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Droperidol Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126486Drug actionDroperidol is an organofluorine compound that is haloperidol in which the hydroxy group has been eliminated with the introduction of a double bond in the piperidine ring, and the 4-chlorophenyl group has been replaced by a benzimidazol-2...
Enzymes: Sodium-dependent dopamine transporterFluspirilene Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126514Drug actionFluspirilene is an antipsychotic agent used in the treatment of schizophrenia. Fluspirilene is a relatively long-acting injectable depot antipsychotic drug used for schizophrenia. Fluspirilene does not differ greatly from other depot ant...
Enzymes: Sodium-dependent dopamine transporterFlupentixol Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126515Drug actionFlupentixol is a first generation antipsychotic drug of the thioxanthene group. It exists in two geometric isomers, the trans(E) and pharmacologically active cis(Z) forms. Flupentixol decanoate is one of the active ingredients found in i...
Enzymes: Sodium-dependent dopamine transporterFlupentixol Serotonin Antagonist Action Pathway
smpdb.ca/view/SMP0126516Drug actionFlupentixol is a first generation antipsychotic drug of the thioxanthene group. It exists in two geometric isomers, the trans(E) and pharmacologically active cis(Z) forms. Flupentixol decanoate is one of the active ingredients found in i...
Enzymes: Sodium-dependent serotonin transporterPimozide Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126532Drug actionPimozide is a member of the class of benzimidazoles that is 1,3-dihydro-2H-benzimidazol-2-one in which one of the nitrogens is substituted by a piperidin-4-yl group, which in turn is substituted on the nitrogen by a 4,4-bis(p-fluoropheny...
Enzymes: Sodium-dependent dopamine transporterTrifluoperazine Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126561Drug actionTrifluoperazine is a trifluoro-methyl phenothiazine derivative. Trifluoperazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed ...
Enzymes: Sodium-dependent dopamine transporterMethotrimeprazine Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126562Drug actionMethotrimeprazine is a phenothiazine derivative, a first-generation antipsychotic, dopamine receptor antagonists (DRA) and a typical antipsychotic. Methotrimeprazine's antipsychotic effect is largely due to its antagonism of dopamine rec...
Enzymes: Sodium-dependent dopamine transporterHaloperidol Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126593Drug actionHaloperidol is a high potency first-generation (typical) antipsychotic. is indicated for the treatment of the manifestations of several psychotic disorders including schizophrenia, acute psychosis, Tourette syndrome, and other severe beh...
Enzymes: Sodium-dependent dopamine transporterPaliperidone Serotonin Antagonist Action Pathway
smpdb.ca/view/SMP0126597Drug actionPaliperidone is the primary active metabolite of risperidone. The two antipsychotics are also metabolized differently, as risperidone is metabolized in the liver mainly by the polymorphic cytochrome P450 2D6 (CYP2D6) to its active metabo...
Enzymes: Sodium-dependent serotonin transporterLumateperone SSRI Action Action Pathway
smpdb.ca/view/SMP0126693Drug actionLumateperone, also known as ITI-007, is approved for the treatment of schizophrenia in adults. It is also approved for the treatment of depressive episodes associated with bipolar disorder (i.e. bipolar depression) in adults, as monother...
Enzymes: Sodium-dependent serotonin transporter