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Displaying results 91 - 100 of 165 in total
  1. Target

    NADPH oxidase organizer 1

    go.drugbank.com/bio_entities/BE0002423
    TargetHumans

    Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the … Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity

    Synonyms: SH3 and PX domain-containing protein 5
  2. Target

    Kinesin-like protein KIF1A

    go.drugbank.com/bio_entities/BE0003115
    TargetHumans

    The interaction calcium-dependent with CALM1 increases vesicle motility and interaction with the scaffolding proteins PPFIA2 and TANC2 recruits DCVs to synaptic sites … Also required for neuronal dense core vesicles (DCVs) transport to the dendritic spines and axons.

    Synonyms: Unc-104- and KIF1A-related protein
  3. Target

    Serine/threonine-protein kinase DCLK1

    go.drugbank.com/bio_entities/BE0009429
    TargetHumans

    Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system

    Synonyms: Doublecortin-like and CAM kinase-like 1
  4. Target

    Serine/threonine-protein kinase DCLK3

    go.drugbank.com/bio_entities/BE0009431
    TargetHumans

    Synonyms: Doublecortin-like and CAM kinase-like 3
  5. Target

    DNA damage-inducible transcript 4 protein

    go.drugbank.com/bio_entities/BE0003445
    TargetHumans

    Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. … Required for mTORC1-mediated defense against viral protein synthesis and virus replication (By similarity).

    Synonyms: Protein regulated in development and DNA damage response 1
  6. Target

    Caspase-4

    go.drugbank.com/bio_entities/BE0009964
    TargetHumans

    Activation of the non-canonical inflammasome in brain endothelial cells can lead to excessive pyroptosis, leading to blood-brain barrier breakdown (By similarity). … LPS-binding promotes CASP4 activation and CASP4-mediated cleavage of GSDMD and IL18, followed by IL18 secretion through the GSDMD pore, pyroptosis of infected cells and their extrusion into the gut lumen

    Synonyms: ICE and Ced-3 homolog 2
  7. Target

    Potassium-transporting ATPase ATP-binding subunit

    go.drugbank.com/bio_entities/BE0003296
    TargetEscherichia coli (strain K12)

    This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm (PubMed:16354672, PubMed:30478378, PubMed:34272288).

    Synonyms: Potassium-binding and translocating subunit B
  8. Target

    Myosin light chain 6B

    go.drugbank.com/bio_entities/BE0004292
    TargetHumans

    Regulatory light chain of myosin. Does not bind calcium

    Synonyms: Smooth muscle and nonmuscle myosin light chain alkali 6B
  9. Target

    Ephrin type-A receptor 8

    go.drugbank.com/bio_entities/BE0009440
    TargetHumans

    The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. … Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth (By similarity)

    Synonyms: EPH- and ELK-related kinase
  10. Target

    Zinc transporter ZIP2

    go.drugbank.com/bio_entities/BE0009889
    TransporterHumans

    The Zn(2+) uniporter activity is independent of H(+)-driving force, but is modulated by extracellular pH and membrane potential.

    Synonyms: Zrt- and Irt-like protein 2