- GABA Agents
- Accession Number
Substances used for their pharmacological actions on GABAergic systems. GABAergic agents include agonists, antagonists, degradation or uptake inhibitors, depleters, precursors, and modulators of receptor function.
Drug Drug Description Baclofen A GABA-ergic agonist used to manage severe spasticity of cerebral or spinal origin in adult and pediatric patients. Lorazepam A short-acting benzodiazepine commonly used to treat panic disorders, severe anxiety, and seizures. Temazepam A short-acting benzodiazepine commonly used to treat panic disorders, severe anxiety, and insomnia. Pentobarbital A barbiturate drug used to induce sleep, cause sedation, and control certain types of seizures. Alprazolam A triazolobenzodiazepine with intermediate onset commonly used to treat panic disorders and generalized anxiety in addition to anxiety associated with depression. Secobarbital A barbiturate used for the short-term treatment of insomnia. Zolpidem A sedative hypnotic used for the short-term treatment of insomnia to improve sleep latency. Chlordiazepoxide A benzodiazepine used to treat the withdrawal symptoms of acute alcoholism, to treat preoperative anxiety, and to treat anxiety over a short term period. Thiopental A barbiturate used to induce general anesthesia, treat convulsions, and reduce intracranial pressure. Clorazepic acid A benzodiazepine used to treat anxiety, partial seizures, and alcohol withdrawal. Midazolam A short-acting benzodiazepine with rapid onset that is commonly used in seizures, anesthesia and anxiety disorders. Flurazepam A long-acting benzodiazepine with a rapid onset of action that is commonly used to treat insomnia. Diazepam A long-acting benzodiazepine with rapid onset commonly used to treat panic disorders, severe anxiety, alcohol withdrawal, and seizures. Oxazepam An intermediate-acting benzodiazepine with slow onset commonly used to treat panic disorders, severe anxiety, alcohol withdrawals, and insomnia. Methylphenobarbital For the relief of anxiety, tension, and apprehension, also used as an anticonvulsant for the treatment of epilepsy. Triazolam A benzodiazepine used for short term treatment of insomnia. Tiagabine An antiepileptic used to treat partial seizures. Zaleplon A sedative used for short term treatment of insomnia in adults. Clonazepam A long-acting benzodiazepine with intermediate onset commonly used to treat panic disorders, severe anxiety, and seizures. Vigabatrin An irreversible GABA transaminase inhibitor used as an adjunct therapy to treat refractory complex partial seizures in patients ≥2 years unresponsive to alternatives. May also be used as monotherapy to treat infantile spasms in infants 1 month to 2 years. Thiamylal Used for the production of complete anaesthesia of short duration, for the induction of general anaesthesia, and for inducing a hypnotic state. Phenobarbital A long-lasting barbiturate and anticonvulsant used in the treatment of all types of seizures, except for absent seizures. Flumazenil A benzodiazepine antagonist that is used for the complete or partial reversal of the sedative effects caused by benzodiazepines in various clinical settings, such as induced general anesthesia for diagnostic and therapeutic procedures. Estazolam A benzodiazepine used for the short-term management of insomnia. Amobarbital A barbiturate derivative used for the induction of sedation during procedures, short-term management of insomnia, and acute management of refractory tonic-clonic seizures. Flunitrazepam A benzodiazepine used to manage anxiety disorders and insomnia. Bromazepam A short-acting benzodiazepine with intermediate onset commonly used to treat panic disorders and severe anxiety. Prazepam A benzodiazepine used to manage more severe forms of anxiety disorders. Nitrazepam A long-acting benzodiazepine with intermediate onset commonly used to treat panic disorders, severe anxiety, insomnia, and seizures. Pagoclone For the potential treatment of panic and anxiety disorders. gamma-Aminobutyric acid The most common inhibitory neurotransmitter in the central nervous system. Clobazam A benzodiazepine used as adjunct treatment in seizures associated with Lennox-Gastaut syndrome. Primidone An antiepileptic used to treat grand mal, psychomotor, and focal epileptic seizures. Remimazolam An ultra short-acting benzodiazepine used for the induction and maintenence of procedural sedation during short procedures. Valproic acid An anticonvulsant used to control complex partial seizures and both simple and complex absence seizures. Aminooxyacetic acid A compound that inhibits aminobutyrate aminotransferase activity in vivo, thereby raising the level of gamma-aminobutyric acid in tissues. [PubChem] Clozapine An atypical or second-generation antipsychotic drug used in treatment-resistant schizophrenia and to decrease suicide risk in schizophrenic patients. Picrotoxin Used internally for relieving respiratory distress. Also for use as an antidote in poisoning by CNS depressants, especially barbiturates. Progabide Indicated for the treatment of epilepsy. Hexobarbital For the induction of anesthesia prior to the use of other general anesthetic agents and for induction of anesthesia for short surgical, diagnostic, or therapeutic procedures associated with minimal painful... Barbital A long-acting barbiturate that depresses most metabolic processes at high doses. It is used as a hypnotic and sedative and may induce dependence. Barbital is also used in veterinary practice... SGS-742 Investigated for use/treatment in alzheimer's disease, attention deficit/hyperactivity disorder (ADHD), memory loss, and schizophrenia and schizoaffective disorders. Ganaxolone A neuroactive steroid GABA-A receptor modulator used for the treatment of seizures associated with CDKL5 deficiency disorder (CDD). AZD 3355 Investigated for use/treatment in gastroesophageal reflux disease (GERD). Clomethiazole Investigated for use/treatment in strokes. Tramiprosate Investigated for use/treatment in strokes and alzheimer's disease. Gaboxadol Investigated for use/treatment in sleep disorders and insomnia. Adipiplon Investigated for use/treatment in insomnia and sleep disorders. Arbaclofen Placarbil Investigated for the treatment of spasticity in multiple sclerosis, acute back spasms, and GERD. Zolazepam Zolazepam is a pyrazolodiazepinone derivative used as an anaesthetic in veterinary medicine. Zolazepam is typically used in combination with the NMDA antagonist tiletamine or the α2 adrenoceptor agonist xylazine. It... Bicuculline Bicuculline is a light-sensitive competitive antagonist of GABAA receptors. It was originally identified in 1932 in plant alkaloid extracts and has been isolated from Dicentra cucullaria, Adlumia fungosa, Fumariaceae, and... Brexanolone Brexanolone is a synthetic neuroactive steroid gamma-aminobutyric acid A (GABA(a)) receptor positive modulator indicated for the treatment of postpartum depression (PPD) in adult women [FDA Label][A176080, A176083, F4063, F4066, F4072]. Lesogaberan Lesogaberan has been used in trials studying the treatment and basic science of GERD, Reflux, Heartburn, Regurgitation, and Reflux Disease, among others. Muscimol Muscimol has been used in trials studying the treatment of Epilepsy and Parkinson's Disease. Indiplon Indiplon has been used in trials studying the treatment of Insomnia and Depression. Pentetrazol A cough suppressant. Medazepam A long-acting benzodiazepine used for its sedative and anxiolytic properties. Phenibut Not Annotated Nordazepam A benzodiazepine indicated in the treatment of insomnia. Pyrazolam Not Annotated ABP-700 ABP-700 is under investigation in clinical trial NCT02800590 (Study to Investigate the Safety and Efficacy of 3 Dosing Regimens of ABP-700 for Procedural Sedation in Adult Participants Undergoing Colonoscopy).
- Drugs & Drug Targets