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Displaying results 991 - 1000 of 3735 in total
  1. Drug

    Octisalate

    go.drugbank.com/drugs/DB11062
    Approved

    Also known as Ethylhexyl Salicylate. Octyl salicylate is an oil soluble chemical sunscreen agent that absorbs UVB radiation. It does not protect against UVA. Octyl salicylate is used to augment the UVB protection in a sunscreen. Salicyla...

    Mixtures: Kara Vita SPF 29, Kara Vita SPF 30
  2. Drug

    Simeprevir

    go.drugbank.com/drugs/DB06290
    ApprovedWithdrawn

    Simeprevir is a hepatitis C virus (HCV) NS3/4A protease inhibitor indicated in patient's with HCV genotype 1 for the treatment of chronic hepatitis C virus (HCV) infection. HCV is a single-stranded RNA virus that is categorized into nine...

    Categories: Cytochrome P-450 Substrates, P-glycoprotein inhibitors
  3. Drug

    Inotuzumab ozogamicin

    go.drugbank.com/drugs/DB05889
    ApprovedInvestigational

    Inotuzumab ozogamicin is an antibody-drug conjugate consisting of a humanized IgG4 kappa CD22-targeting monoclonal antibody covalently attached to calicheamicin derivative, N-acetyl-gamma-calicheamicin dimethylhydrazide. The antibody por...

    Categories: P-glycoprotein substrates, P-glycoprotein substrates with a Narrow Therapeutic Index
  4. Target

    G protein-coupled receptor kinase 3

    go.drugbank.com/bio_entities/BE0000018
    TargetHumans

    Such receptor phosphorylation initiates beta-arrestin-mediated receptor internalization, and signaling events leading to their desensitization (PubMed:21799898, PubMed:33859231). … Also phosphorylates ligand-bound C3a and C5a anaphylatoxin receptors (C3AR1 and C5AR1, respectively), leading to receptor desensitization (PubMed:21799898).

    Polypeptides: G protein-coupled receptor kinase 3Synonyms: Beta-adrenergic receptor kinase 2
  5. Target

    Vascular endothelial growth factor receptor 1

    go.drugbank.com/bio_entities/BE0000029
    TargetHumans

    Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival

    Polypeptides: Vascular endothelial growth factor receptor 1Synonyms: Tyrosine-protein kinase receptor FLT, Vascular permeability factor receptor
  6. Target

    Sigma non-opioid intracellular receptor 1

    go.drugbank.com/bio_entities/BE0000156
    TargetHumans

    Plays a role in protecting cells against oxidative stress-induced cell death via its interaction with RNF112 (By similarity)

    Polypeptides: Sigma non-opioid intracellular receptor 1Synonyms: Sigma1-receptor, Sigma 1-type opioid receptor
  7. Target

    Scavenger receptor class B member 1

    go.drugbank.com/bio_entities/BE0000189
    TargetTransporterHumans

    May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity (PubMed:12016218) … Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux (PubMed:26965621).

    Polypeptides: Scavenger receptor class B member 1Synonyms: Collagen type I receptor, thrombospondin receptor-like 1
  8. Target

    Platelet-derived growth factor receptor beta

    go.drugbank.com/bio_entities/BE0000205
    TargetHumans

    Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor … Tyrosine-protein kinase that acts as a cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development

    Polypeptides: Platelet-derived growth factor receptor betaSynonyms: Beta platelet-derived growth factor receptor, Platelet-derived growth factor receptor 1
  9. Target

    Neuronal acetylcholine receptor subunit alpha-10

    go.drugbank.com/bio_entities/BE0000411
    TargetHumans

    Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits. E...

    Polypeptides: Neuronal acetylcholine receptor subunit alpha-10Synonyms: Nicotinic acetylcholine receptor subunit alpha-10
  10. Target

    Putative gonadotropin-releasing hormone II receptor

    go.drugbank.com/bio_entities/BE0000472
    TargetHumans

    Putative receptor for gonadotropin releasing hormone II (GnRH II) which is most probably non-functional

    Polypeptides: Putative gonadotropin-releasing hormone II receptorSynonyms: GnRH II receptor, Type II GnRH receptor