Search
Nuclear receptor subfamily 1 group I member 2
go.drugbank.com/bio_entities/BE0000956TargetHumansNuclear receptor that acts as a transcription factor regulating genes involved in the metabolism and excretion of xenobiotics, drugs, and endogenous compounds. … Activated by a broad range of endogenous steroids (e.g. pregnenolone, progesterone) and xenobiotics, including the antibiotic rifampicin and certain plant-derived metabolites.
Synonyms: Steroid and xenobiotic receptorRetinol dehydrogenase 12
go.drugbank.com/bio_entities/BE0000726TargetHumansMay play an important function in photoreceptor cells to detoxify 4-hydroxynonenal and potentially other toxic aldehyde products resulting from lipid peroxidation (PubMed:19686838). … Displays high activity towards 9-cis, 11-cis and all-trans-retinal. Shows very weak activity towards 13-cis-retinol (PubMed:12226107, PubMed:15865448).
Synonyms: All-trans and 9-cis retinol dehydrogenaseCytoplasmic tyrosine-protein kinase BMX
go.drugbank.com/bio_entities/BE0009416TargetHumans, cell adhesion, and apoptosis. … May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells
Synonyms: Epithelial and endothelial tyrosine kinaseMyeloid zinc finger 1
go.drugbank.com/bio_entities/BE0013131TargetHumansBinds to target promoter DNA and functions as a transcription regulator. Regulates transcription from the PADI1 and CDH2 promoter.
Synonyms: Zinc finger and SCAN domain-containing protein 6NADPH oxidase organizer 1
go.drugbank.com/bio_entities/BE0002423TargetHumansConstitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the … Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity
Synonyms: SH3 and PX domain-containing protein 5Kinesin-like protein KIF1A
go.drugbank.com/bio_entities/BE0003115TargetHumansThe interaction calcium-dependent with CALM1 increases vesicle motility and interaction with the scaffolding proteins PPFIA2 and TANC2 recruits DCVs to synaptic sites … Also required for neuronal dense core vesicles (DCVs) transport to the dendritic spines and axons.
Synonyms: Unc-104- and KIF1A-related proteinSerine/threonine-protein kinase DCLK1
go.drugbank.com/bio_entities/BE0009429TargetHumansProbable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system
Synonyms: Doublecortin-like and CAM kinase-like 1Serine/threonine-protein kinase DCLK3
go.drugbank.com/bio_entities/BE0009431TargetHumansSynonyms: Doublecortin-like and CAM kinase-like 3DNA damage-inducible transcript 4 protein
go.drugbank.com/bio_entities/BE0003445TargetHumansPlays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. … Required for mTORC1-mediated defense against viral protein synthesis and virus replication (By similarity).
Synonyms: Protein regulated in development and DNA damage response 1Caspase-4
go.drugbank.com/bio_entities/BE0009964TargetHumansLPS-binding promotes CASP4 activation and CASP4-mediated cleavage of GSDMD and IL18, followed by IL18 secretion through the GSDMD pore, pyroptosis of infected cells and their extrusion into the gut lumen … Also indirectly promotes secretion of mature cytokines (IL1A and HMGB1) downstream of GSDMD-mediated pyroptosis via activation of the NLRP3 and NLRP6 inflammasomes (PubMed:26375003, PubMed:32109412).
Synonyms: ICE and Ced-3 homolog 2