Cytochrome P450 3A7
Details
- Name
- Cytochrome P450 3A7
- Kind
- protein
- Synonyms
- 1.14.14.1
- CYPIIIA7
- Cytochrome P450-HFLA
- P450HLp2
- Gene Name
- CYP3A7
- UniProtKB Entry
- P24462Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0055995|Cytochrome P450 3A7 MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRKGYWTF DMECYKKYRKVWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKNAISI AEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYS MDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPILEALNITV FPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSI IFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVV NETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFS KKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFG GLLLTEKPIVLKAESRDETVSGA
- Number of residues
- 503
- Molecular Weight
- 57469.95
- Theoretical pI
- 9.59
- GO Classification
- Functionsall-trans retinoic acid 18-hydroxylase activity / estrogen 16-alpha-hydroxylase activity / estrogen 2-hydroxylase activity / retinoic acid 4-hydroxylase activity / steroid hydroxylase activity / testosterone 6-beta-hydroxylase activityProcessesestrogen metabolic process / lipid hydroxylation / oxidative demethylation / retinoic acid metabolic process / retinol metabolic process / steroid biosynthetic process / steroid metabolic process
- General Function
- A cytochrome P450 monooxygenase involved in the metabolism of steroid hormones and vitamins during embryogenesis (PubMed:11093772, PubMed:12865317, PubMed:14559847, PubMed:17178770, PubMed:9555064). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:11093772, PubMed:12865317, PubMed:14559847, PubMed:17178770, PubMed:9555064). Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes 3beta-hydroxyandrost-5-en-17-one (dehydroepiandrosterone, DHEA), a precursor in the biosynthesis of androgen and estrogen steroid hormones (PubMed:17178770, PubMed:9555064). Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1), particularly D-ring hydroxylated estrone at the C16-alpha position (PubMed:12865317, PubMed:14559847). Mainly hydroxylates all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may play a role in atRA clearance during fetal development (PubMed:11093772). Also involved in the oxidative metabolism of xenobiotics including anticonvulsants (PubMed:9555064)
- Specific Function
- all-trans retinoic acid 18-hydroxylase activity
- Pfam Domain Function
- p450 (PF00067)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Endoplasmic reticulum membrane
- Gene sequence
>lcl|BSEQ0019448|Cytochrome P450 3A7 (CYP3A7) ATGGATCTCATCCCAAACTTGGCCGTGGAAACCTGGCTTCTCCTGGCTGTCAGCCTGATA CTCCTCTATCTATATGGAACCCGTACACATGGACTTTTTAAGAAGCTTGGAATTCCAGGG CCCACACCTCTGCCTTTTTTGGGAAATGCTTTGTCCTTCCGTAAGGGCTATTGGACGTTT GACATGGAATGTTATAAAAAGTATAGAAAAGTCTGGGGTATTTATGACTGTCAACAGCCT ATGCTGGCTATCACAGATCCCGACATGATCAAAACAGTGCTAGTGAAAGAATGTTATTCT GTCTTCACAAACCGGAGGCCTTTCGGGCCAGTGGGATTTATGAAAAATGCCATCTCTATA GCTGAGGATGAAGAATGGAAGAGAATACGATCATTGCTGTCTCCAACATTCACCAGCGGA AAACTCAAGGAGATGGTCCCTATCATTGCCCAGTATGGAGATGTGTTGGTGAGAAATCTG AGGCGGGAAGCAGAGACAGGCAAGCCTGTCACCTTGAAACACGTCTTTGGGGCCTACAGC ATGGATGTGATCACTAGCACATCATTTGGAGTGAGCATCGACTCTCTCAACAATCCACAA GACCCCTTTGTGGAAAACACCAAGAAGCTTTTAAGATTTAATCCATTAGATCCATTCGTT CTCTCAATAAAAGTCTTTCCATTCCTTACCCCAATTCTTGAAGCATTAAATATCACTGTG TTTCCAAGAAAAGTTATAAGTTTTCTAACAAAATCTGTAAAACAGATAAAAGAAGGTCGC CTCAAAGAGACACAAAAGCACCGAGTGGATTTCCTTCAGCTGATGATTGACTCTCAGAAT TCAAAAGACTCTGAGACCCACAAAGCTCTGTCTGATCTGGAGCTCATGGCCCAATCAATT ATCTTTATTTTTGCTGGCTATGAAACCACGAGCAGTGTTCTCTCCTTCATTATATATGAA CTGGCCACTCACCCTGATGTCCAGCAGAAAGTGCAGAAGGAAATTGATACAGTTTTACCC AATAAGGCACCACCCACCTATGATACTGTGCTACAGTTGGAGTATCTTGACATGGTGGTG AATGAAACACTCAGATTATTCCCAGTTGCTATGAGACTTGAGAGGGTCTGCAAAAAAGAT GTTGAAATCAATGGGATGTTTATTCCCAAAGGGGTGGTGGTGATGATTCCAAGCTATGTT CTTCATCATGACCCAAAGTACTGGACAGAGCCTGAGAAGTTCCTCCCTGAAAGGTTCAGT AAAAAGAACAAGGACAACATAGATCCTTACATATACACACCCTTTGGAAGTGGACCCAGA AACTGCATTGGCATGAGGTTTGCTCTCGTGAACATGAAACTTGCTCTAGTCAGAGTCCTT CAGAACTTCTCCTTCAAACCTTGTAAAGAAACACAGATCCCCCTGAAATTACGCTTTGGA GGACTTCTTCTAACAGAAAAACCCATTGTTCTAAAGGCTGAGTCAAGGGATGAGACCTTT GTAGATATGGAGCCCATTCACATGGACTTTTTAAGAAGCTTGGCATTCCAGGGCCCACAC CTCTGCTTTTTTTGGGAACTACTTTGTCCTACCATCAGATCCCGCTGA
