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Displaying results 91 - 100 of 2727 in total
  1. Pathway

    Phenserine Action Pathway

    smpdb.ca/view/SMP0126724
    Drug action

    Phenserine is a next-generation acetylcholinesterase, used to treat dementia. It acts as a highly selective reversible acetylcholinesterase inhibitor, which is known to increase acetylcholine levels in the synaptic cleft and enhance the ...

    Drugs: Choline · Calcium · Magnesium cation · Acetylcholine · Acetic acid · Phenserine
    Enzymes: Voltage-dependent L-type calcium channel subunit beta-4, Voltage-dependent L-type calcium channel subunit beta-1
  2. Pathway

    Doxylamine H1 Antihistamine Neurological Sleep Action Pathway

    smpdb.ca/view/SMP0126738
    Drug action

    Doxylamine is an ethanolamine class H1 antihistamine used to treat insomnia and allergy symptoms such as hay fever and hives. It is also used with pyridoxine in the treatment of nausea and vomiting in pregnancy. H1-antihistamines interfe...

    Drugs: Pyridoxal phosphate · Histidine · Doxylamine · Calcium
    Enzymes: Voltage-dependent calcium channel subunit alpha-2/delta-1, Voltage-dependent N-type calcium channel subunit alpha-1B
  3. Pathway

    Pheniramine H1 Antihistamine Neurological Sleep Action Pathway

    smpdb.ca/view/SMP0145419
    Drug action

    Pheniramine is an ethanolamine class H1 antihistamine used to treat insomnia and allergy symptoms such as hay fever and hives. It is also used with pyridoxine in the treatment of nausea and vomiting in pregnancy. H1-antihistamines interf...

    Drugs: Pyridoxal phosphate · Histidine · Calcium · Pheniramine
    Enzymes: Voltage-dependent calcium channel subunit alpha-2/delta-1, Voltage-dependent N-type calcium channel subunit alpha-1B
  4. Pathway

    Trimipramine H1 Antihistamine Neurological Sleep Action Pathway

    smpdb.ca/view/SMP0145431
    Drug action

    Trimipramine is an ethanolamine class H1 antihistamine used to treat insomnia and allergy symptoms such as hay fever and hives. It is also used with pyridoxine in the treatment of nausea and vomiting in pregnancy. H1-antihistamines inter...

    Drugs: Pyridoxal phosphate · Histidine · Trimipramine · Calcium
    Enzymes: Voltage-dependent calcium channel subunit alpha-2/delta-1, Voltage-dependent N-type calcium channel subunit alpha-1B
  5. Pathway

    Repaglinide Action Pathway

    smpdb.ca/view/SMP0000454
    Drug action

    Depolarization causes opening of voltage-gated calcium channels, allowing calcium to enter cell. High intracellular calcium subsequently stimulate vesicle exocytosis and insulin secretion.

    Drugs: ATP · Repaglinide · Potassium cation · Calcium
    Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1
  6. Pathway

    Pancreas Function - Delta Cell

    smpdb.ca/view/SMP0121128
    Physiological

    The resulting action potential from the increased membrane potential causes the voltage gate calcium channels to open, creating an influx of calcium into the cell. … Somatostatin is stored in granules in the delta cell and is released in response to an increase in blood sugar, calcium, and blood amino acids during absorption of a meal.

    Drugs: ATP · Potassium cation · Calcium
    Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1
  7. Pathway

    Tolazamide Action Pathway

    smpdb.ca/view/SMP0126144
    Drug action

    This depolarization stimulates the calcium ion influx through voltage-sensitive calcium channels thus raising intracellular concentrations of calcium ions. … The higher concentration of intracellular calcium ions induces the secretion (exocytosis) of insulin into the blood. Tolazamide is administered as an oral tablet.

    Drugs: ATP · Tolazamide · Potassium cation · Calcium
    Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1
  8. Pathway

    Glyburide Action Pathway

    smpdb.ca/view/SMP0126298
    Drug action

    Normally SUR1 closes in response to high glucose concentrations, the membrane potential of the cells becomes less negative, the cell depolarizes, voltage-gated calcium channels open, calcium ions enter … the cell, and the increased intracellular calcium concentration stimulates the release of insulin by exocytosis into the blood.

    Drugs: ATP · Glyburide · Potassium cation · Calcium
    Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1
  9. Pathway

    Gliclazide Action Pathway (New)

    smpdb.ca/view/SMP0126302
    Drug action

    The depolarization opens the voltage-dependent calcium channels in the β cell resulting in calmodulin activation, which in turn leads to the exocytosis of insulin-containing granules.

    Drugs: ATP · Gliclazide · Potassium cation · Calcium
    Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1
  10. Pathway

    Nateglinide Action Pathway (New)

    smpdb.ca/view/SMP0126392
    Drug action

    In consequence, the increased concentration of calcium results in the stimulation of the calcium-dependent exocytosis of insulin granules. … This results in the depolarization of the cell and the opening of the L-type calcium channels.

    Drugs: ATP · Nateglinide · Potassium cation · Calcium
    Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1