Radiation-Sensitizing Agents

Radiation-Sensitizing Agents
Accession Number

Drugs used to potentiate the effectiveness of radiation therapy in destroying unwanted cells.

DrugDrug Description
Porfimer sodiumA hematoporphyrin derivative used to treat esophageal cancer, endobronchial cancer, and high grade dysplasia in Barrett's Esophagus.
TrioxsalenA psoralen derivative that has been used in combination with UV light to treat vitiligo, but has been discontinued by its manufacturer.
AcetophenoneNot Available
TirapazamineFor the treatment of head and neck cancer.
PerflubronInvestigated for use/treatment in cardiac surgery, hemorrhage, and ileus.
TemoporfinA photosensitizer used to treat squamous cell carcinomas of the head and neck.
MisonidazoleMisonidazole is under investigation in clinical trial NCT00038038 (Assessment of Head and Neck Tumor Hypoxia Using 18F-Fluoromisonidazole).
SerdemetanSerdemetan has been used in trials studying the treatment of Neoplasms.
PimonidazolePimonidazole is under investigation for the diagnostic of Prostate Cancer and Head and Neck Cancer.
EtanidazoleEtanidazole has been used in trials studying the diagnostic of Adult Ependymoma, Malignant Ascites, Adult Gliosarcoma, Adult Mixed Glioma, and Adult Glioblastoma, among others.
PhthalocyaninePhthalocyanine is under investigation in clinical trial NCT00103246 (Photodynamic Therapy Using Silicon Phthalocyanine 4 in Treating Patients With Actinic Keratosis, Bowen's Disease, Skin Cancer, or Stage I or Stage II...
WortmanninWortmannin is a steroid metabolite of Penicillium funiculosum and Talaromyces wortmannii fungi. This drug acts as a nonspecific, covalent inhibitor of phosphoinositide 3-kinase enzymes (PI3Ks).
LapachoneLapachone has been used in trials studying the treatment of Cancer, Carcinoma, Advanced Solid Tumors, Head and Neck Neoplasms, and Carcinoma, Squamous Cell.
GiripladibGiripladib is under investigation in clinical trial NCT00396955 (A Study Comparing 4 Dose Regimens of PLA-695, Naproxen, and Placebo In Subjects With Osteoarthritis Of The Knee).
CisplatinA platinum based chemotherapy agent used to treat various sarcomas, carcinomas, lymphomas, and germ cell tumors.
TretazicarTretazicar is under investigation in clinical trial NCT00746590 (Study of Anti-tumour Effects and Safety of Prolarix™ in Hepatocellular Carcinoma).
IrofulvenInvestigated for use/treatment in brain cancer, breast cancer, endometrial cancer, liver cancer, lung cancer, ovarian cancer, pancreatic cancer, pediatric indications, prostate cancer, and sarcoma.
LonidamineInvestigated for use/treatment in benign prostatic hyperplasia, prostate disorders, and cancer/tumors (unspecified).
TezacitabineInvestigated for use/treatment in colorectal cancer, lung cancer, leukemia (unspecified), and gastric cancer.
RostaporfinInvestigated for use/treatment in macular degeneration.
EfaproxiralNot Available
Dimethyl fumarateA medication used to treat patients with the relapsing-remitting form of multiple sclerosis.
BroxuridineBroxuridine has been used in trials studying the treatment of Leukemia, Stage I Prostate Cancer, Stage IIB Prostate Cancer, and Stage IIA Prostate Cancer.
PlatinumPlatinum is under investigation for the treatment of Metastatic Breast Cancer, Non-small Cell Lung Cancer, Gastric Large Cell Neuroendocrine Carcinoma, Colorectal Large Cell Neuroendocrine Carcinoma, and Pancreatic Large Cell Neuroendocrine...
LisofyllineLisofylline has been investigated for the treatment of Type 1 Diabetes Mellitus.
Buthionine sulfoximineButhionine sulfoximine has been used in trials studying the treatment of Neuroblastoma and Melanoma (Skin).
HypericinHypericin is under investigation for the treatment of Cutaneous T-cell Lymphoma.
OrnidazoleA nitroimidazole agent indicated in the treatment of infections such as trichomoniasis, amebiasis, and giardiasis.
RiboflavinA vitamin used to correct vitamin B2 deficiency.
VerteporfinA benzoporphyrin derivative used to treat pathological myopia, ocular histoplasmosis, and choroidal neovascularization in macular degeneration.
MethoxsalenA furocoumarin used to treat psoriasis and vitiligo.
CarprofenFor use as a pain reliever in the treatment of joint pain and post-surgical pain.
Aminolevulinic acidA porphyrin precursor used to treat actinic keratosis of the face, scalp, and upper extremities, as well as to visualize a glioma.
Methyl aminolevulinateA porphyrin precursor used to treat non-hyperkeratotic, non-pigmented actinic keratosis of the face and scalp.
BenzophenoneAn ingredient used in sunscreens to absorb UV radiation.
ProtoporphyrinNot Available
