Sulfotransferase 4A1

Details

Name
Sulfotransferase 4A1
Synonyms
  • 2.8.2.-
  • Brain sulfotransferase-like protein
  • hBR-STL
  • hBR-STL-1
  • Nervous system sulfotransferase
  • NST
  • ST4A1
  • SULTX3
Gene Name
SULT4A1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0052142|Sulfotransferase 4A1
MAESEAETPSTPGEFESKYFEFHGVRLPPFCRGKMEEIANFPVRPSDVWIVTYPKSGTSL
LQEVVYLVSQGADPDEIGLMNIDEQLPVLEYPQPGLDIIKELTSPRLIKSHLPYRFLPSD
LHNGDSKVIYMARNPKDLVVSYYQFHRSLRTMSYRGTFQEFCRRFMNDKLGYGSWFEHVQ
EFWEHRMDSNVLFLKYEDMHRDLVTMVEQLARFLGVSCDKAQLEALTEHCHQLVDQCCNA
EALPVGRGRVGLWKDIFTVSMNEKFDLVYKQKMGKCDLTFDFYL
Number of residues
284
Molecular Weight
33084.615
Theoretical pI
Not Available
GO Classification
Functions
identical protein binding / sulfotransferase activity
Processes
3'-phosphoadenosine 5'-phosphosulfate metabolic process / steroid metabolic process
Components
cytosol
General Function
Atypical sulfotransferase family member with very low affinity for 3'-phospho-5'-adenylyl sulfate (PAPS) and very low catalytic activity towards L-triiodothyronine, thyroxine, estrone, p-nitrophenol, 2-naphthylamine, and 2-beta-naphthol. May have a role in the metabolism of drugs and neurotransmitters in the CNS.
Specific Function
Identical protein binding
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0052143|Sulfotransferase 4A1 (SULT4A1)
ATGGCGGAGAGCGAGGCCGAGACCCCCAGCACCCCGGGGGAGTTCGAGAGCAAGTACTTC
GAGTTCCATGGCGTGCGGCTGCCGCCCTTCTGCCGCGGGAAGATGGAGGAGATCGCCAAC
TTCCCGGTGCGGCCCAGCGACGTGTGGATCGTCACCTACCCCAAGTCCGGCACCAGCTTG
CTGCAGGAGGTGGTCTACTTGGTGAGCCAGGGCGCTGACCCCGATGAGATCGGCTTGATG
AACATCGACGAGCAGCTCCCGGTCCTGGAGTACCCACAGCCGGGCCTGGACATCATCAAG
GAACTGACCTCTCCCCGCCTCATCAAGAGCCACCTGCCCTACCGCTTTCTGCCCTCTGAC
CTCCACAATGGAGACTCCAAGGTCATCTATATGGCTCGCAACCCCAAGGATCTGGTGGTG
TCTTATTATCAGTTCCACCGCTCTCTGCGGACCATGAGCTACCGAGGCACCTTTCAAGAA
TTCTGCCGGAGGTTTATGAATGATAAGCTGGGCTACGGCTCCTGGTTTGAGCACGTGCAG
GAGTTCTGGGAGCACCGCATGGACTCGAACGTGCTTTTTCTCAAGTATGAAGACATGCAT
CGGGACCTGGTGACGATGGTGGAGCAGCTGGCCAGATTCCTGGGGGTGTCCTGTGACAAG
GCCCAGCTGGAAGCCCTGACGGAGCACTGCCACCAGCTGGTGGACCAGTGCTGCAACGCT
GAGGCCCTGCCCGTGGGCCGGGGAAGAGTTGGGCTGTGGAAGGACATCTTCACCGTCTCC
ATGAATGAGAAGTTTGACTTGGTGTATAAACAGAAGATGGGAAAGTGTGACCTCACGTTT
GACTTTTATTTATAA
Chromosome Location
22
Locus
22q13.31
External Identifiers
ResourceLink
UniProtKB IDQ9BR01
UniProtKB Entry NameST4A1_HUMAN
HGNC IDHGNC:14903
General References
  1. Falany CN, Xie X, Wang J, Ferrer J, Falany JL: Molecular cloning and expression of novel sulphotransferase-like cDNAs from human and rat brain. Biochem J. 2000 Mar 15;346 Pt 3:857-64. [Article]
  2. Sakakibara Y, Suiko M, Pai TG, Nakayama T, Takami Y, Katafuchi J, Liu MC: Highly conserved mouse and human brain sulfotransferases: molecular cloning, expression, and functional characterization. Gene. 2002 Feb 20;285(1-2):39-47. doi: 10.1016/s0378-1119(02)00431-6. [Article]
  3. Collins JE, Goward ME, Cole CG, Smink LJ, Huckle EJ, Knowles S, Bye JM, Beare DM, Dunham I: Reevaluating human gene annotation: a second-generation analysis of chromosome 22. Genome Res. 2003 Jan;13(1):27-36. [Article]
  4. Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I: A genome annotation-driven approach to cloning the human ORFeome. Genome Biol. 2004;5(10):R84. Epub 2004 Sep 30. [Article]
  5. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
  6. Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al.: The DNA sequence of human chromosome 22. Nature. 1999 Dec 2;402(6761):489-95. [Article]
  7. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  8. Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal. 2009 Aug 18;2(84):ra46. doi: 10.1126/scisignal.2000007. [Article]
  9. Allali-Hassani A, Pan PW, Dombrovski L, Najmanovich R, Tempel W, Dong A, Loppnau P, Martin F, Thornton J, Edwards AM, Bochkarev A, Plotnikov AN, Vedadi M, Arrowsmith CH: Structural and chemical profiling of the human cytosolic sulfotransferases. PLoS Biol. 2007 May;5(5):e97. doi: 10.1371/journal.pbio.0050097. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00871TerbutalineapprovedunknownsubstrateDetails
DB00960Pindololapproved, investigationalunknownsubstrateDetails
DB00968MethyldopaapprovednosubstrateDetails
DB12471Ibrexafungerpapproved, investigationalunknownsubstrateDetails
DB00867Ritodrineapproved, investigationalnosubstrateDetails
DB12243Edaravoneapproved, investigationalnosubstrateDetails