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Cation-dependent mannose-6-phosphate receptor
go.drugbank.com/bio_entities/BE0004494TargetTransporterHumansLysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal
Polypeptides: Cation-dependent mannose-6-phosphate receptorSynonyms: CD Man-6-P receptor, 46 kDa mannose 6-phosphate receptorBone morphogenetic protein receptor type-1A
go.drugbank.com/bio_entities/BE0009272TargetHumansOn ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. … Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6.
Polypeptides: Bone morphogenetic protein receptor type-1ASynonyms: BMP type-1A receptor, Activin receptor-like kinase 3G protein-coupled receptor kinase 3
go.drugbank.com/bio_entities/BE0000018TargetHumansSuch receptor phosphorylation initiates beta-arrestin-mediated receptor internalization, and signaling events leading to their desensitization (PubMed:21799898, PubMed:33859231). … Also phosphorylates ligand-bound C3a and C5a anaphylatoxin receptors (C3AR1 and C5AR1, respectively), leading to receptor desensitization (PubMed:21799898).
Polypeptides: G protein-coupled receptor kinase 3Synonyms: Beta-adrenergic receptor kinase 2Platelet-derived growth factor receptor beta
go.drugbank.com/bio_entities/BE0000205TargetHumansReceptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor … Tyrosine-protein kinase that acts as a cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development
Polypeptides: Platelet-derived growth factor receptor betaSynonyms: Beta platelet-derived growth factor receptor, Platelet-derived growth factor receptor 1T cell receptor beta constant 1
go.drugbank.com/bio_entities/BE0003779TargetHumansConstant region of T cell receptor (TR) beta chain (PubMed:24600447).
Polypeptides: T cell receptor beta constant 1C-C chemokine receptor type 3
go.drugbank.com/bio_entities/BE0013339TargetHumansMay also act as a possible functional receptor for NARS1 (PubMed:30171954) … G protein-coupled receptor (GPCR) that plays a key role in the immune system by regulating the migration and activation of white blood cells in response to chemokines (PubMed:28994588).
Polypeptides: C-C chemokine receptor type 3Synonyms: Eosinophil eotaxin receptorC-C chemokine receptor type 8
go.drugbank.com/bio_entities/BE0013343TargetHumansG protein-coupled receptor that can bind a variety of chemokines, such as CCL1, CCL8, CCL16, CCL18 (PubMed:23999500, PubMed:35041514). Regulates monocyte and eosinophil chemotaxis.
Polypeptides: C-C chemokine receptor type 8Synonyms: Chemokine receptor-like 1, CC chemokine receptor CHEMR1C-C chemokine receptor type 9
go.drugbank.com/bio_entities/BE0002463TargetHumansReceptor for chemokine SCYA25/TECK. Subsequently transduces a signal by increasing the intracellular calcium ions level
Polypeptides: C-C chemokine receptor type 9Synonyms: G protein-coupled receptor 28Retinoic acid receptor responder protein 1
go.drugbank.com/bio_entities/BE0000653TargetHumansInhibitor of the cytoplasmic carboxypeptidase AGBL2, may regulate the alpha-tubulin tyrosination cycle
Polypeptides: Retinoic acid receptor responder protein 1Interleukin-1 receptor-associated kinase 1
go.drugbank.com/bio_entities/BE0009452TargetHumansInvolved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation.
Polypeptides: Interleukin-1 receptor-associated kinase 1