Motexafin lutetiumInvestigated for use/treatment in brain cancer, breast cancer, cervical dysplasia/cancer, prostate cancer, cancer/tumors (unspecified), coronary artery disease, macular degeneration, and peripheral vascular disease.
Motexafin gadoliniumInvestigated for use/treatment in brain cancer, cancer/tumors (unspecified), lung cancer, and lymphoma (non-hodgkin's).
Titanium dioxideA sunscreen agent found in sunscreens that absorbs UV rays.
TalaporfinTalaporfin has been investigated for the treatment of Port-Wine Stain and Benign Prostatic Hyperplasia.
BergaptenBergapten is under investigation in clinical trial NCT00533195 (Comparison of UVA1 Phototherapy Versus Photochemotherapy for Patients With Severe Generalized Atopic Dermatitis).
Dihematoporphyrin etherDihematoporphyrin ether is under investigation in clinical trial NCT00118222 (High Light and Low Light Dose PDT in Glioma).
HemoporfinA porphyrin derivative combined with vitamin B12 for the treatment of asthenia.
AmotosalenNot Available
PsoralenNot Annotated
Drugs & Drug Targets
Porfimer sodiumLow-density lipoprotein receptortarget
Porfimer sodiumHigh affinity immunoglobulin gamma Fc receptor Itarget
AcetophenoneR-specific alcohol dehydrogenasetarget
TirapazamineCytochrome P450 2E1enzyme
WortmanninPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoformtarget
WortmanninSerine/threonine-protein kinase PLK1target
WortmanninPhosphatidylinositol 3-kinase regulatory subunit alphatarget
WortmanninPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformtarget
LapachoneRetinol-binding protein 3target
CisplatinCanalicular multispecific organic anion transporter 2transporter
CisplatinMultidrug resistance-associated protein 5transporter
CisplatinCanalicular multispecific organic anion transporter 1transporter
CisplatinSolute carrier family 22 member 2transporter
CisplatinHigh affinity copper uptake protein 1transporter
CisplatinProbable low affinity copper uptake protein 2transporter
CisplatinMultidrug resistance-associated protein 6transporter
CisplatinCopper-transporting ATPase 2transporter
CisplatinCopper-transporting ATPase 1transporter
CisplatinProstaglandin G/H synthase 2enzyme
CisplatinXanthine dehydrogenase/oxidaseenzyme
CisplatinArylamine N-acetyltransferaseenzyme
CisplatinCytochrome P450 2C9enzyme
CisplatinCytochrome P450 2B6enzyme
CisplatinCytochrome P450 4A11enzyme
CisplatinATP-binding cassette sub-family G member 2transporter
CisplatinGlutathione S-transferase theta-1enzyme
CisplatinSuperoxide dismutase [Cu-Zn]enzyme
CisplatinGlutathione S-transferase Penzyme
CisplatinNAD(P)H dehydrogenase [quinone] 1enzyme
CisplatinGlutathione S-transferase Mu 1enzyme
CisplatinDNA-3-methyladenine glycosylasetarget
CisplatinSerum albumincarrier
CisplatinCopper transport protein ATOX1target
TretazicarOxygen-insensitive NAD(P)H nitroreductasetarget
TretazicarRibosyldihydronicotinamide dehydrogenase [quinone]target
IrofulvenFar upstream element-binding protein 1target
LonidamineCystic fibrosis transmembrane conductance regulatortarget
TezacitabineRibonucleoside-diphosphate reductase large subunittarget
TezacitabineThymidine phosphorylaseenzyme
EfaproxiralHemoglobin subunit alphatarget
EfaproxiralHemoglobin subunit betatarget
Dimethyl fumarateKelch-like ECH-associated protein 1target
Dimethyl fumarateTranscription factor p65target
LisofyllineCytochrome P450 1A2enzyme
HypericinSerum albumincarrier
HypericinGlutathione S-transferase A1target
HypericinGlutathione S-transferase Ptarget
RiboflavinFlavin reductase (NADPH)target
RiboflavinRiboflavin kinasetarget
RiboflavinRiboflavin synthasetarget
RiboflavinAmine oxidase [flavin-containing] Aenzyme
RiboflavinMethylenetetrahydrofolate reductaseenzyme
RiboflavinSolute carrier family 22 member 6transporter
MethoxsalenCytochrome P450 2A6enzyme
MethoxsalenCytochrome P450 1A2enzyme
MethoxsalenCytochrome P450 1A1enzyme
MethoxsalenCytochrome P450 2A13enzyme
CarprofenProstaglandin G/H synthase 2target
CarprofenProstaglandin G/H synthase 1target
CarprofenSolute carrier family 22 member 6transporter
Aminolevulinic acidDelta-aminolevulinic acid dehydratasetarget
Aminolevulinic acidSolute carrier family 15 member 1transporter
Aminolevulinic acidSolute carrier family 15 member 2transporter
BenzophenoneEstrogen receptor alphatarget
BenzophenoneEstrogen receptor betatarget
ProtoporphyrinFerritin light chaintarget
Motexafin gadoliniumThioredoxin reductase 1, cytoplasmictarget
Motexafin gadoliniumThioredoxin reductase 2, mitochondrialtarget
Motexafin gadoliniumRibonucleoside-diphosphate reductase subunit M2target
Titanium dioxideMacrophage receptor MARCOtarget