Reaction: Tretinoin to 1 product
- Reaction
- Reaction type
- 4-hydroxylation
- Direction
- Not Available
- Major circulating metabolite?
- No
- Spontaneous?
- No
- Activity
- unknown
- References
- Marill J, Idres N, Capron CC, Nguyen E, Chabot GG: Retinoic acid metabolism and mechanism of action: a review. Curr Drug Metab. 2003 Feb;4(1):1-10. doi: 10.2174/1389200033336900. [Article]
- Marill J, Cresteil T, Lanotte M, Chabot GG: Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites. Mol Pharmacol. 2000 Dec;58(6):1341-8. [Article]
- Marill J, Capron CC, Idres N, Chabot GG: Human cytochrome P450s involved in the metabolism of 9-cis- and 13-cis-retinoic acids. Biochem Pharmacol. 2002 Mar 1;63(5):933-43. doi: 10.1016/s0006-2952(01)00925-x. [Article]
- Lee SJ, Perera L, Coulter SJ, Mohrenweiser HW, Jetten A, Goldstein JA: The discovery of new coding alleles of human CYP26A1 that are potentially defective in the metabolism of all-trans retinoic acid and their assessment in a recombinant cDNA expression system. Pharmacogenet Genomics. 2007 Mar;17(3):169-80. doi: 10.1097/FPC.0b013e32801152d6. [Article]
- Heise R, Mey J, Neis MM, Marquardt Y, Joussen S, Ott H, Wiederholt T, Kurschat P, Megahed M, Bickers DR, Merk HF, Baron JM: Skin retinoid concentrations are modulated by CYP26AI expression restricted to basal keratinocytes in normal human skin and differentiated 3D skin models. J Invest Dermatol. 2006 Nov;126(11):2473-80. doi: 10.1038/sj.jid.5700432. Epub 2006 Jun 15. [Article]
- Regazzi MB, Iacona I, Gervasutti C, Lazzarino M, Toma S: Clinical pharmacokinetics of tretinoin. Clin Pharmacokinet. 1997 May;32(5):382-402. doi: 10.2165/00003088-199732050-00004. [Article]
- FDA Approved Drug Products: VESANOID (tretinoin) capsules, for oral use [Link]
- Comments
- Not Available
- Enzymes
Enzyme Km Vmax Role Cytochrome P450 2C8 Not Available Not Available implied Cytochrome P450 3A4 Not Available Not Available implied Cytochrome P450 3A5 Not Available Not Available implied Cytochrome P450 3A7 Not Available Not Available implied Cytochrome P450 2C18 Not Available Not Available implied Cytochrome P450 4A11 Not Available Not Available implied Cytochrome P450 1A1 Not Available Not Available implied Cytochrome P450 2B6 Not Available Not Available implied
