Microsomal glutathione S-transferase 1

Details

Name
Microsomal glutathione S-transferase 1
Synonyms
  • 2.5.1.18
  • GST12
  • MGST
  • Microsomal GST-1
  • Microsomal GST-I
Gene Name
MGST1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0004480|Microsomal glutathione S-transferase 1
MVDLTQVMDDEVFMAFASYATIILSKMMLMSTATAFYRLTRKVFANPEDCVAFGKGENAK
KYLRTDDRVERVRRAHLNDLENIIPFLGIGLLYSLSGPDPSTAILHFRLFVGARIYHTIA
YLTPLPQPNRALSFFVGYGVTLSMAYRLLKSKLYL
Number of residues
155
Molecular Weight
17598.45
Theoretical pI
9.71
GO Classification
Functions
glutathione binding / glutathione peroxidase activity / glutathione transferase activity
Processes
cellular response to lipid hydroperoxide / glutathione derivative biosynthetic process / glutathione metabolic process / Leydig cell differentiation / oxidation-reduction process / protein homotrimerization / response to drug / response to lipopolysaccharide / response to organonitrogen compound / small molecule metabolic process / xenobiotic metabolic process
Components
apical part of cell / endoplasmic reticulum / endoplasmic reticulum membrane / integral component of membrane / mitochondrial inner membrane / mitochondrial outer membrane / mitochondrion / nucleus / peroxisomal membrane
General Function
Glutathione transferase activity
Specific Function
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a wide substrate specificity.
Pfam Domain Function
Transmembrane Regions
10-33 63-96 100-123 129-148
Cellular Location
Microsome
Gene sequence
>lcl|BSEQ0021668|Microsomal glutathione S-transferase 1 (MGST1)
ATGGTTGACCTCACCCAGGTAATGGATGATGAAGTATTCATGGCTTTTGCATCCTATGCA
ACAATTATTCTTTCAAAAATGATGCTTATGAGTACTGCAACTGCATTCTATAGATTGACA
AGAAAGGTTTTTGCCAATCCAGAAGACTGTGTAGCATTTGGCAAAGGAGAAAATGCCAAG
AAGTATCTTCGAACAGATGACAGAGTAGAACGTGTACGCAGAGCCCACCTGAATGACCTT
GAAAATATTATTCCATTTCTTGGAATTGGCCTCCTGTATTCCTTGAGTGGTCCCGACCCC
TCTACAGCCATCCTGCACTTCAGACTATTTGTCGGAGCACGGATCTACCACACCATTGCA
TATTTGACACCCCTTCCCCAGCCAAATAGAGCTTTGAGTTTTTTTGTTGGATATGGAGTT
ACTCTTTCCATGGCTTACAGGTTGCTGAAAAGTAAATTGTACCTGTAA
Chromosome Location
12
Locus
12p12.3-p12.1
External Identifiers
ResourceLink
UniProtKB IDP10620
UniProtKB Entry NameMGST1_HUMAN
GenBank Protein ID306808
GenBank Gene IDJ03746
GenAtlas IDMGST1
HGNC IDHGNC:7061
General References
  1. DeJong JL, Morgenstern R, Jornvall H, DePierre JW, Tu CP: Gene expression of rat and human microsomal glutathione S-transferases. J Biol Chem. 1988 Jun 15;263(17):8430-6. [Article]
  2. Kelner MJ, Stokely MN, Stovall NE, Montoya MA: Structural organization of the human microsomal glutathione S-transferase gene (GST12). Genomics. 1996 Aug 15;36(1):100-3. [Article]
  3. Lee SH, DeJong J: Microsomal GST-I: genomic organization, expression, and alternative splicing of the human gene. Biochim Biophys Acta. 1999 Sep 3;1446(3):389-96. [Article]
  4. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00143Glutathioneapproved, investigational, nutraceuticalunknownDetails
DB03310Glutathione disulfideapproved, experimental, investigationalunknownactivatorDetails
DB14924Ritlecitinibapproved, investigationalunknownsubstrateDetails