- Chromosome Location
- 7
- Locus
- 7q22.1
- External Identifiers
Resource Link UniProtKB ID P24462 UniProtKB Entry Name CP3A7_HUMAN GenBank Protein ID 220149 GenBank Gene ID D00408 GeneCard ID CYP3A7 HGNC ID HGNC:2640 PDB ID(s) 7MK8 KEGG ID hsa:1551 NCBI Gene ID 1551 - General References
- Komori M, Nishio K, Ohi H, Kitada M, Kamataki T: Molecular cloning and sequence analysis of cDNA containing the entire coding region for human fetal liver cytochrome P-450. J Biochem. 1989 Feb;105(2):161-3. [Article]
- Finta C, Zaphiropoulos PG: The human cytochrome P450 3A locus. Gene evolution by capture of downstream exons. Gene. 2000 Dec 30;260(1-2):13-23. [Article]
- Gellner K, Eiselt R, Hustert E, Arnold H, Koch I, Haberl M, Deglmann CJ, Burk O, Buntefuss D, Escher S, Bishop C, Koebe HG, Brinkmann U, Klenk HP, Kleine K, Meyer UA, Wojnowski L: Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene. Pharmacogenetics. 2001 Mar;11(2):111-21. [Article]
- Scherer SW, Cheung J, MacDonald JR, Osborne LR, Nakabayashi K, Herbrick JA, Carson AR, Parker-Katiraee L, Skaug J, Khaja R, Zhang J, Hudek AK, Li M, Haddad M, Duggan GE, Fernandez BA, Kanematsu E, Gentles S, Christopoulos CC, Choufani S, Kwasnicka D, Zheng XH, Lai Z, Nusskern D, Zhang Q, Gu Z, Lu F, Zeesman S, Nowaczyk MJ, Teshima I, Chitayat D, Shuman C, Weksberg R, Zackai EH, Grebe TA, Cox SR, Kirkpatrick SJ, Rahman N, Friedman JM, Heng HH, Pelicci PG, Lo-Coco F, Belloni E, Shaffer LG, Pober B, Morton CC, Gusella JF, Bruns GA, Korf BR, Quade BJ, Ligon AH, Ferguson H, Higgins AW, Leach NT, Herrick SR, Lemyre E, Farra CG, Kim HG, Summers AM, Gripp KW, Roberts W, Szatmari P, Winsor EJ, Grzeschik KH, Teebi A, Minassian BA, Kere J, Armengol L, Pujana MA, Estivill X, Wilson MD, Koop BF, Tosi S, Moore GE, Boright AP, Zlotorynski E, Kerem B, Kroisel PM, Petek E, Oscier DG, Mould SJ, Dohner H, Dohner K, Rommens JM, Vincent JB, Venter JC, Li PW, Mural RJ, Adams MD, Tsui LC: Human chromosome 7: DNA sequence and biology. Science. 2003 May 2;300(5620):767-72. Epub 2003 Apr 10. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- Wrighton SA, Vandenbranden M: Isolation and characterization of human fetal liver cytochrome P450HLp2: a third member of the P450III gene family. Arch Biochem Biophys. 1989 Jan;268(1):144-51. [Article]
- Komori M, Nishio K, Fujitani T, Ohi H, Kitada M, Mima S, Itahashi K, Kamataki T: Isolation of a new human fetal liver cytochrome P450 cDNA clone: evidence for expression of a limited number of forms of cytochrome P450 in human fetal livers. Arch Biochem Biophys. 1989 Jul;272(1):219-25. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Erythromycin approved, investigational, vet_approved no enzyme substrateinhibitor Details Quinidine approved, investigational unknown enzyme substrate Details Alprazolam approved, illicit, investigational unknown enzyme substrate Details Diazepam approved, illicit, investigational, vet_approved unknown enzyme substrate Details Triazolam approved, investigational unknown enzyme substrate Details Indinavir approved unknown enzyme inhibitor Details Nelfinavir approved no enzyme inhibitor Details Saquinavir approved, investigational unknown enzyme substrateinhibitor Details Cisapride approved, investigational, withdrawn unknown enzyme substrate Details Astemizole approved, withdrawn unknown enzyme substrate Details Chlorpheniramine approved unknown enzyme substrate Details Terfenadine approved, withdrawn unknown enzyme substrate Details Diltiazem approved, investigational unknown enzyme substrateinhibitor Details Felodipine approved, investigational unknown enzyme substrate Details Lercanidipine approved, investigational