Neutral amino acid transporter A

Details

Name
Neutral amino acid transporter A
Synonyms
  • Alanine/serine/cysteine/threonine transporter 1
  • ASCT-1
  • ASCT1
  • SATT
  • Solute carrier family 1 member 4
Gene Name
SLC1A4
Organism
Humans
Amino acid sequence
>lcl|BSEQ0000958|Neutral amino acid transporter A
MEKSNETNGYLDSAQAGPAAGPGAPGTAAGRARRCAGFLRRQALVLLTVSGVLAGAGLGA
ALRGLSLSRTQVTYLAFPGEMLLRMLRMIILPLVVCSLVSGAASLDASCLGRLGGIAVAY
FGLTTLSASALAVALAFIIKPGSGAQTLQSSDLGLEDSGPPPVPKETVDSFLDLARNLFP
SNLVVAAFRTYATDYKVVTQNSSSGNVTHEKIPIGTEIEGMNILGLVLFALVLGVALKKL
GSEGEDLIRFFNSLNEATMVLVSWIMWYVPVGIMFLVGSKIVEMKDIIVLVTSLGKYIFA
SILGHVIHGGIVLPLIYFVFTRKNPFRFLLGLLAPFATAFATCSSSATLPSMMKCIEENN
GVDKRISRFILPIGATVNMDGAAIFQCVAAVFIAQLNNVELNAGQIFTILVTATASSVGA
AGVPAGGVLTIAIILEAIGLPTHDLPLILAVDWIVDRTTTVVNVEGDALGAGILHHLNQK
ATKKGEQELAEVKVEAIPNCKSEEETSPLVTHQNPAGPVASAPELESKESVL
Number of residues
532
Molecular Weight
55722.455
Theoretical pI
6.18
GO Classification
Functions
chloride channel activity / L-alanine transmembrane transporter activity / L-cystine transmembrane transporter activity / L-glutamine transmembrane transporter activity / L-hydroxyproline transmembrane transporter activity / L-proline transmembrane transporter activity / L-serine transmembrane transporter activity / L-threonine transmembrane transporter activity / sodium
Processes
amino acid transport / chloride transmembrane transport / chloride transport / cognition / glutamine transport / hydroxyproline transport / ion transport / L-alanine transport / L-cystine transport / L-serine transport / mitophagy in response to mitochondrial depolarization / proline transmembrane transport / proline transport / synaptic transmission, glutamatergic / threonine transport / transmembrane transport
Components
cell surface / centrosome / dendrite / extracellular exosome / integral component of membrane / integral component of plasma membrane / intermediate filament / melanosome / membrane / microtubule organizing center / neuronal cell body / plasma membrane
General Function
Sodium:dicarboxylate symporter activity
Specific Function
Transporter for alanine, serine, cysteine, and threonine. Exhibits sodium dependence.
Pfam Domain Function
Transmembrane Regions
42-62 88-108 119-139 217-237 257-277 298-318 328-348 373-393 418-438
Cellular Location
Membrane
Gene sequence
>lcl|BSEQ0020463|Neutral amino acid transporter A (SLC1A4)
ATGAACATTTTAGGATTGGTCCTGTTTGCTCTGGTGTTAGGAGTGGCCTTAAAGAAACTA
GGCTCCGAAGGAGAAGACCTCATCCGTTTCTTCAATTCCCTCAACGAGGCGACGATGGTG
CTGGTGTCCTGGATTATGTGCTCAGCGACCCTTCCCTCTATGATGAAGTGCATTGAAGAG
AACAATGGTGTGGACAAGAGGATCAGCAGGTTTATTCTCCCCATCGGGGCCACCGTGAAC
ATGGACGGAGCAGCCATCTTCCAGTGTGTGGCCGCGGTGTTCATTGCGCAACTCAACAAC
GTAGAGCTCAACGCAGGACAGATTTTCACCATTCTAGTGACTGCCACAGCGTCCAGTGTT
GGAGCAGCAGGCGTGCCAGCTGGAGGGGTCCTCACCATTGCCATTATCCTGGAGGCCATT
GGGCTGCCTACTCATGACCTGCCTCTGATCCTGGCTGTGGACTGGATTGTGGACCGGACC
ACCACGGTGGTGAATGTGGAAGGGGATGCCCTGGGTGCAGGCATTCTCCACCACCTGAAT
CAGAAGGCAACAAAGAAAGGCGAGCAGGAACTTGCTGAGGTGAAAGTGGAAGCCATCCCC
AACTGCAAGTCTGAGGAGGAGACATCGCCCCTGGTGACACACCAGAACCCCGCTGGCCCC
GTGGCCAGTGCCCCAGAACTGGAATCCAAGGAGTCGGTTCTGTGA
Chromosome Location
2
Locus
2p15-p13
External Identifiers
ResourceLink
UniProtKB IDP43007
UniProtKB Entry NameSATT_HUMAN
GenBank Protein ID348012
GenBank Gene IDL14595
GenAtlas IDSLC1A4
HGNC IDHGNC:10942
General References
  1. Arriza JL, Kavanaugh MP, Fairman WA, Wu YN, Murdoch GH, North RA, Amara SG: Cloning and expression of a human neutral amino acid transporter with structural similarity to the glutamate transporter gene family. J Biol Chem. 1993 Jul 25;268(21):15329-32. [Article]
  2. Shafqat S, Tamarappoo BK, Kilberg MS, Puranam RS, McNamara JO, Guadano-Ferraz A, Fremeau RT Jr: Cloning and expression of a novel Na(+)-dependent neutral amino acid transporter structurally related to mammalian Na+/glutamate cotransporters. J Biol Chem. 1993 Jul 25;268(21):15351-5. [Article]
  3. Hofmann K, Duker M, Fink T, Lichter P, Stoffel W: Human neutral amino acid transporter ASCT1: structure of the gene (SLC1A4) and localization to chromosome 2p13-p15. Genomics. 1994 Nov 1;24(1):20-6. [Article]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00160AlaninenutraceuticalunknownDetails