Cytochrome P450 3A7

BE0003612ProteinHumansCYP3A7

A cytochrome P450 monooxygenase involved in the metabolism of steroid hormones and vitamins during embryogenesis (PubMed:11093772, PubMed:12865317, PubMed:14559847, PubMed:17178770, PubMed:9555064). It is acted on by 140 drugs in DrugBank.

Gene name
CYP3A7
UniProtKB entry
P24462Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
503 residues · 57,470 Da
Also known as
1.14.14.1 · CYPIIIA7 · Cytochrome P450-HFLA · P450HLp2

Resolves to

Protein
UniProtP24462UniProt nameCP3A7_HUMAN
Gene
HGNCHGNC:2640NCBI Gene1551GenBank220149GeneCardsCYP3A7
Pharmacology
KEGGhsa:1551
Structure
PDB7MK8PDB8GK3
Drugs

What you can answer from here — as of September 07, 2019

140DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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45Metabolic reactionsDrug transformations it catalyses, substrate to product
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13GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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188+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Cytochrome P450 3A7, how selective are they, and which programs against it are still in active trials?

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