unknown enzyme substrate Details Nisoldipine approved unknown enzyme substrate Details Nitrendipine approved, investigational unknown enzyme substrate Details Atorvastatin approved no enzyme substrate Details Cerivastatin approved, withdrawn unknown enzyme substrate Details Estradiol approved, investigational, vet_approved unknown enzyme substrate Details Hydrocortisone approved, vet_approved unknown enzyme substrate Details Progesterone approved, vet_approved unknown enzyme substrateinhibitor Details Testosterone approved, investigational unknown enzyme substrate Details Alfentanil approved, illicit unknown enzyme substrate Details Aripiprazole approved, investigational no enzyme substrate Details Buspirone approved, investigational unknown enzyme substrate Details Cilostazol approved, investigational unknown enzyme substrate Details Dapsone approved, investigational unknown enzyme substrate Details Dexamethasone approved, investigational, vet_approved unknown enzyme substrateinducer Details Dextromethorphan approved unknown enzyme substrate Details Docetaxel approved, investigational unknown enzyme substrate Details Domperidone approved, investigational, vet_approved unknown enzyme substrate Details Fentanyl approved, illicit, investigational, vet_approved unknown enzyme substrate Details Finasteride approved unknown enzyme substrate Details Imatinib approved no enzyme substrateinhibitor Details Haloperidol approved unknown enzyme substrate Details Irinotecan approved, investigational unknown enzyme substrate Details Levacetylmethadol approved, investigational, withdrawn unknown enzyme substrate Details Lidocaine approved, vet_approved unknown enzyme substrate Details Methadone approved unknown enzyme substrate Details Nateglinide approved, investigational unknown enzyme substrate Details Ondansetron approved, withdrawn unknown enzyme substrate Details Pimozide approved unknown enzyme substrate Details Propranolol approved, investigational unknown enzyme substrate Details Quinine approved unknown enzyme substrate Details Salmeterol approved unknown enzyme substrate Details Sildenafil approved, investigational unknown enzyme substrate Details Sirolimus approved, investigational no enzyme substrate Details Sorafenib approved, investigational unknown enzyme substrate Details Sunitinib approved, investigational unknown enzyme substrate Details Tamoxifen approved unknown enzyme substrate Details Paclitaxel approved, vet_approved unknown enzyme substrate Details Temsirolimus approved unknown enzyme substrate Details Trazodone approved, investigational unknown enzyme substrate Details Vincristine approved, investigational unknown enzyme substrate Details Zaleplon approved, illicit, investigational unknown enzyme substrate Details Itraconazole approved, investigational no enzyme inhibitor Details Chloramphenicol approved, vet_approved, withdrawn unknown enzyme inhibitor Details Ciprofloxacin approved, investigational unknown enzyme inhibitor Details Delavirdine approved unknown enzyme inhibitor Details Gestodene investigational unknown enzyme inhibitor Details Mibefradil investigational, withdrawn unknown enzyme inhibitor Details Seproxetine investigational unknown enzyme inhibitor Details Voriconazole approved unknown enzyme substrateinhibitor Details Buprenorphine approved, illicit, investigational, vet_approved unknown enzyme substrate Details Clotrimazole approved, vet_approved unknown enzyme inducer Details Imipramine approved unknown enzyme substrate Details Phenelzine approved unknown enzyme inhibitor Details Phenytoin approved, vet_approved no enzyme substrateinducer Details Rifampin approved unknown enzyme inducer Details Troglitazone approved, investigational, withdrawn unknown enzyme inhibitor Details Fluticasone propionate approved unknown enzyme substrate Details Tretinoin approved, investigational, nutraceutical unknown enzyme substrate Details Prasterone