GABA Modulators
- Name
- GABA Modulators
- Accession Number
- DBCAT000453
- Description
Substances that do not act as agonists or antagonists but do affect the GAMMA-AMINOBUTYRIC ACID receptor-ionophore complex. GABA-A receptors (RECEPTORS, GABA-A) appear to have at least three allosteric sites at which modulators act: a site at which BENZODIAZEPINES act by increasing the opening frequency of GAMMA-AMINOBUTYRIC ACID-activated chloride channels; a site at which BARBITURATES act to prolong the duration of channel opening; and a site at which some steroids may act. GENERAL ANESTHETICS probably act at least partly by potentiating GABAergic responses, but they are not included here.
- Drugs
Drug Drug Description Alprazolam A triazolobenzodiazepine with intermediate onset commonly used to treat panic disorders and generalized anxiety in addition to anxiety associated with depression. Amobarbital A barbiturate derivative used for the induction of sedation during procedures, short-term management of insomnia, and acute management of refractory tonic-clonic seizures. AZD-7325 AZD7325 is a high affinity, selective modulator of the GABAA receptor system. Barbital A long-acting barbiturate that depresses most metabolic processes at high doses. It is used as a hypnotic and sedative and may induce dependence. Barbital is also used in veterinary practice... Brexanolone Brexanolone is a synthetic neuroactive steroid gamma-aminobutyric acid A (GABA(a)) receptor positive modulator indicated for the treatment of postpartum depression (PPD) in adult women [FDA Label] . Bromazepam A short-acting benzodiazepine with intermediate onset commonly used to treat panic disorders and severe anxiety. Cenobamate A small molecule drug indicated to treat partial onset seizures in adults. Chlordiazepoxide A benzodiazepine used to treat the withdrawal symptoms of acute alcoholism, to treat preoperative anxiety, and to treat anxiety over a short term period. Cipepofol An alkylphenol GABA-A positive allosteric modulator used for induction of general anesthesia in adults undergoing surgery. Clomethiazole Investigated for use/treatment in strokes. Clonazepam A long-acting benzodiazepine with intermediate onset commonly used to treat panic disorders, severe anxiety, and seizures. Clorazepic acid A benzodiazepine used to treat anxiety, partial seizures, and alcohol withdrawal. Darigabat Darigabat is under investigation in clinical trial NCT05941442 (A Study to Evaluate Efficacy, Safety, and Tolerability of Darigabat in Participants With Panic Disorder). Diazepam A long-acting benzodiazepine with rapid onset commonly used to treat panic disorders, severe anxiety, alcohol withdrawal, and seizures. Estazolam A benzodiazepine used for the short-term management of insomnia. Flumazenil A benzodiazepine antagonist that is used for the complete or partial reversal of the sedative effects caused by benzodiazepines in various clinical settings, such as induced general anesthesia for diagnostic and therapeutic procedures. Flunitrazepam A benzodiazepine used to manage anxiety disorders and insomnia. Flurazepam A long-acting benzodiazepine with a rapid onset of action that is commonly used to treat insomnia. Ganaxolone A neuroactive steroid GABA-A receptor modulator used for the treatment of seizures associated with CDKL5 deficiency disorder (CDD). Hexobarbital For the induction of anesthesia prior to the use of other general anesthetic agents and for induction of anesthesia for short surgical, diagnostic, or therapeutic procedures associated with minimal painful... Indiplon Indiplon has been used in trials studying the treatment of Insomnia and Depression. Lorazepam A short-acting benzodiazepine commonly used to treat panic disorders, severe anxiety, and seizures. Medazepam A long-acting benzodiazepine used for its sedative and anxiolytic properties. Methylphenobarbital For the relief of anxiety, tension, and apprehension, also used as an anticonvulsant for the treatment of epilepsy. Midazolam A short-acting benzodiazepine with rapid onset that is commonly used in seizures, anesthesia and anxiety disorders. Nitrazepam A long-acting benzodiazepine with intermediate onset commonly used to treat panic disorders, severe anxiety, insomnia, and seizures. Nordazepam A benzodiazepine indicated in the treatment of insomnia. Oxazepam An intermediate-acting benzodiazepine with slow onset commonly used to treat panic disorders, severe anxiety, alcohol withdrawals, and insomnia. Pentobarbital A barbiturate drug used to induce sleep, cause sedation, and control certain types of seizures. Phenobarbital A long-lasting barbiturate and anticonvulsant used in the treatment of all types of seizures, except for absent seizures. Phetharbital Phetharbital is a small molecule drug. Phetharbital has a monoisotopic molecular weight of 260.12 Da. Prazepam A benzodiazepine used to manage more severe forms of anxiety disorders. Primidone An antiepileptic used to treat grand mal, psychomotor, and focal epileptic seizures. Pyrazolam Not Annotated Remimazolam An ultra short-acting benzodiazepine used for the induction and maintenence of procedural sedation during short procedures. Secobarbital A barbiturate used for the short-term treatment of insomnia. Temazepam A short-acting benzodiazepine commonly used to treat panic disorders, severe anxiety, and insomnia. Thiamylal Used for the production of complete anaesthesia of short duration, for the induction of general anaesthesia, and for inducing a hypnotic state. Thiopental A barbiturate used to induce general anesthesia, treat convulsions, and reduce intracranial pressure. Triazolam A benzodiazepine used for short term treatment of insomnia. Zaleplon A sedative used for short term treatment of insomnia in adults. Zolazepam Zolazepam is a pyrazolodiazepinone derivative used as an anaesthetic in veterinary medicine. Zolazepam is typically used in combination with the NMDA antagonist tiletamine or the α2 adrenoceptor agonist xylazine. It... - Drugs & Drug Targets