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Kinesin-like protein KIF1A
go.drugbank.com/bio_entities/BE0003115TargetHumansThe interaction calcium-dependent with CALM1 increases vesicle motility and interaction with the scaffolding proteins PPFIA2 and TANC2 recruits DCVs to synaptic sites … Also required for neuronal dense core vesicles (DCVs) transport to the dendritic spines and axons.
Synonyms: Unc-104- and KIF1A-related proteinSerine/threonine-protein kinase DCLK1
go.drugbank.com/bio_entities/BE0009429TargetHumansProbable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system
Synonyms: Doublecortin-like and CAM kinase-like 1Serine/threonine-protein kinase DCLK3
go.drugbank.com/bio_entities/BE0009431TargetHumansSynonyms: Doublecortin-like and CAM kinase-like 3DNA damage-inducible transcript 4 protein
go.drugbank.com/bio_entities/BE0003445TargetHumansPlays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. … Required for mTORC1-mediated defense against viral protein synthesis and virus replication (By similarity).
Synonyms: Protein regulated in development and DNA damage response 1Caspase-4
go.drugbank.com/bio_entities/BE0009964TargetHumansLPS-binding promotes CASP4 activation and CASP4-mediated cleavage of GSDMD and IL18, followed by IL18 secretion through the GSDMD pore, pyroptosis of infected cells and their extrusion into the gut lumen … Also indirectly promotes secretion of mature cytokines (IL1A and HMGB1) downstream of GSDMD-mediated pyroptosis via activation of the NLRP3 and NLRP6 inflammasomes (PubMed:26375003, PubMed:32109412).
Synonyms: ICE and Ced-3 homolog 2Potassium-transporting ATPase ATP-binding subunit
go.drugbank.com/bio_entities/BE0003296TargetEscherichia coli (strain K12)This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm (PubMed:16354672, PubMed:30478378, PubMed:34272288).
Synonyms: Potassium-binding and translocating subunit BMyosin light chain 6B
go.drugbank.com/bio_entities/BE0004292TargetHumansRegulatory light chain of myosin. Does not bind calcium
Synonyms: Smooth muscle and nonmuscle myosin light chain alkali 6BEphrin type-A receptor 8
go.drugbank.com/bio_entities/BE0009440TargetHumansThe GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. … Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth (By similarity)
Synonyms: EPH- and ELK-related kinaseZinc transporter ZIP2
go.drugbank.com/bio_entities/BE0009889TransporterHumansThe Zn(2+) uniporter activity is independent of H(+)-driving force, but is modulated by extracellular pH and membrane potential.
Synonyms: Zrt- and Irt-like protein 23 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2
go.drugbank.com/bio_entities/BE0000059TargetEnzymeHumans3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids.
Synonyms: 3-beta-HSD adrenal and gonadal type