- GABA Modulators
- Accession Number
Substances that do not act as agonists or antagonists but do affect the GAMMA-AMINOBUTYRIC ACID receptor-ionophore complex. GABA-A receptors (RECEPTORS, GABA-A) appear to have at least three allosteric sites at which modulators act: a site at which BENZODIAZEPINES act by increasing the opening frequency of GAMMA-AMINOBUTYRIC ACID-activated chloride channels; a site at which BARBITURATES act to prolong the duration of channel opening; and a site at which some steroids may act. GENERAL ANESTHETICS probably act at least partly by potentiating GABAergic responses, but they are not included here.
Drug Drug Description Lorazepam A short-acting benzodiazepine commonly used to treat panic disorders, severe anxiety, and seizures. Temazepam A short-acting benzodiazepine commonly used to treat panic disorders, severe anxiety, and insomnia. Pentobarbital A barbiturate drug used to induce sleep, cause sedation, and control certain types of seizures. Alprazolam A triazolobenzodiazepine with intermediate onset commonly used to treat panic disorders and generalized anxiety in addition to anxiety associated with depression. Secobarbital A barbiturate used for the short-term treatment of insomnia. Chlordiazepoxide A benzodiazepine used to treat the withdrawal symptoms of acute alcoholism, to treat preoperative anxiety, and to treat anxiety over a short term period. Thiopental A barbiturate used to induce general anesthesia, treat convulsions, and reduce intracranial pressure. Clorazepic acid A benzodiazepine used to treat anxiety, partial seizures, and alcohol withdrawal. Midazolam A short-acting injectable benzodiazepine with rapid onset that is commonly used in seizures, anesthesia and anxiety disorders. Flurazepam A long-acting benzodiazepine with a rapid onset of action that is commonly used to treat insomnia. Diazepam A long-acting benzodiazepine with rapid onset commonly used to treat panic disorders, severe anxiety, alcohol withdrawal, and seizures. Oxazepam An intermediate-acting benzodiazepine with slow onset commonly used to treat panic disorders, severe anxiety, alcohol withdrawals, and insomnia. Methylphenobarbital For the relief of anxiety, tension, and apprehension, also used as an anticonvulsant for the treatment of epilepsy. Triazolam A benzodiazepine used for short term treatment of insomnia. Zaleplon A sedative used for short term treatment of insomnia in adults. Clonazepam A long-acting benzodiazepine with intermediate onset commonly used to treat panic disorders, severe anxiety, and seizures. Phenobarbital A long-lasting barbiturate and anticonvulsant used in the treatment of all types of seizures, except for absent seizures. Flumazenil A benzodiazepine antagonist that is used for the complete or partial reversal of the sedative effects caused by benzodiazepines in various clinical settings, such as induced general anesthesia for diagnostic and therapeutic procedures. Estazolam A benzodiazepine used for the short-term management of insomnia. Amobarbital A barbiturate derivative used for the induction of sedation during procedures, short-term management of insomnia, and acute management of refractory tonic-clonic seizures. Hexobarbital For the induction of anesthesia prior to the use of other general anesthetic agents and for induction of anesthesia for short surgical, diagnostic, or therapeutic procedures associated with minimal painful... Flunitrazepam A benzodiazepine used to manage anxiety disorders and insomnia. Bromazepam A short-acting benzodiazepine with intermediate onset commonly used to treat panic disorders and severe anxiety. Prazepam A benzodiazepine used to manage more severe forms of anxiety disorders. Nitrazepam A long-acting benzodiazepine with intermediate onset commonly used to treat panic disorders, severe anxiety, insomnia, and seizures. Indiplon Indiplon has been used in trials studying the treatment of Insomnia and Depression. AZD-7325 AZD7325 is a high affinity, selective modulator of the GABAA receptor system. Brexanolone Brexanolone is a synthetic neuroactive steroid gamma-aminobutyric acid A (GABA(a)) receptor positive modulator indicated for the treatment of postpartum depression (PPD) in adult women [FDA Label][A176080, A176083, F4063, F4066, F4072]. Primidone An antiepileptic used to treat grand mal, psychomotor, and focal epileptic seizures. Cenobamate A small molecule drug indicated to treat partial onset seizures in adults. Remimazolam An ultra short-acting benzodiazepine used for the induction and maintenence of procedural sedation during short procedures. Ganaxolone A neuroactive steroid GABA-A receptor modulator used for the treatment of seizures associated with CDKL5 deficiency disorder (CDD). Thiamylal Used for the production of complete anaesthesia of short duration, for the induction of general anaesthesia, and for inducing a hypnotic state. Barbital A long-acting barbiturate that depresses most metabolic processes at high doses. It is used as a hypnotic and sedative and may induce dependence. Barbital is also used in veterinary practice... Clomethiazole Investigated for use/treatment in strokes. Zolazepam Zolazepam is a pyrazolodiazepinone derivative used as an anaesthetic in veterinary medicine. Zolazepam is typically used in combination with the NMDA antagonist tiletamine or the α2 adrenoceptor agonist xylazine. It... Medazepam A long-acting benzodiazepine used for its sedative and anxiolytic properties. Nordazepam A benzodiazepine indicated in the treatment of insomnia. Pyrazolam Not Annotated
- Drugs & Drug Targets