p-Boronophenylalanine

DB19158InvestigationalSmall molecule

p-Boronophenylalanine is under investigation in clinical trial NCT00039572 (Boron Neutron Capture Therapy in Treating Patients With Glioblastoma Multiforme or Melanoma Metastatic to the Brain).

Mechanism: Pharmacologically active on Large neutral amino acids transporter small subunit 1
Curator reviewed
Formula / weight: C₉H₁₂BNO₄ · 209.01 g/mol (avg)
Also known as: 4-borono-l-phenylalanine · Borofalan · L-p-boronophenylalanine · L-phenylalanine, 4-borono-
Code names: L-BPA

Resolves to

Compound

UNIIJSM63LV5MDCAS76410-58-7ChEMBLCHEMBL125582

Structure

InChIKeyNFIVJOSXJDORSP-QMMMGPOBSA-NSMILESN[C@@H](CC1=CC=C(C=C1)B(O)O)C(O)=O

Targets

Q01650SLC7A5

What you can answer from here — as of July 09, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

3Clinical trialsPhase, status and sponsor resolved per trial

3+ReferencesStructured and connected to the statements they support

Which drugs share a target with p-Boronophenylalanine, and which of those have an active Phase 3 trial?

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