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Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone
smpdb.ca/view/SMP0000333SignalingIn the ovary, the FSH receptor is necessary for follicular development and is expressed on the granulosa cells.
Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone/Choriogonadotropin
smpdb.ca/view/SMP0000338SignalingLHCGRs are found in the ovary, testis, and many extragonadal tissues.In the ovary, the LHCG receptor is necessary for follicular maturation and ovulation, as well as luteal function. … In the male the LHCGR has been identified on the Leydig cells that are critical for testosterone production, and support spermatogenesis.
Metabolism and Physiological Effects of N-Acetyl-3-Methylhistidine
smpdb.ca/view/SMP0126795MetabolicN-Acetyl-3-methylhistidine, an N-acetyl-L-amino acid, belongs to the class of organic compounds known as histidine and derivatives. … N-Acetyl-3-methylhistidine is an acetylated derivative of 3-methylhistidine and a very strong basic compound (based on its pKa).
Metabolism and Physiological Effects of N-alpha-Acetyl-L-arginine
smpdb.ca/view/SMP0125530MetabolicArginnosuccinate is synthesized from citrulline and aspartic acid by the enzyme argininosuccinate synthase. That is catalyzed by argininosuccinate lyase to produce arginine and fumaric acid. … In the blood it works as a uremic toxin to cause kidney damage, cardiovascular disease and neurological deficits.
Drugs: Pyridoxal phosphate · Arginine · Aspartic acid · Ornithine · L-Glutamine · Adenosine phosphate +10 moreZiconotide NMDA and Substance P Receptor Pain Inhibition Action Pathway
smpdb.ca/view/SMP0126347Drug actionsuch as intrathecal morphine and systemic analgesics. … This causes downstream nociceptive neuronal activity and pain perception. Substance P and CGRP both also induce inflammation, further exasperating chronic pain.
Icosapent Prostaglandin G/H synthase 1 and 2 anti-inflammatory Action Pathway
smpdb.ca/view/SMP0126557Drug actionThis molecule also inhibits the arachidonic acid conversion into the thromboxane-2 and prostaglandin-2 families because it inhibits the prostaglandin G/H synthase 1 and 2 (COX-1 and COX-2). … Then icosapent shows anti-atherogenic and anti-thrombotic effects in cells. EPA serves as a substrate for Prostaglandin-endoperoxide synthase 1 and 2.
Fish oil Prostaglandin G/H synthase 1 and 2 anti-inflammatory Action Pathway
smpdb.ca/view/SMP0126563Drug actionEPA and DHA do competition with arachidonic acids for both COX-1 and COX-2 enzymes. … These are responsible for the conversion of arachidonic acid (an omega-6 fatty acid) into prostaglandins and thromboxanes, which are important mediators of inflammation and pain.
Olfactory Transduction OR5AC2
smpdb.ca/view/SMP0713863PhysiologicalThe OR5AC2 receptor has been implicated in the detection of fruity, floral, and musk-like odorants, with reported responsiveness to compounds such as heliotropin (piperonal) and ionone derivatives, which … These odorants are frequently used in fragrances and contribute to the perception of pleasant, cosmetic-like scents.
Enzymes: Calcium-activated chloride channel regulator 1Olfactory Transduction OR2AG1
smpdb.ca/view/SMP0713866PhysiologicalWhen odorant molecules enter the nasal cavity and dissolve in the mucus layer, specific odorants bind to the OR2AG1 receptor. … If this depolarization reaches threshold, it triggers an action potential that travels along the olfactory nerve to the olfactory bulb, where it is processed and transmitted to higher brain regions, such
Enzymes: Calcium-activated chloride channel regulator 1Olfactory Transduction OR2J3
smpdb.ca/view/SMP0713867PhysiologicalWhen volatile odorant molecules enter the nasal cavity and dissolve in the mucus layer, certain ligands selectively bind to the OR2J3 receptor. … The increase in intracellular cAMP opens cyclic nucleotide–gated ion channels, allowing sodium (Na⁺) and calcium (Ca²⁺) ions to enter the neuron.
Enzymes: Calcium-activated chloride channel regulator 1