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Displaying results 91 - 100 of 453 in total
  1. Target

    Vesicular inhibitory amino acid transporter

    go.drugbank.com/bio_entities/BE0002308
    TransporterHumans

    The transport is equally dependent on the chemical and electrical components of the proton gradient (By similarity). May also transport beta-alanine (By similarity). … Antiporter that exchanges vesicular protons for cytosolic 4-aminobutanoate or to a lesser extend glycine, thus allowing their secretion from nerve terminals.

    Polypeptides: Vesicular inhibitory amino acid transporterSynonyms: GABA and glycine transporter
  2. Target

    Cyclopropane mycolic acid synthase 3

    go.drugbank.com/bio_entities/BE0002521
    TargetMycobacterium tuberculosis

    It can use cis, cis 11,14-eicosadienoic acid and linoelaidic acid as substrate. … Catalyzes the conversion of a double bond to a cyclopropane ring at the proximal position of an alpha mycolic acid via the transfer of a methylene group from S-adenosyl-L-methionine.

    Polypeptides: Cyclopropane mycolic acid synthase 3Synonyms: Cyclopropane fatty acid synthase, Mycolic acid methyltransferase
  3. Target

    Fatty acid metabolism regulator protein

    go.drugbank.com/bio_entities/BE0003045
    TargetBacillus subtilis (strain 168)

    Represses transcription of genes required for fatty acid transport and beta-oxidation, including acdA, fadA, fadB, fadE, fadF, fadG, fadH, fadM, fadN, lcfA and lcfB. … Transcriptional regulator in fatty acid degradation.

    Polypeptides: Fatty acid metabolism regulator protein
  4. Target

    Fatty acid-binding protein TM_1468

    go.drugbank.com/bio_entities/BE0003182
    TargetThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)

    Binds long-chain fatty acids, such as palmitate, and may play a role in lipid transport or fatty acid metabolism.

    Polypeptides: Fatty acid-binding protein TM_1468
  5. Target

    Hepatic sodium/bile acid cotransporter

    go.drugbank.com/bio_entities/BE0003644
    TransporterTargetHumans

    Works collaboratively with the ileal transporter (NTCP2), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic … It exhibits broad substrate specificity and transports various bile acids, such as taurocholate, cholate, as well as non-bile acid organic compounds, such as estrone sulfate (PubMed:14660639, PubMed:34060352

    Polypeptides: Hepatic sodium/bile acid cotransporterSynonyms: Na(+)/bile acid cotransporter
  6. Target

    Fatty acid metabolism regulator protein

    go.drugbank.com/bio_entities/BE0004232
    TargetEscherichia coli (strain K12)

    Represses transcription of at least eight genes required for fatty acid transport and beta-oxidation including fadA, fadB, fadD, fadL and fadE (PubMed:9388199). … Activates transcription of at least three genes required for unsaturated fatty acid biosynthesis: fabA, fabB and iclR, the gene encoding the transcriptional regulator of the aceBAK operon encoding the

    Polypeptides: Fatty acid metabolism regulator protein
  7. Target

    N-acylethanolamine-hydrolyzing acid amidase

    go.drugbank.com/bio_entities/BE0009156
    TargetHumans

    Degrades bioactive fatty acid amides to their corresponding acids, with the following preference: N-palmitoylethanolamine > N-myristoylethanolamine > N-lauroylethanolamine = N-stearoylethanolamine > N-arachidonoylethanolamine … Also exhibits weak hydrolytic activity against the ceramides N-lauroylsphingosine and N-palmitoylsphingosine (PubMed:15655246)

    Polypeptides: N-acylethanolamine-hydrolyzing acid amidaseSynonyms: Acid ceramidase-like protein
  8. Target

    General transcription and DNA repair factor IIH helicase/translocase subunit XPB

    go.drugbank.com/bio_entities/BE0012820
    TargetHumans

    In transcription pre-initiation complexes induces and propagates a DNA twist to open DNA (PubMed:27193682, PubMed:33902107). … In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment.

    Polypeptides: General transcription and DNA repair factor IIH helicase/translocase subunit XPB
  9. Target

    Neutral amino acid transporter A

    go.drugbank.com/bio_entities/BE0000480
    TargetHumans

    In a tri-substrate transport cycle, exchanges neutral amino acids between the extracellular and intracellular compartments, coupled to the inward cotransport of at least one sodium ion (PubMed:24808181 … Displays sodium- and amino acid-dependent but uncoupled channel-like anion conductance with a preference SCN(-) > NO3(-) > I(-) > Cl(-) (PubMed:8910405)

    Polypeptides: Neutral amino acid transporter AFunction: amino acid transmembrane transporter activity
  10. Target

    Cationic amino acid transporter 2

    go.drugbank.com/bio_entities/BE0000562
    TargetTransporterHumans

    Functions as a permease involved in the transport of the cationic amino acids (L-arginine, L-lysine, L-ornithine and L-homoarginine); the affinity for its substrates differs between isoforms created by

    Polypeptides: Cationic amino acid transporter 2Synonyms: Low affinity cationic amino acid transporter 2