Clobazam3Completed1
DB00829Diazepam3Completed1
DB00593Ethosuximide3Completed1
DB04953Ezogabine3Completed2
DB00996Gabapentin3Completed1
DB00555Lamotrigine3Completed2
DB01202Levetiracetam3Terminated1
DB00186Lorazepam3Completed1
DB00230Pregabalin3Completed1
DB00273Topiramate3Completed10
DB00273Topiramate3Terminated1
DB00313Valproic acid3Completed2
DB04953Ezogabine4Terminated1
DB06218Lacosamide4Terminated1
DB01202Levetiracetam4Active Not Recruiting2
DB01202Levetiracetam4Recruiting1
DB01202Levetiracetam4Terminated1
DB01202Levetiracetam4Withdrawn1
DB00683Midazolam4Completed1
DB00252Phenytoin4Terminated2
DB00252Phenytoin4Unknown Status1
DB00230Pregabalin4Completed1
DB00273Topiramate4Completed1
DB00302Tranexamic acid4Recruiting1
DB00802AlfentanilNot AvailableCompleted1
DB00479AmikacinNot AvailableCompleted1
DB00513Aminocaproic acidNot AvailableCompleted1
DB00559BosentanNot AvailableCompleted1
DB00564CarbamazepineNot AvailableCompleted1
DB01413CefepimeNot AvailableCompleted1
DB00369CidofovirNot AvailableCompleted1
DB00537CiprofloxacinNot AvailableCompleted1
DB00363ClozapineNot AvailableCompleted1
DB00151CysteineNot AvailableWithdrawn1
DB11074DimethiconeNot AvailableCompleted1
DB00828FosfomycinNot AvailableCompleted1
DB00502HaloperidolNot AvailableCompleted1
DB01221KetamineNot AvailableCompleted1
DB00598LabetalolNot AvailableCompleted1
DB06218LacosamideNot AvailableCompleted1
DB01202LevetiracetamNot AvailableCompleted7
DB01202LevetiracetamNot AvailableWithdrawn1
DB08815LurasidoneNot AvailableCompleted1
DB00959MethylprednisoloneNot AvailableCompleted1
DB01618MolindoneNot AvailableCompleted1
DB00607NafcillinNot AvailableCompleted1
DB01115NifedipineNot AvailableCompleted1
DB00776OxcarbazepineNot AvailableCompleted3
DB00497OxycodoneNot AvailableCompleted1
DB00312PentobarbitalNot AvailableCompleted1
DB08883PerampanelNot AvailableNot Yet Recruiting1
DB08883PerampanelNot AvailableRecruiting1
DB00319PiperacillinNot AvailableCompleted1
DB00728RocuroniumNot AvailableCompleted1
DB00658SevelamerNot AvailableCompleted1
DB00421SpironolactoneNot AvailableCompleted1
DB01606TazobactamNot AvailableCompleted1
DB00684TobramycinNot AvailableCompleted1
DB00273TopiramateNot AvailableCompleted2
DB00302Tranexamic acidNot AvailableCompleted1
DB00302Tranexamic acidNot AvailableNot Yet Recruiting1
DB00313Valproic acidNot AvailableCompleted2
DB00512VancomycinNot AvailableCompleted1
DB01339VecuroniumNot AvailableCompleted1
DB00661VerapamilNot AvailableUnknown Status1
DB00682WarfarinNot AvailableCompleted1
DB00246ZiprasidoneNot AvailableCompleted1
DB00425ZolpidemNot AvailableCompleted1