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Thioredoxin reductase 1, cytoplasmic
go.drugbank.com/bio_entities/BE0001979TargetEnzymeHumansHomodimeric flavoprotein involved in the regulation of cellular redox reactions, growth and differentiation. … Reduces disulfide protein thioredoxin (Trx) to its dithiol-containing form (PubMed:8577704).
Synonyms: Gene associated with retinoic and IFN-induced mortality 12 protein, Gene associated with retinoic and interferon-induced mortality 12 proteinNuclear receptor subfamily 1 group I member 2
go.drugbank.com/bio_entities/BE0000956TargetHumansUpon ligand binding, translocates to the nucleus, forms a heterodimer with the retinoid X receptor/RXR, and binds to response elements in target promoters, leading to transcriptional activation. … Nuclear receptor that acts as a transcription factor regulating genes involved in the metabolism and excretion of xenobiotics, drugs, and endogenous compounds.
Synonyms: Steroid and xenobiotic receptorRetinol dehydrogenase 12
go.drugbank.com/bio_entities/BE0000726TargetHumansMay play an important function in photoreceptor cells to detoxify 4-hydroxynonenal and potentially other toxic aldehyde products resulting from lipid peroxidation (PubMed:19686838). … Displays high activity towards 9-cis, 11-cis and all-trans-retinal. Shows very weak activity towards 13-cis-retinol (PubMed:12226107, PubMed:15865448).
Synonyms: All-trans and 9-cis retinol dehydrogenaseCytoplasmic tyrosine-protein kinase BMX
go.drugbank.com/bio_entities/BE0009416TargetHumansActivation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. … Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation.
Synonyms: Epithelial and endothelial tyrosine kinaseMyeloid zinc finger 1
go.drugbank.com/bio_entities/BE0013131TargetHumansBinds to target promoter DNA and functions as a transcription regulator. Regulates transcription from the PADI1 and CDH2 promoter.
Synonyms: Zinc finger and SCAN domain-containing protein 6NADPH oxidase organizer 1
go.drugbank.com/bio_entities/BE0002423TargetHumansTogether with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity … Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the
Synonyms: SH3 and PX domain-containing protein 5Kinesin-like protein KIF1A
go.drugbank.com/bio_entities/BE0003115TargetHumansAlso required for neuronal dense core vesicles (DCVs) transport to the dendritic spines and axons. … The interaction calcium-dependent with CALM1 increases vesicle motility and interaction with the scaffolding proteins PPFIA2 and TANC2 recruits DCVs to synaptic sites
Synonyms: Unc-104- and KIF1A-related proteinSerine/threonine-protein kinase DCLK1
go.drugbank.com/bio_entities/BE0009429TargetHumansProbable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system
Synonyms: Doublecortin-like and CAM kinase-like 1Serine/threonine-protein kinase DCLK3
go.drugbank.com/bio_entities/BE0009431TargetHumansSynonyms: Doublecortin-like and CAM kinase-like 3DNA damage-inducible transcript 4 protein
go.drugbank.com/bio_entities/BE0003445TargetHumansPlays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. … Its role in the response to hypoxia depends on the cell type; it mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes (By similarity).
Synonyms: Protein regulated in development and DNA damage response 1