approved, investigational, nutraceutical unknown enzyme substrateinhibitor Details Prasterone sulfate investigational unknown enzyme substrate Details Phenobarbital approved, investigational no enzyme inducer Details Daclatasvir approved, investigational unknown enzyme substrate Details Idelalisib approved no enzyme substrateinhibitor Details Cobicistat approved no enzyme substrate Details Oxymetholone approved, illicit no enzyme inhibitor Details Ritonavir approved, investigational no enzyme substrateinhibitor Details Midostaurin approved, investigational unknown enzyme inducer Details Elbasvir approved unknown enzyme substrate Details Copanlisib approved, investigational no enzyme substrate Details Rucaparib approved, investigational no enzyme inhibitor Details Testosterone cypionate approved unknown enzyme substrate Details Testosterone enanthate approved unknown enzyme substrate Details Testosterone undecanoate approved, investigational unknown enzyme substrate Details Estradiol acetate approved, investigational, vet_approved unknown enzyme substrate Details Estradiol benzoate approved, investigational, vet_approved unknown enzyme substrate Details Estradiol cypionate approved, investigational, vet_approved unknown enzyme substrate Details Estradiol dienanthate approved, investigational, vet_approved unknown enzyme substrate Details Estradiol valerate approved, investigational, vet_approved unknown enzyme substrate Details Medical Cannabis experimental, investigational unknown enzyme inhibitor Details Efavirenz approved, investigational unknown enzyme inducer Details Troleandomycin approved unknown enzyme inhibitor Details Aripiprazole lauroxil approved, investigational unknown enzyme substrate Details Hydrocortisone aceponate experimental, vet_approved unknown enzyme substrate Details Hydrocortisone acetate approved, vet_approved unknown enzyme substrate Details Hydrocortisone butyrate approved, vet_approved unknown enzyme substrate Details Hydrocortisone cypionate approved, investigational, vet_approved unknown enzyme substrate Details Hydrocortisone phosphate approved, vet_approved unknown enzyme substrate Details Hydrocortisone probutate approved, vet_approved unknown enzyme substrate Details Hydrocortisone valerate approved, vet_approved unknown enzyme substrate Details Fluticasone approved, experimental unknown enzyme substrate Details Fluticasone furoate approved no enzyme substrate Details Metronidazole approved unknown enzyme substrate Details Midazolam approved, illicit unknown enzyme substrate Details Nevirapine approved unknown enzyme substrate Details Glyburide approved unknown enzyme substrate Details Triamcinolone approved, vet_approved unknown enzyme substrateinducer Details Cannabidiol approved, investigational unknown target inhibitor Details Nabiximols investigational unknown target inhibitor Details Quetiapine approved unknown enzyme Details Betamethasone approved, vet_approved unknown enzyme Details Dexamethasone acetate approved, investigational, vet_approved unknown enzyme substrateinducer Details Risdiplam approved, investigational unknown enzyme substrate Details Menadione approved, nutraceutical unknown enzyme inhibitor Details Norfloxacin approved no enzyme inhibitor Details Mobocertinib approved, investigational unknown enzyme substrate Details Cannabidiol approved, investigational no enzyme inhibitor Details Dronabinol approved, illicit no enzyme inhibitor Details Cannabinol experimental, investigational unknown enzyme inhibitor Details Clobazam approved, illicit no enzyme substrate Details Cobicistat approved yes target inhibitor Details Quizartinib approved, investigational no enzyme substrate Details Encorafenib approved, investigational no enzyme inhibitor Details Atazanavir approved, investigational no enzyme inhibitor Details Fruquintinib approved, investigational no enzyme substrate Details Mitotane approved unknown enzyme inducer Details