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Displaying results 1011 - 1020 of 3735 in total
  1. Target

    Receptor-type tyrosine-protein phosphatase beta

    go.drugbank.com/bio_entities/BE0003769
    TargetHumans

    Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadhe...

    Polypeptides: Receptor-type tyrosine-protein phosphatase beta
  2. Target

    T cell receptor beta constant 1

    go.drugbank.com/bio_entities/BE0003779
    TargetHumans

    Constant region of T cell receptor (TR) beta chain (PubMed:24600447).

    Polypeptides: T cell receptor beta constant 1
  3. Target

    Cation-dependent mannose-6-phosphate receptor

    go.drugbank.com/bio_entities/BE0004494
    TargetTransporterHumans

    Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal

    Polypeptides: Cation-dependent mannose-6-phosphate receptorSynonyms: CD Man-6-P receptor, 46 kDa mannose 6-phosphate receptor
  4. Target

    Receptor tyrosine-protein kinase erbB-4

    go.drugbank.com/bio_entities/BE0004772
    TargetHumans

    Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. … Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors.

    Polypeptides: Receptor tyrosine-protein kinase erbB-4Synonyms: Tyrosine kinase-type cell surface receptor HER4
  5. Target

    Membrane-associated progesterone receptor component 1

    go.drugbank.com/bio_entities/BE0004896
    TargetHumans

    Forms a ternary complex with TMEM97 receptor and low density lipid receptor/LDLR, which increases LDLR-mediated LDL lipoprotein internalization (PubMed:30443021) … Regulates heme synthesis via interactions with FECH and acts as a heme donor for at least some hemoproteins (PubMed:27599036).

    Polypeptides: Membrane-associated progesterone receptor component 1
  6. Target

    GABA(A) Receptor Benzodiazepine Binding Site

    go.drugbank.com/bio_entities/BE0008668
    TargetHumans

    GABAARs function also as histamine receptor where histamine binds at the interface of two neighboring beta subunits and potentiates GABA response (By similarity). … GABAARs function also as histamine receptor where histamine binds at the interface of two neighboring beta subunits and potentiates GABA response in a gamma-2 subunit-controlled manner (By similarity)

    Polypeptides: Gamma-aminobutyric acid receptor subunit alpha-1, Gamma-aminobutyric acid receptor subunit alpha-2Synonyms: GABA(A) receptor subunit alpha-1, GABA(A) receptor subunit alpha-2
  7. Target

    Taste receptor type 2 member 16

    go.drugbank.com/bio_entities/BE0009016
    TargetHumans

    Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5

    Polypeptides: Taste receptor type 2 member 16Function: bitter taste receptor activity
  8. Target

    Bone morphogenetic protein receptor type-1A

    go.drugbank.com/bio_entities/BE0009272
    TargetHumans

    May promote the expression of HAMP, potentially via its interaction with BMP2 (By similarity) … On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases.

    Polypeptides: Bone morphogenetic protein receptor type-1ASynonyms: BMP type-1A receptor, Activin receptor-like kinase 3
  9. Target

    Bone morphogenetic protein receptor type-2

    go.drugbank.com/bio_entities/BE0009324
    TargetHumans

    On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases.

    Polypeptides: Bone morphogenetic protein receptor type-2Synonyms: BMP type II receptor, BMP type-2 receptor
  10. Target

    Bone morphogenetic protein receptor type-1B

    go.drugbank.com/bio_entities/BE0009415
    TargetHumans

    Receptor for BMP7/OP-1 and GDF5. Positively regulates chondrocyte differentiation through GDF5 interaction … On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases.

    Polypeptides: Bone morphogenetic protein receptor type-1BSynonyms: BMP type-1B receptor