Neutral amino acid transporter A
Details
- Name
- Neutral amino acid transporter A
- Synonyms
- Alanine/serine/cysteine/threonine transporter 1
- ASCT-1
- ASCT1
- SATT
- Solute carrier family 1 member 4
- Gene Name
- SLC1A4
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0000958|Neutral amino acid transporter A MEKSNETNGYLDSAQAGPAAGPGAPGTAAGRARRCAGFLRRQALVLLTVSGVLAGAGLGA ALRGLSLSRTQVTYLAFPGEMLLRMLRMIILPLVVCSLVSGAASLDASCLGRLGGIAVAY FGLTTLSASALAVALAFIIKPGSGAQTLQSSDLGLEDSGPPPVPKETVDSFLDLARNLFP SNLVVAAFRTYATDYKVVTQNSSSGNVTHEKIPIGTEIEGMNILGLVLFALVLGVALKKL GSEGEDLIRFFNSLNEATMVLVSWIMWYVPVGIMFLVGSKIVEMKDIIVLVTSLGKYIFA SILGHVIHGGIVLPLIYFVFTRKNPFRFLLGLLAPFATAFATCSSSATLPSMMKCIEENN GVDKRISRFILPIGATVNMDGAAIFQCVAAVFIAQLNNVELNAGQIFTILVTATASSVGA AGVPAGGVLTIAIILEAIGLPTHDLPLILAVDWIVDRTTTVVNVEGDALGAGILHHLNQK ATKKGEQELAEVKVEAIPNCKSEEETSPLVTHQNPAGPVASAPELESKESVL
- Number of residues
- 532
- Molecular Weight
- 55722.455
- Theoretical pI
- 6.18
- GO Classification
- Functionschloride channel activity / L-alanine transmembrane transporter activity / L-cystine transmembrane transporter activity / L-glutamine transmembrane transporter activity / L-hydroxyproline transmembrane transporter activity / L-proline transmembrane transporter activity / L-serine transmembrane transporter activity / L-threonine transmembrane transporter activity / sodiumProcessesamino acid transport / chloride transmembrane transport / chloride transport / cognition / glutamine transport / hydroxyproline transport / ion transport / L-alanine transport / L-cystine transport / L-serine transport / mitophagy in response to mitochondrial depolarization / proline transmembrane transport / proline transport / synaptic transmission, glutamatergic / threonine transport / transmembrane transportComponentscell surface / centrosome / dendrite / extracellular exosome / integral component of membrane / integral component of plasma membrane / intermediate filament / melanosome / membrane / microtubule organizing center / neuronal cell body / plasma membrane
- General Function
- Sodium:dicarboxylate symporter activity
- Specific Function
- Transporter for alanine, serine, cysteine, and threonine. Exhibits sodium dependence.
- Pfam Domain Function
- SDF (PF00375)
- Transmembrane Regions
- 42-62 88-108 119-139 217-237 257-277 298-318 328-348 373-393 418-438
- Cellular Location
- Membrane
- Gene sequence
>lcl|BSEQ0020463|Neutral amino acid transporter A (SLC1A4) ATGAACATTTTAGGATTGGTCCTGTTTGCTCTGGTGTTAGGAGTGGCCTTAAAGAAACTA GGCTCCGAAGGAGAAGACCTCATCCGTTTCTTCAATTCCCTCAACGAGGCGACGATGGTG CTGGTGTCCTGGATTATGTGCTCAGCGACCCTTCCCTCTATGATGAAGTGCATTGAAGAG AACAATGGTGTGGACAAGAGGATCAGCAGGTTTATTCTCCCCATCGGGGCCACCGTGAAC ATGGACGGAGCAGCCATCTTCCAGTGTGTGGCCGCGGTGTTCATTGCGCAACTCAACAAC GTAGAGCTCAACGCAGGACAGATTTTCACCATTCTAGTGACTGCCACAGCGTCCAGTGTT GGAGCAGCAGGCGTGCCAGCTGGAGGGGTCCTCACCATTGCCATTATCCTGGAGGCCATT GGGCTGCCTACTCATGACCTGCCTCTGATCCTGGCTGTGGACTGGATTGTGGACCGGACC ACCACGGTGGTGAATGTGGAAGGGGATGCCCTGGGTGCAGGCATTCTCCACCACCTGAAT CAGAAGGCAACAAAGAAAGGCGAGCAGGAACTTGCTGAGGTGAAAGTGGAAGCCATCCCC AACTGCAAGTCTGAGGAGGAGACATCGCCCCTGGTGACACACCAGAACCCCGCTGGCCCC GTGGCCAGTGCCCCAGAACTGGAATCCAAGGAGTCGGTTCTGTGA
- Chromosome Location
- 2
- Locus
- 2p15-p13
- External Identifiers
Resource Link UniProtKB ID P43007 UniProtKB Entry Name SATT_HUMAN GenBank Protein ID 348012 GenBank Gene ID L14595 GenAtlas ID SLC1A4 HGNC ID HGNC:10942 - General References
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