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Vincristine
go.drugbank.com/drugs/DB00541ApprovedInvestigationalVincristine is an antitumor vinca alkaloid isolated from Vinca Rosea. … because of lack of significant bone–marrow suppression (at recommended doses) and of unique clinical toxicity (neuropathy).
Mixtures: MEODEX®, MEODEX®Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexV-type proton ATPase catalytic subunit A
go.drugbank.com/bio_entities/BE0003569TargetHumansCatalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates … May play a role in neurite development and synaptic connectivity (PubMed:29668857)
Polypeptides: V-type proton ATPase catalytic subunit ASynonyms: V-ATPase subunit ANuclear receptor subfamily 4immunitygroup A member 1
go.drugbank.com/bio_entities/BE0010494TargetHumansPlays a role in the vascular response to injury (By similarity)
Polypeptides: Nuclear receptor subfamily 4immunitygroup A member 1Inositol polyphosphate-4-phosphatase type I A
go.drugbank.com/bio_entities/BE0018619EnzymeHumansCatalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) (PubMed:15716355, PubMed:20463662). Also catalyzes inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate (By similarity). ...
Polypeptides: Inositol polyphosphate-4-phosphatase type I AInsulin detemir
go.drugbank.com/drugs/DB01307ApprovedInvestigational, which is a life-threatening medical emergency. … Insulin detemir is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes.
Categories: Cytochrome P-450 CYP1A2 Inducers, Cytochrome P-450 Enzyme InducersProducts: Levemir FlexPen 100U/ML Solution for injection in a prefilled pen, Levemir® FlexPen® 100 U/ml Solution for Injection in Pre-filled PenVascular endothelial growth factor A, long form
go.drugbank.com/bio_entities/BE0000163TargetHumansParticipates in the induction of key genes involved in the response to hypoxia and in the induction of angiogenesis such as HIF1A (PubMed:35455969). Involved in protecting cells from hypoxia-mediated cell death (By similarity)
Polypeptides: Vascular endothelial growth factor A, long form3-hydroxy-3-methylglutaryl-coenzyme A reductase
go.drugbank.com/bio_entities/BE0001856TargetPseudomonas mevaloniiP.mevalonii can use mevalonate as sole carbon source. With this enzyme mevalonate is deacetylated to HMG-CoA.
Polypeptides: 3-hydroxy-3-methylglutaryl-coenzyme A reductaseATP synthase F(0) complex subunit a
go.drugbank.com/bio_entities/BE0009014TargetHumansThese two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). … ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256).
Polypeptides: ATP synthase F(0) complex subunit aSynonyms: Proton-conducting channel, ATP synthase F(0) complex subunit aV-type proton ATPase catalytic subunit A
go.drugbank.com/bio_entities/BE0009200TargetPlasmodium falciparum (isolate 3D7)Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates
Polypeptides: V-type proton ATPase catalytic subunit ASynonyms: V-ATPase subunit APreviously treated with a BRAF inhibitor
go.drugbank.com/conditions/DBCOND0164673Drugs: LifileucelSynonyms: Previously treated with a BRAF inhibitor